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Annotation rule MF_00491
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General rule information [?]

Accession MF_00491
Dates 31-OCT-2001 (Created)
11-JAN-2021 (Last updated, Version 39)
Name NDH1_NuoM
Scope
Bacteria; Cyanobacteria
Plastid
Template P72823 (NU4C2_SYNY3)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NU4C
case not <OG:Chloroplast>
Protein name
RecName: Full=NAD(P)H-quinone oxidoreductase chain 4;
EC 7.1.1.-;
AltName: Full=NAD(P)H dehydrogenase I, chain 4;
AltName: Full=NDH-1, chain 4;
end case
case <OG:Chloroplast>
Protein name
RecName: Full=NAD(P)H-quinone oxidoreductase chain 4, chloroplastic;
EC 7.1.1.-;
AltName: Full=NAD(P)H dehydrogenase, chain 4;
AltName: Full=NADH-plastoquinone oxidoreductase chain 4;
end case
Gene name
ndhD

Comments [?]

case not <OG:Chloroplast>
Function NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
end case
Catalytic activity RHEA:42608: a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)
RHEA:42612: a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
else case <OC:Gloeobacter>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
else
Subcellular location Cellular thylakoid membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the complex I subunit 4 family.

Keywords [?]

NAD
NADP
Quinone
Plastoquinone
case <OC:Gloeobacter>
Cell membrane
Cell inner membrane
else
Thylakoid
end case
Membrane
Transmembrane
Transmembrane helix
Translocase

Gene Ontology [?]

GO:0016655; Molecular function: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor.
case <OG:Chloroplast>
GO:0009535; Cellular component: chloroplast thylakoid membrane.
else case <OC:Gloeobacter>
GO:0005886; Cellular component: plasma membrane.
else
GO:0042651; Cellular component: thylakoid membrane.
end case

Cross-references [?]

Pfam PF00361; Oxidored_q1; 1;
PRINTS PR01437; NUOXDRDTASE4; 1;
TIGRFAMs TIGR01972; NDH_I_M; 1;

Computed features [?]

General Transmembrane; -; 12-15; trigger=yes;

Additional information [?]

Size range 493-563 amino acids
Related rules None
Fusion None
Comments In dicots the initiation codon seems to be created by RNA editing (has been proven for TOBAC, ARATH, SPIOL, OENEH and snapdragon).


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