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Annotation rule MF_00579
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General rule information [?]

Accession MF_00579
Dates 23-SEP-2002 (Created)
18-NOV-2019 (Last updated, Version 36)
Name FTR
Templates Q49610 (FTR_METKA); O28076 (FTR_ARCFU); Q49118 (FHCD_METEA); P55301 (FTR_METBF): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase;
AltName: Full=H4MPT formyltransferase;
case <OC:Archaea>
Gene name
end case
case <OC:Bacteria>
Gene name
end case

Comments [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Function Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
Function Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT).
end case
Catalytic activity RHEA:18061: 5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Pathway One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3.
end case
case <OC:Archaeoglobales>
Pathway Metabolic intermediate metabolism; lactate oxidation.
end case
case <OC:Bacteria>
Pathway One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (H(4)MPT route): step 4/5.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the FTR family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
end case

Gene Ontology [?]

GO:0030270; Molecular function: formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity.
GO:0006730; Biological process: one-carbon metabolic process.
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0015948; Biological process: methanogenesis.
end case
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01913; FTR; 1;
PF02741; FTR_C; 1;
PIRSF PIRSF006414; Ftr_formyl_trnsf; 1;
TIGRFAMs TIGR03119; one_C_fhcD; 1;

Additional information [?]

Size range 285-360 amino acids
Related rules None
Fusion None