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HAMAP rule MF_00567

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General rule information [?]

Accession MF_00567
Dates 2-JUL-2002 (Created)
19-NOV-2022 (Last updated, Version 35)
Name NadA_type1
Templates P11458 (NADA_ECOLI); O57767 (NADA_PYRHO): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Quinolinate synthase;
Gene name

Comments [?]

Function Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
Catalytic activity RHEA:25888: dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate
PhysiologicalDirection=left-to-right (RHEA:25889)
Cofactor [4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.
Subcellular location Cytoplasm.
Similarity Belongs to the quinolinate synthase family. Type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008987; Molecular function: quinolinate synthetase A activity.
GO:0009435; Biological process: NAD biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF02445; NadA; 1;
TIGRFAMs TIGR00550; nadA; 1;

Features [?]

From: NADA_ECOLI (P11458)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     139     141       /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875     Y-A-N  
BINDING     226     228       /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875     H-P-E  
BINDING     113     113       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C  
BINDING     200     200       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C  
BINDING     297     297       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C  
BINDING     47     47       /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875     H  
BINDING     68     68       /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875     S  
BINDING     156     156       /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875     S  
BINDING     243     243       /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875     T  

Additional information [?]

Size range 337-382 amino acids
Related rules MF_00568 (NADA); MF_00569 (NADA)
Fusion None