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HAMAP rule MF_00526

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General rule information [?]

Accession MF_00526
Dates 16-JAN-2002 (Created)
1-JUN-2023 (Last updated, Version 33)
Name Me_Asp_mutase_S
Scope(s) Bacteria
Template(s) P80078 (GMSS_CLOCO); Q05488 (GMSS_CLOTT); [ Recover all ]
Triggered by HAMAP; MF_00526 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GMSS
Protein name RecName: Full=Glutamate mutase sigma subunit;
AltName: Full=Glutamate mutase S chain;
AltName: Full=Glutamate mutase small subunit;
AltName: Full=Methylaspartate mutase;
Gene name Name=glmS;

Comments [?]

FUNCTIONCatalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
CATALYTIC ACTIVITY Reaction=(2S,3S)-3-methyl-L-aspartate = L-glutamate; Xref=Rhea:RHEA:12857, ChEBI:CHEBI:29985, ChEBI:CHEBI:58724; EC=;
COFACTOR Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
PATHWAYAmino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.
SUBUNITHeterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
SIMILARITYBelongs to the methylaspartate mutase GlmS subunit family.

Keywords [?]

Gene Ontology [?]

GO:0050097; Molecular function:methylaspartate mutase activity
GO:0019670; Biological process:anaerobic glutamate catabolic process

Cross-references [?]

Pfam PF02310; B12-binding; 1;
NCBIfam TIGR01501; MthylAspMutase; 1;

Features [?]

From: GMSS_CLOCO (P80078)
Key From To Description Tag Condition FTGroup
BINDING 13 17 /ligand="adenosylcob(III)alamin"
BINDING 61 63 /ligand="adenosylcob(III)alamin"
BINDING 93 97 /ligand="adenosylcob(III)alamin"
BINDING 16 16 /ligand="adenosylcob(III)alamin"
/note="axial binding residue"

Additional information [?]

Size range 130-175 amino acids
Related rules None
Fusion Nter: None Cter: None

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