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Annotation rule MF_00596
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General rule information [?]

Accession MF_00596
Dates 4-NOV-2002 (Created)
18-NOV-2019 (Last updated, Version 25)
Name GMP_reduct_type1
Scope
Bacteria
Template P60560 (GUAC_ECOLI)
case <OC:Bacteria>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GUAC
Protein name
RecName: Full=GMP reductase;
EC 1.7.1.7;
AltName: Full=Guanosine 5'-monophosphate oxidoreductase;
Short=Guanosine monophosphate reductase;
Gene name
guaC

Comments [?]

Function Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Catalytic activity RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH
EC 1.7.1.7
Subunit Homotetramer.
Similarity Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Keywords [?]

Oxidoreductase
NADP
Metal-binding
Potassium

Gene Ontology [?]

GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.

Cross-references [?]

Pfam PF00478; IMPDH; 1;
PIRSF PIRSF000235; GMP_reductase; 1;
TIGRFAMs TIGR01305; GMP_reduct_1; 1;
PROSITE PS00487; IMP_DH_GMP_RED; 1;

Features [?]

From: GUAC_ECOLI (P60560)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     108     131       NADP        
NP_BIND     216     239       NADP; ribose moiety        
ACT_SITE     186     186       Thioimidate intermediate     C  
METAL     181     181       Potassium; via carbonyl oxygen     G  
METAL     183     183       Potassium; via carbonyl oxygen     G  

Additional information [?]

Size range 347-351 amino acids
Related rules None
Fusion None


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