HAMAP rule MF_00544
General rule information
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| Accession | MF_00544 |
| Dates | 8-MAR-2002 (Created)
1-JUN-2023 (Last updated, Version 31) |
| Name | Tryptophanase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A853 (TNAA_ECOLI); P28796 (TNAA_PROVU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00544 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TNAA |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=Tryptophanase; EC=4.1.99.1; AltName: Full=L-tryptophan indole-lyase; Short=TNase; |
| end case | |
| case <OC:Archaea> | |
| Protein name | RecName: Full=Probable tryptophanase; EC=4.1.99.1; AltName: Full=L-tryptophan indole-lyase; Short=TNase; |
| end case | |
| Gene name | Name=tnaA; |
Comments
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| CATALYTIC ACTIVITY | Reaction=H2O + L-tryptophan = indole + NH4(+) + pyruvate; Xref=Rhea:RHEA:19553, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:16881, ChEBI:CHEBI:28938, ChEBI:CHEBI:57912; EC=4.1.99.1; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| PATHWAY | Amino-acid degradation; L-tryptophan degradation via pyruvate pathway; indole and pyruvate from L-tryptophan: step 1/1. |
| case <OC:Bacteria> | |
| SUBUNIT | Homotetramer. |
| end case | |
| SIMILARITY | Belongs to the beta-eliminating lyase family. |
Keywords
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| case <FT:2> or <FT:3> or <FT:4> or <FT:5> | |
| Acetylation | |
| end case | |
| Lyase | |
| Pyridoxal phosphate | |
| Tryptophan catabolism | |
Gene Ontology
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| GO:0009034; Molecular function:tryptophanase activity |
| GO:0006569; Biological process:tryptophan catabolic process |
Cross-references
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| Pfam | PF01212; Beta_elim_lyase; 1; |
| NCBIfam | TIGR02617; tnaA_trp_ase; 1; |
| PROSITE | PS00853; BETA_ELIM_LYASE; 1; |
Features
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| From: TNAA_ECOLI (P0A853) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 270 | 270 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
| case <OC:Escherichia> or <OC:Shigella> | ||||||||||||
| MOD_RES | 5 | 5 | /note="N6-acetyllysine" | K | ||||||||
| MOD_RES | 115 | 115 | /note="N6-acetyllysine" | K | ||||||||
| MOD_RES | 156 | 156 | /note="N6-acetyllysine" | K | ||||||||
| MOD_RES | 450 | 450 | /note="N6-acetyllysine" | K | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 448-473 amino acids |
| Related rules |
MF_00543 |
| Fusion | Nter: None Cter: None |