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HAMAP rule MF_00602

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General rule information [?]

Accession MF_00602
Dates 19-NOV-2002 (Created)
19-NOV-2022 (Last updated, Version 27)
Name Prot_Arg_kinase
Scope
Bacteria
Templates P37570 (MCSB_BACSU); P0DMM5 (MCSB_GEOSE): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MCSB
Protein name
RecName: Full=Protein-arginine kinase;
EC 2.7.14.1;
Gene name
mcsB

Comments [?]

case <OC:Bacillaceae>
Function Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.
else
Function Catalyzes the specific phosphorylation of arginine residues in proteins.
end case
Catalytic activity RHEA:43384: ATP + L-arginyl-[protein] = ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]
EC 2.7.14.1
case <FTTag:Motif>
Activity regulation Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.
end case
Similarity Belongs to the ATP:guanido phosphotransferase family.

Keywords [?]

case <FTTag:Motif>
end case

Gene Ontology [?]

GO:0016775; Molecular function: phosphotransferase activity, nitrogenous group as acceptor.
GO:0004672; Molecular function: protein kinase activity.

Cross-references [?]

Pfam PF00217; ATP-gua_Ptrans; 1;
PROSITE PS00112; PHOSPHAGEN_KINASE; 1;
PS51510; PHOSPHAGEN_KINASE_C; 1; trigger=PRU00843;

Features [?]

From: MCSB_BACSU (P37570)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     27     31       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [SAT]-[SAT]-[RK]-[VI]-[RK]  
BINDING (Optional)     176     180       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     R-[AT]-[SK]-[VATL]-[MF]  
BINDING (Optional)     207     212       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [RK]-[GS]-[TIL]-x-[GN]-[ES]  
BINDING (Optional)     92     92       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     H  
BINDING (Optional)     125     125       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     R  
MOTIF (Optional)     337     342       RDXXRA motif of the pArg binding pocket involved in allosteric regulation   Motif   R-D-x-x-R-A  

Additional information [?]

Size range 335-363 amino acids
Related rules None
Fusion None