HAMAP rule MF_00567

General rule information [?]

Accession	MF_00567
Dates	2-JUL-2002 (Created) 19-NOV-2022 (Last updated, Version 35)

Name	NadA_type1

Scope

Bacteria

Templates

P11458 (NADA_ECOLI); O57767 (NADA_PYRHO): [Recover all]

Triggered by

HAMAP; MF_00567 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NADA

Protein name

RecName:		Full=Quinolinate synthase;
		EC 2.5.1.72;

Gene name

nadA

Comments [?]

Function	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
Catalytic activity	RHEA:25888: dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate EC 2.5.1.72 PhysiologicalDirection=left-to-right (RHEA:25889)
Cofactor	[4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.
Subcellular location	Cytoplasm.
Similarity	Belongs to the quinolinate synthase family. Type 1 subfamily.

Keywords [?]

4Fe-4S
Cytoplasm
Iron
Iron-sulfur
Metal-binding
Pyridine nucleotide biosynthesis
Transferase

Gene Ontology [?]

GO:0008987; Molecular function: quinolinate synthetase A activity.
GO:0009435; Biological process: NAD biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF02445; NadA; 1;
TIGRFAMs	TIGR00550; nadA; 1;

Features [?]

From: NADA_ECOLI (P11458)

Key From To Description Tag Condition FTGroup

BINDING 139 141 /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875 Y-A-N

BINDING 226 228 /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875 H-P-E

BINDING 113 113 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C

BINDING 200 200 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C

BINDING 297 297 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C

BINDING 47 47 /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875 H

BINDING 68 68 /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875 S

BINDING 156 156 /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875 S

BINDING 243 243 /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875 T

Additional information [?]

Size range	337-382 amino acids
Related rules	MF_00568 (NADA); MF_00569 (NADA)
Fusion	None

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