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HAMAP rule MF_00579

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General rule information [?]

Accession MF_00579
Dates 23-SEP-2002 (Created)
12-MAR-2024 (Last updated, Version 39)
Name FTR
Scope(s) Bacteria
Template(s) Q49610 (FTR_METKA); O28076 (FTR_ARCFU); Q49118 (FHCD_METEA); P55301 (FTR_METBF); [ Recover all ]
Triggered by HAMAP; MF_00579 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FTR
Protein name RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase;
AltName: Full=H4MPT formyltransferase;
case <OC:Archaea>
Gene name Name=ftr;
end case
case <OC:Bacteria>
Gene name Name=ffsA;
end case

Comments [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
FUNCTIONCatalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
FUNCTIONCatalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT).
end case
CATALYTIC ACTIVITY Reaction=5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:18061, ChEBI:CHEBI:15378, ChEBI:CHEBI:57727, ChEBI:CHEBI:58018, ChEBI:CHEBI:58103, ChEBI:CHEBI:58151; EC=;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
PATHWAYOne-carbon metabolism; methanogenesis from CO(2); 5,10- methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3.
end case
case <OC:Archaeoglobales>
PATHWAYMetabolic intermediate metabolism; lactate oxidation.
end case
case <OC:Bacteria>
PATHWAYOne-carbon metabolism; formaldehyde degradation; formate from formaldehyde (H(4)MPT route): step 4/5.
end case
SIMILARITYBelongs to the FTR family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
end case
One-carbon metabolism

Gene Ontology [?]

GO:0030270; Molecular function:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity
GO:0006730; Biological process:one-carbon metabolic process
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0019386; Biological process:methanogenesis, from carbon dioxide
end case
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01913; FTR; 1;
Pfam PF02741; FTR_C; 1;
PIRSF PIRSF006414; Ftr_formyl_trnsf; 1;
NCBIfam TIGR03119; one_C_fhcD; 1;

Features [?]

Additional information [?]

Size range 285-360 amino acids
Related rules None
Fusion Nter: None Cter: None

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