HAMAP rule MF_00526
General rule information
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Accession | MF_00526 |
Dates | 16-JAN-2002 (Created)
7-MAY-2024 (Last updated, Version 34) |
Name | Me_Asp_mutase_S |
Scope(s) |
Bacteria Archaea |
Template(s) | P80078 (GMSS_CLOCO); Q05488 (GMSS_CLOTT); [ Recover all ] |
Triggered by |
HAMAP; MF_00526 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GMSS |
Protein name | RecName: Full=Glutamate mutase sigma subunit; EC=5.4.99.1; AltName: Full=Glutamate mutase S chain; AltName: Full=Glutamate mutase small subunit; AltName: Full=Methylaspartate mutase; |
Gene name | Name=glmS; |
Comments
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FUNCTION | Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). |
CATALYTIC ACTIVITY | Reaction=(2S,3S)-3-methyl-L-aspartate = L-glutamate; Xref=Rhea:RHEA:12857, ChEBI:CHEBI:29985, ChEBI:CHEBI:58724; EC=5.4.99.1; |
COFACTOR | Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408; |
PATHWAY | Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4. |
SUBUNIT | Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer. |
SIMILARITY | Belongs to the methylaspartate mutase GlmS subunit family. |
Keywords
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Gene Ontology
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GO:0050097; Molecular function:methylaspartate mutase activity |
GO:0019553; Biological process:glutamate catabolic process via L-citramalate |
Cross-references
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Pfam | PF02310; B12-binding; 1; |
PROSITE | PS51332; B12_BINDING; 1; |
NCBIfam | TIGR01501; MthylAspMutase; 1; |
Features
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From: GMSS_CLOCO (P80078) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 13 | 17 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
[SA]-D-[CVA]-H-[ATV] | ||||||||
BINDING | 61 | 63 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
S-S-[LI] | ||||||||
BINDING | 93 | 97 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
N-[LI]-[VGA]-[VI]-[G] | ||||||||
BINDING | 16 | 16 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" /ligand_part="Co" /ligand_part_id="ChEBI:CHEBI:27638" /note="axial binding residue" |
H |
Additional information
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Size range | 130-175 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |