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HAMAP rule MF_00567

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General rule information [?]

Accession MF_00567
Dates 2-JUL-2002 (Created)
1-JUN-2023 (Last updated, Version 36)
Name NadA_type1
Scope(s) Bacteria
Template(s) P11458 (NADA_ECOLI); O57767 (NADA_PYRHO); [ Recover all ]
Triggered by HAMAP; MF_00567 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NADA
Protein name RecName: Full=Quinolinate synthase;
                 EC=2.5.1.72;
Gene name Name=nadA;

Comments [?]

FUNCTIONCatalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
CATALYTIC ACTIVITY Reaction=dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate; Xref=Rhea:RHEA:25888, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29959, ChEBI:CHEBI:43474, ChEBI:CHEBI:57642, ChEBI:CHEBI:77875; EC=2.5.1.72; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25889;
COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit.;
PATHWAYCofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the quinolinate synthase family. Type 1 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008987; Molecular function:quinolinate synthetase A activity
GO:0009435; Biological process:NAD biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF02445; NadA; 1;
NCBIfam TIGR00550; nadA; 1;

Features [?]

From: NADA_ECOLI (P11458)
Key From To Description Tag Condition FTGroup
BINDING 139 141 /ligand="iminosuccinate"
/ligand_id="ChEBI:CHEBI:77875"
Y-A-N
BINDING 226 228 /ligand="iminosuccinate"
/ligand_id="ChEBI:CHEBI:77875"
H-P-E
BINDING 113 113 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
C
BINDING 200 200 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
C
BINDING 297 297 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
C
BINDING 47 47 /ligand="iminosuccinate"
/ligand_id="ChEBI:CHEBI:77875"
H
BINDING 68 68 /ligand="iminosuccinate"
/ligand_id="ChEBI:CHEBI:77875"
S
BINDING 156 156 /ligand="iminosuccinate"
/ligand_id="ChEBI:CHEBI:77875"
S
BINDING 243 243 /ligand="iminosuccinate"
/ligand_id="ChEBI:CHEBI:77875"
T

Additional information [?]

Size range 337-382 amino acids
Related rules MF_00568
MF_00569
Fusion Nter: None Cter: None



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