HAMAP rule MF_00526

General rule information [?]

Accession	MF_00526
Dates	16-JAN-2002 (Created) 19-NOV-2022 (Last updated, Version 32)

Name	Me_Asp_mutase_S

Scope

Bacteria

Archaea

Templates

P80078 (GMSS_CLOCO); Q05488 (GMSS_CLOTT): [Recover all]

Triggered by

HAMAP; MF_00526 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GMSS

Protein name

RecName:		Full=Glutamate mutase sigma subunit;
		EC 5.4.99.1;
AltName:		Full=Glutamate mutase S chain;
AltName:		Full=Glutamate mutase small subunit;
AltName:		Full=Methylaspartate mutase;

Gene name

glmS

Comments [?]

Function	Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
Catalytic activity	RHEA:12857: (2S,3S)-3-methyl-L-aspartate = L-glutamate EC 5.4.99.1
Cofactor	adenosylcob(III)alamin
Pathway	Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.
Subunit	Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
Similarity	Belongs to the methylaspartate mutase GlmS subunit family.

Keywords [?]

Cobalamin
Cobalt
Isomerase
Metal-binding

Gene Ontology [?]

GO:0050097; Molecular function: methylaspartate mutase activity.
GO:0019670; Biological process: anaerobic glutamate catabolic process.

Cross-references [?]

Pfam	PF02310; B12-binding; 1;
PROSITE	PS51332; B12_BINDING; 1; trigger=PRU00666;
TIGRFAMs	TIGR01501; MthylAspMutase; 1;

Features [?]

From: GMSS_CLOCO (P80078)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 13 17 /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408 [SA]-D-[CVA]-H-[ATV]

BINDING (Optional) 61 63 /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408 S-S-[LI]

BINDING (Optional) 93 97 /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408 N-[LI]-[VGA]-[VI]-[G]

BINDING 16 16 /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" /ligand_part="Co" /ligand_part_id="ChEBI:CHEBI:27638" /note="axial binding residue H

Additional information [?]

Size range	130-175 amino acids
Related rules	None
Fusion	None

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