HAMAP rule MF_00587
General rule information
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Accession | MF_00587 |
Dates | 22-OCT-2002 (Created) 19-NOV-2022 (Last updated, Version 28) |
Name | tRNA_methyltr_TrmY |
Scope | Bacteria; Gammaproteobacteria
Archaea |
Templates | Q59034 (TRMY_METJA); D4GTL8 (TRMY_HALVD): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Archaea>
Identifier |
|
Protein name |
|
Gene name |
|
else case <OC:Bacteria>
Identifier |
|
Protein name |
|
end case
Comments
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case <OC:Archaea>
Function | Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs. |
Catalytic activity | RHEA:55292: pseudouridine(54) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine
EC 2.1.1.257 |
Subunit | Homodimer. |
end case
Subcellular location | Cytoplasm. |
Similarity | Belongs to the methyltransferase superfamily. TrmY family. |
Keywords
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case <OC:Archaea>
end case
Gene Ontology
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case <OC:Archaea>
GO:0030488; Biological process: tRNA methylation.
GO:0008175; Molecular function: tRNA methyltransferase activity.
GO:0008175; Molecular function: tRNA methyltransferase activity.
end case
GO:0008757; Molecular function: S-adenosylmethionine-dependent methyltransferase activity.
GO:0005737; Cellular component: cytoplasm.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Pfam | PF04013; Methyltrn_RNA_2; 1; |
Features
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From: TRMY_METJA (Q59034) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 179 | 184 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [LIV]-S-P-L-[ES]-L | ||||||||
BINDING (Optional) | 136 | 136 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [LM] | ||||||||
BINDING (Optional) | 156 | 156 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | G | ||||||||
BINDING (Optional) | 189 | 189 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | C |
Additional information
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Size range | 192-211 amino acids |
Related rules | None |
Fusion | Nter: <Unknown>; Cter: None |
Comments | Formation of 1-methylpseudouridine at position 54 of tRNA has never been identified in any bacterial tRNA sequenced so far. The bacterial and archaeal homologs may fulfill different functions. See PubMed:22274953. Unknown N-terminal domain in ARCFU. Divergent PYRAE not shown in alignment and not used in size range. |