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HAMAP rule MF_00510

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General rule information [?]

Accession MF_00510
Dates 17-DEC-2001 (Created)
18-NOV-2019 (Last updated, Version 26)
Name Peptidase_E
Scope(s) Bacteria
Template(s) P36936 (PEPE_SALTY); [ Recover all ]
Triggered by HAMAP; MF_00510 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PEPE
Protein name RecName: Full=Peptidase E;
AltName: Full=Alpha-aspartyl dipeptidase;
AltName: Full=Asp-specific dipeptidase;
AltName: Full=Dipeptidase E;
Gene name Name=pepE;

Comments [?]

FUNCTIONHydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
CATALYTIC ACTIVITY Reaction=Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|- Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.; EC=;
SIMILARITYBelongs to the peptidase S51 family.

Keywords [?]

Gene Ontology [?]

GO:0016805; Molecular function:dipeptidase activity
GO:0006508; Biological process:proteolysis
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF03575; Peptidase_S51; 1;

Features [?]

From: PEPE_SALTY (P36936)
Key From To Description Tag Condition FTGroup
ACT_SITE 120 120 /note="Charge relay system" S
ACT_SITE 135 135 /note="Charge relay system" D
ACT_SITE 157 157 /note="Charge relay system" H

Additional information [?]

Size range 218-243 amino acids
Related rules None
Fusion Nter: None Cter: None

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