HAMAP logo

HAMAP rule MF_00544

Send feedback

General rule information [?]

Accession MF_00544
Dates 8-MAR-2002 (Created)
1-JUN-2023 (Last updated, Version 31)
Name Tryptophanase
Scope(s) Bacteria
Template(s) P0A853 (TNAA_ECOLI); P28796 (TNAA_PROVU); [ Recover all ]
Triggered by HAMAP; MF_00544 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TNAA
case <OC:Bacteria>
Protein name RecName: Full=Tryptophanase;
AltName: Full=L-tryptophan indole-lyase;
end case
case <OC:Archaea>
Protein name RecName: Full=Probable tryptophanase;
AltName: Full=L-tryptophan indole-lyase;
end case
Gene name Name=tnaA;

Comments [?]

CATALYTIC ACTIVITY Reaction=H2O + L-tryptophan = indole + NH4(+) + pyruvate; Xref=Rhea:RHEA:19553, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:16881, ChEBI:CHEBI:28938, ChEBI:CHEBI:57912; EC=;
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
PATHWAYAmino-acid degradation; L-tryptophan degradation via pyruvate pathway; indole and pyruvate from L-tryptophan: step 1/1.
case <OC:Bacteria>
end case
SIMILARITYBelongs to the beta-eliminating lyase family.

Keywords [?]

case <FT:2> or <FT:3> or <FT:4> or <FT:5>
end case
Pyridoxal phosphate
Tryptophan catabolism

Gene Ontology [?]

GO:0009034; Molecular function:tryptophanase activity
GO:0006569; Biological process:tryptophan catabolic process

Cross-references [?]

Pfam PF01212; Beta_elim_lyase; 1;
NCBIfam TIGR02617; tnaA_trp_ase; 1;

Features [?]

From: TNAA_ECOLI (P0A853)
Key From To Description Tag Condition FTGroup
MOD_RES 270 270 /note="N6-(pyridoxal phosphate)lysine" K
case <OC:Escherichia> or <OC:Shigella>
MOD_RES 5 5 /note="N6-acetyllysine" K
MOD_RES 115 115 /note="N6-acetyllysine" K
MOD_RES 156 156 /note="N6-acetyllysine" K
MOD_RES 450 450 /note="N6-acetyllysine" K
end case

Additional information [?]

Size range 448-473 amino acids
Related rules MF_00543
Fusion Nter: None Cter: None

View rule in raw text format (no links)