HAMAP rule MF_00519
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00519 |
| Accession | MF_00519 |
| Dates | 28-FEB-2005 (Created)
13-JUN-2025 (Last updated, Version 27) |
| Name | Arabinose_Isome |
| Scope(s) |
Bacteria |
| Template(s) | P08202; Q9S467; [ Recover all ] |
| Triggered by |
HAMAP; MF_00519 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ARAA |
| Protein name | RecName: Full=L-arabinose isomerase; EC=5.3.1.4; |
| Gene name | Name=araA; |
Comments
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| FUNCTION | Catalyzes the conversion of L-arabinose to L-ribulose. |
| CATALYTIC ACTIVITY | Reaction=beta-L-arabinopyranose = L-ribulose; Xref=Rhea:RHEA:14821, ChEBI:CHEBI:16880, ChEBI:CHEBI:40886; EC=5.3.1.4; |
| case <FTGroup:1> | |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 1 Mn(2+) ion per subunit.; |
| end case | |
| PATHWAY | Carbohydrate degradation; L-arabinose degradation via L- ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. |
| case <OC:Enterobacterales> | |
| SUBUNIT | Homohexamer. |
| end case | |
| SIMILARITY | Belongs to the arabinose isomerase family. |
Keywords
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| Arabinose catabolism | |
| Carbohydrate metabolism | |
| Isomerase | |
| case <FTGroup:1> | |
| Manganese | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0008733; Molecular function:L-arabinose isomerase activity | |
| case <FTGroup:1> | |
| GO:0030145; Molecular function:manganese ion binding | |
| end case | |
| GO:0019569; Biological process:L-arabinose catabolic process to D-xylulose 5-phosphate | |
Cross-references
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| Pfam | PF02610; Arabinose_Isome; 1; |
Features
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| From: ARAA_ECOLI (P08202) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 306 | 306 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
E | 1 | |||||||
| BINDING | 333 | 333 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
E | 1 | |||||||
| BINDING | 350 | 350 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
H | 1 | |||||||
| BINDING | 450 | 450 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
H | 1 | |||||||
Additional information
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| Size range | 474-511 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |