HAMAP rule MF_00510
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00510 |
| Accession | MF_00510 |
| Dates | 28-FEB-2005 (Created)
18-NOV-2019 (Last updated, Version 18) |
| Name | Peptidase_E |
| Scope(s) |
Bacteria |
| Template(s) | P36936; [ Recover all ] |
| Triggered by |
HAMAP; MF_00510 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PEPE |
| Protein name | RecName: Full=Peptidase E; EC=3.4.13.21; AltName: Full=Alpha-aspartyl dipeptidase; AltName: Full=Asp-specific dipeptidase; AltName: Full=Dipeptidase E; |
| Gene name | Name=pepE; |
Comments
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| FUNCTION | Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids. |
| CATALYTIC ACTIVITY | Reaction=Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|- Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.; EC=3.4.13.21; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the peptidase S51 family. |
Keywords
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Gene Ontology
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| GO:0016805; Molecular function:dipeptidase activity |
| GO:0006508; Biological process:proteolysis |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF03575; Peptidase_S51; 1; |
Features
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| From: PEPE_SALTY (P36936) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 120 | 120 | /note="Charge relay system" | S | ||||||||
| ACT_SITE | 135 | 135 | /note="Charge relay system" | D | ||||||||
| ACT_SITE | 157 | 157 | /note="Charge relay system" | H | ||||||||
Additional information
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| Size range | 218-243 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |