HAMAP rule MF_00590
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00590 |
| Accession | MF_00590 |
| Dates | 28-OCT-2002 (Created)
3-SEP-2024 (Last updated, Version 25) |
| Name | Dephospho_CoA_kinase_GTP_dep |
| Scope(s) |
Archaea |
| Template(s) | Q5JIY7 (DPCKG_THEKO); [ Recover all ] |
| Triggered by |
HAMAP; MF_00590 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DPCKG |
| Protein name | RecName: Full=GTP-dependent dephospho-CoA kinase; EC=2.7.1.237; AltName: Full=Dephospho-coenzyme A kinase; Short=DPCK; |
Comments
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| FUNCTION | Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). |
| CATALYTIC ACTIVITY | Reaction=3'-dephospho-CoA + GTP = GDP + CoA + H(+); Xref=Rhea:RHEA:61156, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:58189; EC=2.7.1.237; |
| PATHWAY | Cofactor biosynthesis; coenzyme A biosynthesis. |
| SIMILARITY | Belongs to the GTP-dependent DPCK family. |
Keywords
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Gene Ontology
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| GO:0016301; Molecular function:kinase activity |
| GO:0005525; Molecular function:GTP binding |
| GO:0015937; Biological process:coenzyme A biosynthetic process |
Cross-references
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| Pfam | PF04019; DUF359; 1; |
| NCBIfam | NF041125; deph_CoA_kin_Thcocales; 1; |
| PIRSF | PIRSF006533; UCP006533; 1; |
Features
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| From: DPCKG_THEKO (Q5JIY7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 48 | 48 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
D | ||||||||
| BINDING | 49 | 49 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
[VLI] | ||||||||
| BINDING | 50 | 50 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
V | ||||||||
| BINDING | 67 | 67 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
D | ||||||||
| BINDING | 69 | 69 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
K | ||||||||
| BINDING | 124 | 124 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
[ED] | ||||||||
| BINDING | 147 | 147 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
[DE] | ||||||||
Additional information
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| Size range | 140-400 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |