HAMAP

Accession	MF_00526
Dates	16-JAN-2002 (Created) 10-OCT-2014 (Last updated, Version 26)

Name	Me_Asp_mutase_S

Scope

Bacteria Archaea

Templates

P80078 (GMSS_CLOCO); Q05488 (GMSS_CLOTT): [Recover all]

Triggered by

HAMAP; MF_00526 (Get profile general information and statistics)

Identifier

GMSS

Protein name

RecName: Full=Glutamate mutase sigma subunit; EC=5.4.99.1; AltName: Full=Glutamate mutase S chain; AltName: Full=Glutamate mutase small subunit; AltName: Full=Methylaspartate mutase;

Gene name

glmS

Function	Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
Catalytic activity	L-threo-3-methylaspartate = L-glutamate.
Cofactor	adenosylcob(III)alamin
Pathway	Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.
Subunit	Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
Similarity	Belongs to the methylaspartate mutase GlmS subunit family.

Cobalamin
Cobalt
Isomerase
Metal-binding

GO:0050097; Molecular function: methylaspartate mutase activity.
GO:0019670; Biological process: anaerobic glutamate catabolic process.

Pfam	PF02310; B12-binding; 1;
PROSITE	PS51332; B12_BINDING; 1; trigger=PRU00666;
TIGRFAMs	TIGR01501; MthylAspMutase; 1;

From: GMSS_CLOCO (P80078)

Key

From

To

Description

Tag

Condition

FTGroup

REGION (Optional)

13

17

Adenosylcobalamin binding

[SA]-D-[CVA]-H-[ATV]

REGION (Optional)

61

63

Adenosylcobalamin binding

S-S-[LI]

REGION (Optional)

93

97

Adenosylcobalamin binding

N-[LI]-[VGA]-[VI]-[G]

METAL

16

16

Cobalt (cobalamin axial ligand)

H

Size range	130-175 amino acids
Related rules	None
Fusion	None

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