HAMAP rule MF_00596

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00596
Accession	MF_00596
Dates	4-NOV-2002 (Created) 3-SEP-2024 (Last updated, Version 29)
Name	GMP_reduct_type1
Scope(s)	Bacteria
Template(s)	P60560 (GUAC_ECOLI); [ Recover all ]
Triggered by	case c? <OC:Bacteria> HAMAP; MF_00596 (Get profile general information and statistics) end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GUAC
Protein name	RecName: Full=GMP reductase; EC=1.7.1.7; AltName: Full=Guanosine 5'-monophosphate oxidoreductase; Short=Guanosine monophosphate reductase;
Gene name	Name=guaC;

Comments [?]

FUNCTION	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
CATALYTIC ACTIVITY	Reaction=IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+); Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115, ChEBI:CHEBI:58349; EC=1.7.1.7;
SUBUNIT	Homotetramer.
SIMILARITY	Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003920; Molecular function:GMP reductase activity

GO:0006163; Biological process:purine nucleotide metabolic process

Cross-references [?]

Features [?]

From: GUAC_ECOLI (P60560)

Key

From

Description

Tag

Condition

FTGroup

BINDING

108

131

/ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"

BINDING

216

239

/ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"

ACT_SITE

186

/note="Thioimidate intermediate"

BINDING

181

/ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"

BINDING

183

/ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"

Additional information [?]