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| Annotation rule MF_00544 |
General rule information
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| Accession | MF_00544 |
| Dates | 8-MAR-2002 (Created) 18-NOV-2019 (Last updated, Version 30) |
| Name | Tryptophanase |
| Scope | Bacteria
Archaea |
| Templates | P0A853 (TNAA_ECOLI); P28796 (TNAA_PROVU): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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case <OC:Bacteria>
| Protein name |
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end case
case <OC:Archaea>
| Protein name |
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end case
| Gene name |
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Comments
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| Catalytic activity | RHEA:19553: H2O + L-tryptophan = indole + NH4(+) + pyruvate
EC 4.1.99.1 |
| Cofactor | pyridoxal 5'-phosphate |
| Pathway | Amino-acid degradation; L-tryptophan degradation via pyruvate pathway; indole and pyruvate from L-tryptophan: step 1/1. |
case <OC:Bacteria>
| Subunit | Homotetramer. |
end case
| Similarity | Belongs to the beta-eliminating lyase family. |
Keywords
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case <FT:2> or <FT:3> or <FT:4> or <FT:5>
end case
Gene Ontology
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GO:0009034; Molecular function: tryptophanase activity.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0006569; Biological process: tryptophan catabolic process.
Cross-references
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| Pfam | PF01212; Beta_elim_lyase; 1; |
| TIGRFAMs | TIGR02617; tnaA_trp_ase; 1; |
| PROSITE | PS00853; BETA_ELIM_LYASE; 1; |
Features
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| From: TNAA_ECOLI (P0A853) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 270 | 270 | N6-(pyridoxal phosphate)lysine | K | ||||||||
case <OC:Escherichia> or <OC:Shigella>
| MOD_RES | 5 | 5 | N6-acetyllysine | K | ||||||||
| MOD_RES | 115 | 115 | N6-acetyllysine | K | ||||||||
| MOD_RES | 156 | 156 | N6-acetyllysine | K | ||||||||
| MOD_RES | 450 | 450 | N6-acetyllysine | K |
end case
Additional information
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| Size range | 448-473 amino acids |
| Related rules | MF_00543 (TPL supersedes the current rule) |
| Fusion | None |