HAMAP rule MF_00510

General rule information [?]

Accession	MF_00510
Dates	17-DEC-2001 (Created) 18-NOV-2019 (Last updated, Version 26)

Name	Peptidase_E

Scope

Bacteria

Template

P36936 (PEPE_SALTY)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PEPE

Protein name

RecName:		Full=Peptidase E;
		EC 3.4.13.21;
AltName:		Full=Alpha-aspartyl dipeptidase;
AltName:		Full=Asp-specific dipeptidase;
AltName:		Full=Dipeptidase E;

Gene name

pepE

Comments [?]

Function	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
Catalytic activity	Reaction=Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-\|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.; EC=3.4.13.21;
Subcellular location	Cytoplasm.
Similarity	Belongs to the peptidase S51 family.

Keywords [?]

Gene Ontology [?]

GO:0016805; Molecular function: dipeptidase activity.
GO:0006508; Biological process: proteolysis.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF03575; Peptidase_S51; 1;

Features [?]

From: PEPE_SALTY (P36936)

Key From To Description Tag Condition FTGroup

ACT_SITE 120 120 Charge relay system S

ACT_SITE 135 135 Charge relay system D

ACT_SITE 157 157 Charge relay system H

Additional information [?]