HAMAP rule MF_00558
General rule information
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Accession | MF_00558 |
Dates | 23-MAY-2002 (Created) 1-JUN-2023 (Last updated, Version 37) |
Name | Succ_CoA_beta |
Scope | Bacteria
Archaea |
Templates | P0A836 (SUCC_ECOLI); P25126 (SUCC_THETH); P80886 (SUCC_BACSU); P53590 (SUCB2_PIG): [Recover all] |
case <OC:Bacteria> or <OC:Archaea>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. |
Catalytic activity | RHEA:17661: ATP + CoA + succinate = ADP + phosphate + succinyl-CoA
EC 6.2.1.5 PhysiologicalDirection=right-to-left (RHEA:17663) |
RHEA:22120: CoA + GTP + succinate = GDP + phosphate + succinyl-CoA
PhysiologicalDirection=right-to-left (RHEA:22122) |
case <FTGroup:1>
Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
end case
Pathway | Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. |
Subunit | Heterotetramer of two alpha and two beta subunits. |
Similarity | Belongs to the succinate/malate CoA ligase beta subunit family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0005524; Molecular function: ATP binding.
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0004775; Molecular function: succinate-CoA ligase (ADP-forming) activity.
GO:0006099; Biological process: tricarboxylic acid cycle.
GO:0006099; Biological process: tricarboxylic acid cycle.
Cross-references
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PROSITE | PS01217; SUCCINYL_COA_LIG_3; 1; |
PS50975; ATP_GRASP; 1; | |
Pfam | PF08442; ATP-grasp_2; 1; |
PF00549; Ligase_CoA; 1; | |
NCBIfam | TIGR01016; SucCoAbeta; 1; |
PIRSF | PIRSF001554; SucCS_beta; 1; |
Features
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case <Feature:PS50975>
From: SUCC_ECOLI (P0A836) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | 9 | 244 | ATP-grasp |
end case
Additional information
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Size range | 364-399 amino acids |
Related rules | MF_03220 (SUCB1 supersedes the current rule); MF_03221 (SUCB2 supersedes the current rule) |
Fusion | None |
Comments | It is not possible to automatically make a distinction between a bona-fide sucC and mtkA (not shown in alignment). |