HAMAP rule MF_00596
General rule information
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Accession | MF_00596 |
Dates | 4-NOV-2002 (Created) 1-JUN-2023 (Last updated, Version 28) |
Name | GMP_reduct_type1 |
Scope | Bacteria |
Template | P60560 (GUAC_ECOLI) |
case <OC:Bacteria>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. |
Catalytic activity | RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH
EC 1.7.1.7 |
Subunit | Homotetramer. |
Similarity | Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. |
Keywords
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Gene Ontology
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GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.
GO:0006163; Biological process: purine nucleotide metabolic process.
Cross-references
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Pfam | PF00478; IMPDH; 1; |
PIRSF | PIRSF000235; GMP_reductase; 1; |
NCBIfam | TIGR01305; GMP_reduct_1; 1; |
PROSITE | PS00487; IMP_DH_GMP_RED; 1; |
Features
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From: GUAC_ECOLI (P60560) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 108 | 131 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | |||||||||
BINDING | 216 | 239 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | |||||||||
ACT_SITE | 186 | 186 | Thioimidate intermediate | C | ||||||||
BINDING | 181 | 181 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 | G | ||||||||
BINDING | 183 | 183 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 | G |
Additional information
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Size range | 347-351 amino acids |
Related rules | None |
Fusion | None |