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Annotation rule MF_00596 |
Accession | MF_00596 |
Dates | 4-NOV-2002 (Created) 18-NOV-2019 (Last updated, Version 25) |
Name | GMP_reduct_type1 |
Scope | Bacteria |
Template | P60560 (GUAC_ECOLI) |
Triggered by |
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Protein name |
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Gene name |
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Function | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. |
Catalytic activity | RHEA:17185: IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH
EC 1.7.1.7 |
Subunit | Homotetramer. |
Similarity | Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. |
Pfam | PF00478; IMPDH; 1; |
PIRSF | PIRSF000235; GMP_reductase; 1; |
TIGRFAMs | TIGR01305; GMP_reduct_1; 1; |
PROSITE | PS00487; IMP_DH_GMP_RED; 1; |
From: GUAC_ECOLI (P60560) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 108 | 131 | NADP | |||||||||
NP_BIND | 216 | 239 | NADP; ribose moiety | |||||||||
ACT_SITE | 186 | 186 | Thioimidate intermediate | C | ||||||||
METAL | 181 | 181 | Potassium; via carbonyl oxygen | G | ||||||||
METAL | 183 | 183 | Potassium; via carbonyl oxygen | G |
Size range | 347-351 amino acids |
Related rules | None |
Fusion | None |