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HAMAP rule MF_00526

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General rule information [?]

Accession MF_00526
Dates 16-JAN-2002 (Created)
19-NOV-2022 (Last updated, Version 32)
Name Me_Asp_mutase_S
Templates P80078 (GMSS_CLOCO); Q05488 (GMSS_CLOTT): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Glutamate mutase sigma subunit;
AltName: Full=Glutamate mutase S chain;
AltName: Full=Glutamate mutase small subunit;
AltName: Full=Methylaspartate mutase;
Gene name

Comments [?]

Function Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
Catalytic activity RHEA:12857: (2S,3S)-3-methyl-L-aspartate = L-glutamate
Cofactor adenosylcob(III)alamin
Pathway Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.
Subunit Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
Similarity Belongs to the methylaspartate mutase GlmS subunit family.

Keywords [?]

Gene Ontology [?]

GO:0050097; Molecular function: methylaspartate mutase activity.
GO:0019670; Biological process: anaerobic glutamate catabolic process.

Cross-references [?]

Pfam PF02310; B12-binding; 1;
PROSITE PS51332; B12_BINDING; 1; trigger=PRU00666;
TIGRFAMs TIGR01501; MthylAspMutase; 1;

Features [?]

From: GMSS_CLOCO (P80078)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     13     17       /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408     [SA]-D-[CVA]-H-[ATV]  
BINDING (Optional)     61     63       /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408     S-S-[LI]  
BINDING (Optional)     93     97       /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408     N-[LI]-[VGA]-[VI]-[G]  
BINDING     16     16       /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" /ligand_part="Co" /ligand_part_id="ChEBI:CHEBI:27638" /note="axial binding residue     H  

Additional information [?]

Size range 130-175 amino acids
Related rules None
Fusion None