HAMAP rule MF_00526
General rule information
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Accession | MF_00526 |
Dates | 16-JAN-2002 (Created) 19-NOV-2022 (Last updated, Version 32) |
Name | Me_Asp_mutase_S |
Scope | Bacteria
Archaea |
Templates | P80078 (GMSS_CLOCO); Q05488 (GMSS_CLOTT): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). |
Catalytic activity | RHEA:12857: (2S,3S)-3-methyl-L-aspartate = L-glutamate
EC 5.4.99.1 |
Cofactor | adenosylcob(III)alamin |
Pathway | Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4. |
Subunit | Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer. |
Similarity | Belongs to the methylaspartate mutase GlmS subunit family. |
Keywords
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Gene Ontology
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GO:0050097; Molecular function: methylaspartate mutase activity.
GO:0019670; Biological process: anaerobic glutamate catabolic process.
GO:0019670; Biological process: anaerobic glutamate catabolic process.
Cross-references
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Pfam | PF02310; B12-binding; 1; |
PROSITE | PS51332; B12_BINDING; 1; trigger=PRU00666; |
TIGRFAMs | TIGR01501; MthylAspMutase; 1; |
Features
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From: GMSS_CLOCO (P80078) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 13 | 17 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408 | [SA]-D-[CVA]-H-[ATV] | ||||||||
BINDING (Optional) | 61 | 63 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408 | S-S-[LI] | ||||||||
BINDING (Optional) | 93 | 97 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408 | N-[LI]-[VGA]-[VI]-[G] | ||||||||
BINDING | 16 | 16 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" /ligand_part="Co" /ligand_part_id="ChEBI:CHEBI:27638" /note="axial binding residue | H |
Additional information
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Size range | 130-175 amino acids |
Related rules | None |
Fusion | None |