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Annotation rule MF_00558
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General rule information [?]

Accession MF_00558
Dates 23-MAY-2002 (Created)
18-NOV-2019 (Last updated, Version 32)
Name Succ_CoA_beta
Scope
Bacteria
Archaea
Templates P0A836 (SUCC_ECOLI); P25126 (SUCC_THETH); P80886 (SUCC_BACSU); P53590 (SUCB2_PIG): [Recover all]
case <OC:Bacteria> or <OC:Archaea>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SUCC
Protein name
RecName: Full=Succinate--CoA ligase [ADP-forming] subunit beta;
EC 6.2.1.5;
AltName: Full=Succinyl-CoA synthetase subunit beta;
Short=SCS-beta;
Gene name
sucC

Comments [?]

Function Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Catalytic activity RHEA:17661: ATP + CoA + succinate = ADP + phosphate + succinyl-CoA
EC 6.2.1.5
case <FTGroup:1>
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
end case
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Subunit Heterotetramer of two alpha and two beta subunits.
Similarity Belongs to the succinate/malate CoA ligase beta subunit family.

Keywords [?]

ATP-binding
Ligase
case <FTGroup:1>
Magnesium
Metal-binding
end case
Nucleotide-binding
Tricarboxylic acid cycle

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0004775; Molecular function: succinate-CoA ligase (ADP-forming) activity.
GO:0006099; Biological process: tricarboxylic acid cycle.

Cross-references [?]

PROSITE PS01217; SUCCINYL_COA_LIG_3; 1;
PS50975; ATP_GRASP; 1;
Pfam PF08442; ATP-grasp_2; 1;
PF00549; Ligase_CoA; 1;
TIGRFAMs TIGR01016; SucCoAbeta; 1;
PIRSF PIRSF001554; SucCS_beta; 1;

Features [?]

case <Feature:PS50975>
From: SUCC_ECOLI (P0A836)
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     9     244       ATP-grasp        
end case
NP_BIND     53     55       ATP     G-R-G  
REGION     321     323       Substrate binding; shared with subunit alpha     G-I-[VAMTL]  
METAL     199     199       Magnesium     N   1
METAL     213     213       Magnesium     D   1
BINDING     46     46       ATP     K  
BINDING (Optional)     99     99       ATP     E  
BINDING     102     102       ATP; via amide nitrogen        
BINDING     107     107       ATP     E  
BINDING     264     264       Substrate; shared with subunit alpha     N  

Additional information [?]

Size range 364-399 amino acids
Related rules MF_03220 (SUCB1 supersedes the current rule); MF_03221 (SUCB2 supersedes the current rule)
Fusion None
Comments It is not possible to automatically make a distinction between a bona-fide sucC and mtkA (not shown in alignment).


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