HAMAP rule MF_00491
General rule information
[?]
| Accession | MF_00491 |
| Dates | 31-OCT-2001 (Created)
3-SEP-2024 (Last updated, Version 43) |
| Name | NDH1_NuoM |
| Scope(s) |
Bacteria Cyanobacteriota Plastid |
| Template(s) | P72823 (NU4C2_SYNY3); [ Recover all ] |
| Triggered by |
HAMAP; MF_00491 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | NU4C |
| case not <OG:Chloroplast> | |
| Protein name | RecName: Full=NAD(P)H-quinone oxidoreductase chain 4; EC=7.1.1.-; AltName: Full=NAD(P)H dehydrogenase I, chain 4; AltName: Full=NDH-1, chain 4; |
| end case | |
| case <OG:Chloroplast> | |
| Protein name | RecName: Full=NAD(P)H-quinone oxidoreductase chain 4, chloroplastic; EC=7.1.1.-; AltName: Full=NAD(P)H dehydrogenase, chain 4; AltName: Full=NADH-plastoquinone oxidoreductase chain 4; |
| end case | |
| Gene name | Name=ndhD; |
Comments
[?]
| case not <OG:Chloroplast> | |
| FUNCTION | NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=a plastoquinone + NADH + (n+1) H(+)(in) = a plastoquinol + NAD(+) + n H(+)(out); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561, Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192; |
| CATALYTIC ACTIVITY | Reaction=a plastoquinone + NADPH + (n+1) H(+)(in) = a plastoquinol + NADP(+) + n H(+)(out); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561, Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192; |
| case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein. |
| else case <OC:Gloeobacter> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| else | |
| SUBCELLULAR LOCATION | Cellular thylakoid membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the complex I subunit 4 family. |
Keywords
[?]
| NAD | |
| NADP | |
| Quinone | |
| Plastoquinone | |
| case <OC:Gloeobacter> | |
| Cell membrane | |
| Cell inner membrane | |
| else | |
| Thylakoid | |
| end case | |
| Membrane | |
| Transmembrane | |
| Transmembrane helix | |
| <a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
Gene Ontology
[?]
| GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | |
| case <OG:Chloroplast> | |
| GO:0009535; Cellular component:chloroplast thylakoid membrane | |
| else case <OCellular component:Gloeobacter> | |
| GO:0005886; Cellular component:plasma membrane | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0042651; Cellular component:thylakoid membrane | |
| end case | |
Cross-references
[?]
| Pfam | PF00361; Oxidored_q1; 1; |
| PRINTS | PR01437; NUOXDRDTASE4; 1; |
| NCBIfam | TIGR01972; NDH_I_M; 1; |
| General | Transmembrane; -; 12-15; |
Features
[?]
Additional information
[?]
| Size range | 493-563 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | In dicots the initiation codon seems to be created by RNA editing (has been proven for TOBAC, ARATH, SPIOL, OENEH and snapdragon). |