HAMAP rule MF_00579
General rule information
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| Accession | MF_00579 |
| Dates | 23-SEP-2002 (Created)
4-SEP-2024 (Last updated, Version 43) |
| Name | FTR |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q49610 (FTR_METKA); O28076 (FTR_ARCFU); Q49118 (FHCD_METEA); P55301 (FTR_METBF); [ Recover all ] |
| Triggered by |
HAMAP; MF_00579 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FTR |
| Protein name | RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase; Short=Ftr; EC=2.3.1.101; AltName: Full=H4MPT formyltransferase; |
| case <OC:Archaea> | |
| Gene name | Name=ftr; |
| end case | |
| case <OC:Bacteria> | |
| Gene name | Name=ffsA; |
| end case | |
Comments
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| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| FUNCTION | Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR). |
| else | |
| FUNCTION | Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT). |
| end case | |
| CATALYTIC ACTIVITY | Reaction=N-formylmethanofuran + 5,6,7,8-tetrahydromethanopterin + H(+) = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran; Xref=Rhea:RHEA:18061, ChEBI:CHEBI:15378, ChEBI:CHEBI:57727, ChEBI:CHEBI:58018, ChEBI:CHEBI:58103, ChEBI:CHEBI:58151; EC=2.3.1.101; |
| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| PATHWAY | One-carbon metabolism; methanogenesis from CO(2); 5,10- methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3. |
| end case | |
| case <OC:Archaeoglobales> | |
| PATHWAY | Metabolic intermediate metabolism; lactate oxidation. |
| end case | |
| case <OC:Bacteria> | |
| PATHWAY | One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (H(4)MPT route): step 4/5. |
| end case | |
| SUBUNIT | Homotetramer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the FTR family. |
Keywords
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| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| Methanogenesis | |
| end case | |
| Cytoplasm | |
| One-carbon metabolism | |
| Transferase | |
| Acyltransferase | |
Gene Ontology
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| GO:0030270; Molecular function:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity | |
| GO:0006730; Biological process:one-carbon metabolic process | |
| case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| GO:0019386; Biological process:methanogenesis, from carbon dioxide | |
| end case | |
| case <OCellular component:Archaeoglobales> | |
| GO:0006089; Biological process:lactate metabolic process | |
| end case | |
| case <OCellular component:Bacteria> | |
| GO:0046294; Biological process:formaldehyde catabolic process | |
| end case | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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| Pfam | PF01913; FTR; 1; |
| Pfam | PF02741; FTR_C; 1; |
| PIRSF | PIRSF006414; Ftr_formyl_trnsf; 1; |
| NCBIfam | TIGR03119; one_C_fhcD; 1; |
Features
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Additional information
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| Size range | 285-360 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |