HAMAP rule MF_00567
General rule information
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| Accession | MF_00567 |
| Dates | 2-JUL-2002 (Created)
1-JUN-2023 (Last updated, Version 36) |
| Name | NadA_type1 |
| Scope(s) |
Bacteria |
| Template(s) | P11458 (NADA_ECOLI); O57767 (NADA_PYRHO); [ Recover all ] |
| Triggered by |
HAMAP; MF_00567 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NADA |
| Protein name | RecName: Full=Quinolinate synthase; EC=2.5.1.72; |
| Gene name | Name=nadA; |
Comments
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| FUNCTION | Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. |
| CATALYTIC ACTIVITY | Reaction=dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate; Xref=Rhea:RHEA:25888, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29959, ChEBI:CHEBI:43474, ChEBI:CHEBI:57642, ChEBI:CHEBI:77875; EC=2.5.1.72; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25889; |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit.; |
| PATHWAY | Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the quinolinate synthase family. Type 1 subfamily. |
Keywords
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Gene Ontology
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| GO:0008987; Molecular function:quinolinate synthetase A activity |
| GO:0009435; Biological process:NAD biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: NADA_ECOLI (P11458) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 139 | 141 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
Y-A-N | ||||||||
| BINDING | 226 | 228 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
H-P-E | ||||||||
| BINDING | 113 | 113 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 200 | 200 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 297 | 297 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 47 | 47 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
H | ||||||||
| BINDING | 68 | 68 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
S | ||||||||
| BINDING | 156 | 156 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
S | ||||||||
| BINDING | 243 | 243 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
T | ||||||||
Additional information
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| Size range | 337-382 amino acids |
| Related rules |
MF_00568 MF_00569 |
| Fusion | Nter: None Cter: None |