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Annotation rule MF_00526
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General rule information [?]

Accession MF_00526
Dates 16-JAN-2002 (Created)
18-NOV-2019 (Last updated, Version 28)
Name Me_Asp_mutase_S
Scope
Bacteria
Archaea
Templates P80078 (GMSS_CLOCO); Q05488 (GMSS_CLOTT): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GMSS
Protein name
RecName: Full=Glutamate mutase sigma subunit;
EC 5.4.99.1;
AltName: Full=Glutamate mutase S chain;
AltName: Full=Glutamate mutase small subunit;
AltName: Full=Methylaspartate mutase;
Gene name
glmS

Comments [?]

Function Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
Catalytic activity RHEA:12857: (2S,3S)-3-methyl-L-aspartate = L-glutamate
EC 5.4.99.1
Cofactor adenosylcob(III)alamin
Pathway Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.
Subunit Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
Similarity Belongs to the methylaspartate mutase GlmS subunit family.

Keywords [?]

Cobalamin
Cobalt
Isomerase
Metal-binding

Gene Ontology [?]

GO:0050097; Molecular function: methylaspartate mutase activity.
GO:0019670; Biological process: anaerobic glutamate catabolic process.

Cross-references [?]

Pfam PF02310; B12-binding; 1;
PROSITE PS51332; B12_BINDING; 1; trigger=PRU00666;
TIGRFAMs TIGR01501; MthylAspMutase; 1;

Features [?]

From: GMSS_CLOCO (P80078)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     13     17       Adenosylcobalamin binding     [SA]-D-[CVA]-H-[ATV]  
REGION (Optional)     61     63       Adenosylcobalamin binding     S-S-[LI]  
REGION (Optional)     93     97       Adenosylcobalamin binding     N-[LI]-[VGA]-[VI]-[G]  
METAL     16     16       Cobalt (cobalamin axial ligand)     H  

Additional information [?]

Size range 130-175 amino acids
Related rules None
Fusion None


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