HAMAP rule MF_00526
General rule information
[?]
| Accession | MF_00526 |
| Dates | 16-JAN-2002 (Created)
1-JUN-2023 (Last updated, Version 33) |
| Name | Me_Asp_mutase_S |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P80078 (GMSS_CLOCO); Q05488 (GMSS_CLOTT); [ Recover all ] |
| Triggered by |
HAMAP; MF_00526 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | GMSS |
| Protein name | RecName: Full=Glutamate mutase sigma subunit; EC=5.4.99.1; AltName: Full=Glutamate mutase S chain; AltName: Full=Glutamate mutase small subunit; AltName: Full=Methylaspartate mutase; |
| Gene name | Name=glmS; |
Comments
[?]
| FUNCTION | Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). |
| CATALYTIC ACTIVITY | Reaction=(2S,3S)-3-methyl-L-aspartate = L-glutamate; Xref=Rhea:RHEA:12857, ChEBI:CHEBI:29985, ChEBI:CHEBI:58724; EC=5.4.99.1; |
| COFACTOR | Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408; |
| PATHWAY | Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4. |
| SUBUNIT | Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer. |
| SIMILARITY | Belongs to the methylaspartate mutase GlmS subunit family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0050097; Molecular function:methylaspartate mutase activity |
| GO:0019670; Biological process:anaerobic glutamate catabolic process |
Cross-references
[?]
| Pfam | PF02310; B12-binding; 1; |
| PROSITE | PS51332; B12_BINDING; 1; |
| NCBIfam | TIGR01501; MthylAspMutase; 1; |
Features
[?]
| From: GMSS_CLOCO (P80078) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 13 | 17 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
[SA]-D-[CVA]-H-[ATV] | ||||||||
| BINDING | 61 | 63 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
S-S-[LI] | ||||||||
| BINDING | 93 | 97 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
N-[LI]-[VGA]-[VI]-[G] | ||||||||
| BINDING | 16 | 16 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" /ligand_part="Co" /ligand_part_id="ChEBI:CHEBI:27638" /note="axial binding residue" |
H | ||||||||
Additional information
[?]
| Size range | 130-175 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |