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Annotation rule MF_00567
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General rule information [?]

Accession MF_00567
Dates 2-JUL-2002 (Created)
18-NOV-2019 (Last updated, Version 31)
Name NadA_type1
Scope
Bacteria
Template P11458 (NADA_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NADA
Protein name
RecName: Full=Quinolinate synthase A;
EC 2.5.1.72;
Gene name
nadA

Comments [?]

Function Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
Catalytic activity RHEA:25888: dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate
EC 2.5.1.72
Cofactor [4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the quinolinate synthase A family. Type 1 subfamily.

Keywords [?]

4Fe-4S
Cytoplasm
Iron
Iron-sulfur
Metal-binding
Pyridine nucleotide biosynthesis
Transferase

Gene Ontology [?]

GO:0008987; Molecular function: quinolinate synthetase A activity.
GO:0009435; Biological process: NAD biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF02445; NadA; 1;
TIGRFAMs TIGR00550; NadA; 1;

Features [?]

From: NADA_ECOLI (P11458)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     47     47       Iminoaspartate     H  
BINDING     68     68       Iminoaspartate; via amide nitrogen     S  
BINDING     139     139       Iminoaspartate     Y  
BINDING     156     156       Iminoaspartate     S  
BINDING     226     226       Iminoaspartate     H  
BINDING     243     243       Iminoaspartate     T  

Additional information [?]

Size range 337-382 amino acids
Related rules MF_00568 (NADA); MF_00569 (NADA)
Fusion None


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