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HAMAP rule MF_00491

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General rule information [?]

Accession MF_00491
Dates 31-OCT-2001 (Created)
7-DEC-2023 (Last updated, Version 42)
Name NDH1_NuoM
Scope(s) Bacteria
Template(s) P72823 (NU4C2_SYNY3); [ Recover all ]
Triggered by HAMAP; MF_00491 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NU4C
case not <OG:Chloroplast>
Protein name RecName: Full=NAD(P)H-quinone oxidoreductase chain 4;
AltName: Full=NAD(P)H dehydrogenase I, chain 4;
AltName: Full=NDH-1, chain 4;
end case
case <OG:Chloroplast>
Protein name RecName: Full=NAD(P)H-quinone oxidoreductase chain 4, chloroplastic;
AltName: Full=NAD(P)H dehydrogenase, chain 4;
AltName: Full=NADH-plastoquinone oxidoreductase chain 4;
end case
Gene name Name=ndhD;

Comments [?]

case not <OG:Chloroplast>
FUNCTIONNDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
end case
CATALYTIC ACTIVITY Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561, Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192;
CATALYTIC ACTIVITY Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561, Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192;
case <OG:Chloroplast>
SUBCELLULAR LOCATIONPlastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
else case <OC:Gloeobacter>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
SUBCELLULAR LOCATIONCellular thylakoid membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the complex I subunit 4 family.

Keywords [?]

case <OC:Gloeobacter>
Cell membrane
Cell inner membrane
end case
Transmembrane helix
<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a>

Gene Ontology [?]

GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
case <OG:Chloroplast>
GO:0009535; Cellular component:chloroplast thylakoid membrane
else case <OCellular component:Gloeobacter>
GO:0005886; Cellular component:plasma membrane
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0042651; Cellular component:thylakoid membrane
end case

Cross-references [?]

Pfam PF00361; Oxidored_q1; 1;
NCBIfam TIGR01972; NDH_I_M; 1;
General Transmembrane; -; 12-15;

Features [?]

Additional information [?]

Size range 493-563 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments In dicots the initiation codon seems to be created by RNA editing (has been proven for TOBAC, ARATH, SPIOL, OENEH and snapdragon).

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