 |
|
Annotation rule MF_00558 |
General rule information
[?]
Accession |
MF_00558 |
Dates |
23-MAY-2002 (Created) 18-NOV-2019 (Last updated, Version 32) |
case <OC:Bacteria> or <OC:Archaea>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
|
Full=Succinate--CoA ligase [ADP-forming] subunit beta;
|
|
EC 6.2.1.5;
|
AltName:
|
Full=Succinyl-CoA synthetase subunit beta;
|
|
Short=SCS-beta;
|
|
Function |
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. |
Catalytic activity |
RHEA:17661: ATP + CoA + succinate = ADP + phosphate + succinyl-CoA
EC 6.2.1.5
|
case <FTGroup:1>
Cofactor |
Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
end case
Pathway |
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. |
Subunit |
Heterotetramer of two alpha and two beta subunits. |
Similarity |
Belongs to the succinate/malate CoA ligase beta subunit family. |
case <FTGroup:1>
end case
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0004775; Molecular function: succinate-CoA ligase (ADP-forming) activity.
GO:0006099; Biological process: tricarboxylic acid cycle.
case <Feature:PS50975>
From: SUCC_ECOLI (P0A836) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
9
|
|
244
|
|
ATP-grasp
|
|
|
|
|
|
|
end case
NP_BIND
|
|
53
|
|
55
|
|
ATP
|
|
|
|
G-R-G
|
|
|
REGION
|
|
321
|
|
323
|
|
Substrate binding; shared with subunit alpha
|
|
|
|
G-I-[VAMTL]
|
|
|
METAL
|
|
199
|
|
199
|
|
Magnesium
|
|
|
|
N
|
|
1
|
METAL
|
|
213
|
|
213
|
|
Magnesium
|
|
|
|
D
|
|
1
|
BINDING
|
|
46
|
|
46
|
|
ATP
|
|
|
|
K
|
|
|
BINDING (Optional)
|
|
99
|
|
99
|
|
ATP
|
|
|
|
E
|
|
|
BINDING
|
|
102
|
|
102
|
|
ATP; via amide nitrogen
|
|
|
|
|
|
|
BINDING
|
|
107
|
|
107
|
|
ATP
|
|
|
|
E
|
|
|
BINDING
|
|
264
|
|
264
|
|
Substrate; shared with subunit alpha
|
|
|
|
N
|
|
|
Additional information
[?]
Size range |
364-399 amino acids |
Related rules |
MF_03220 (SUCB1 supersedes the current rule); MF_03221 (SUCB2 supersedes the current rule) |
Fusion |
None |
Comments |
It is not possible to automatically make a distinction between a bona-fide sucC and mtkA (not shown in alignment). |