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HAMAP rule MF_00510

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General rule information [?]

Accession MF_00510
Dates 17-DEC-2001 (Created)
18-NOV-2019 (Last updated, Version 26)
Name Peptidase_E
Template P36936 (PEPE_SALTY)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Peptidase E;
AltName: Full=Alpha-aspartyl dipeptidase;
AltName: Full=Asp-specific dipeptidase;
AltName: Full=Dipeptidase E;
Gene name

Comments [?]

Function Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
Catalytic activity Reaction=Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.; EC=;
Subcellular location Cytoplasm.
Similarity Belongs to the peptidase S51 family.

Keywords [?]

Gene Ontology [?]

GO:0016805; Molecular function: dipeptidase activity.
GO:0006508; Biological process: proteolysis.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF03575; Peptidase_S51; 1;

Features [?]

From: PEPE_SALTY (P36936)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     120     120       Charge relay system     S  
ACT_SITE     135     135       Charge relay system     D  
ACT_SITE     157     157       Charge relay system     H  

Additional information [?]

Size range 218-243 amino acids
Related rules None
Fusion None