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HAMAP rule MF_00596

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General rule information [?]

Accession MF_00596
Dates 4-NOV-2002 (Created)
1-JUN-2023 (Last updated, Version 28)
Name GMP_reduct_type1
Scope(s) Bacteria
Template(s) P60560 (GUAC_ECOLI); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_00596 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GUAC
Protein name RecName: Full=GMP reductase;
                 EC=1.7.1.7;
AltName: Full=Guanosine 5'-monophosphate oxidoreductase;
                 Short=Guanosine monophosphate reductase;
Gene name Name=guaC;

Comments [?]

FUNCTIONCatalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
CATALYTIC ACTIVITY Reaction=IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH; Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115, ChEBI:CHEBI:58349; EC=1.7.1.7;
SUBUNITHomotetramer.
SIMILARITYBelongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0003920; Molecular function:GMP reductase activity
GO:0006163; Biological process:purine nucleotide metabolic process

Cross-references [?]

Pfam PF00478; IMPDH; 1;
PIRSF PIRSF000235; GMP_reductase; 1;
NCBIfam TIGR01305; GMP_reduct_1; 1;
PROSITE PS00487; IMP_DH_GMP_RED; 1;

Features [?]

From: GUAC_ECOLI (P60560)
Key From To Description Tag Condition FTGroup
BINDING 108 131 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
BINDING 216 239 /ligand="NADP(+)"
/ligand_id="ChEBI:CHEBI:58349"
ACT_SITE 186 186 /note="Thioimidate intermediate" C
BINDING 181 181 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"
G
BINDING 183 183 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"
G

Additional information [?]

Size range 347-351 amino acids
Related rules None
Fusion Nter: None Cter: None



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