HAMAP rule MF_00548
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00548 |
| Accession | MF_00548 |
| Dates | 28-FEB-2005 (Created)
09-MAR-2023 (Last updated, Version 24) |
| Name | ZupT |
| Scope(s) |
Bacteria |
| Template(s) | P0A8H3; P67470; [ Recover all ] |
| Triggered by |
HAMAP; MF_00548 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ZUPT |
| Protein name | RecName: Full=Zinc transporter ZupT; |
| Gene name | Name=zupT; |
Comments
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| FUNCTION | Mediates zinc uptake. May also transport other divalent cations. |
| CATALYTIC ACTIVITY | Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351, ChEBI:CHEBI:29105; |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily. |
Keywords
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| Cell membrane | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Ion transport | |
| Membrane | |
| Transmembrane | |
| Transmembrane helix | |
| Transport | |
| Zinc | |
| Zinc transport | |
Gene Ontology
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| GO:0005385; Molecular function:zinc ion transmembrane transporter activity |
| GO:0071577; Biological process:zinc ion transmembrane transport |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF02535; Zip; 1; |
| General | Transmembrane; -; 7-8; |
Features
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| From: ZUPT_ECOLI (P0A8H3) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 120 | 120 | /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" /note="M2 metal binding site" |
N | ||||||||
| BINDING | 123 | 123 | /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" /note="M2 metal binding site" |
E | ||||||||
| BINDING | 123 | 123 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /note="M1 metal binding site" |
E | ||||||||
| BINDING | 148 | 148 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /note="M1 metal binding site" |
H | ||||||||
| BINDING | 149 | 149 | /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" /note="M2 metal binding site" |
N | ||||||||
| BINDING | 152 | 152 | /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" /note="M2 metal binding site" |
E | ||||||||
| BINDING | 152 | 152 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /note="M1 metal binding site" |
E | ||||||||
| BINDING | 181 | 181 | /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" /note="M2 metal binding site" |
E | ||||||||
Additional information
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| Size range | 257-291 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |