Home  |  Contact
Annotation rule MF_00544
Send feedback

General rule information [?]

Accession MF_00544
Dates 8-MAR-2002 (Created)
18-NOV-2019 (Last updated, Version 30)
Name Tryptophanase
Scope
Bacteria
Archaea
Templates P0A853 (TNAA_ECOLI); P28796 (TNAA_PROVU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TNAA
case <OC:Bacteria>
Protein name
RecName: Full=Tryptophanase;
EC 4.1.99.1;
AltName: Full=L-tryptophan indole-lyase;
Short=TNase;
end case
case <OC:Archaea>
Protein name
RecName: Full=Probable tryptophanase;
EC 4.1.99.1;
AltName: Full=L-tryptophan indole-lyase;
Short=TNase;
end case
Gene name
tnaA

Comments [?]

Catalytic activity RHEA:19553: H2O + L-tryptophan = indole + NH4(+) + pyruvate
EC 4.1.99.1
Cofactor pyridoxal 5'-phosphate
Pathway Amino-acid degradation; L-tryptophan degradation via pyruvate pathway; indole and pyruvate from L-tryptophan: step 1/1.
case <OC:Bacteria>
Subunit Homotetramer.
end case
Similarity Belongs to the beta-eliminating lyase family.

Keywords [?]

case <FT:2> or <FT:3> or <FT:4> or <FT:5>
end case

Gene Ontology [?]

GO:0009034; Molecular function: tryptophanase activity.
GO:0006569; Biological process: tryptophan catabolic process.

Cross-references [?]

Pfam PF01212; Beta_elim_lyase; 1;
TIGRFAMs TIGR02617; tnaA_trp_ase; 1;
PROSITE PS00853; BETA_ELIM_LYASE; 1;

Features [?]

From: TNAA_ECOLI (P0A853)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     270     270       N6-(pyridoxal phosphate)lysine     K  
case <OC:Escherichia> or <OC:Shigella>
MOD_RES     5     5       N6-acetyllysine     K  
MOD_RES     115     115       N6-acetyllysine     K  
MOD_RES     156     156       N6-acetyllysine     K  
MOD_RES     450     450       N6-acetyllysine     K  
end case

Additional information [?]

Size range 448-473 amino acids
Related rules MF_00543 (TPL supersedes the current rule)
Fusion None