HAMAP rule MF_00596

General rule information [?]

Accession	MF_00596
Dates	4-NOV-2002 (Created) 1-JUN-2023 (Last updated, Version 28)

Name	GMP_reduct_type1

Scope

Bacteria

Template

P60560 (GUAC_ECOLI)

case <OC:Bacteria>

Triggered by

end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GUAC

Protein name

RecName:		Full=GMP reductase;
		EC 1.7.1.7;
AltName:		Full=Guanosine 5'-monophosphate oxidoreductase;
		Short=Guanosine monophosphate reductase;

Gene name

guaC

Comments [?]

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Catalytic activity	RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH EC 1.7.1.7
Subunit	Homotetramer.
Similarity	Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.

Cross-references [?]

Features [?]

From: GUAC_ECOLI (P60560)

Key From To Description Tag Condition FTGroup

BINDING 108 131 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349

BINDING 216 239 /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349

ACT_SITE 186 186 Thioimidate intermediate C

BINDING 181 181 /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 G

BINDING 183 183 /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 G

Additional information [?]