HAMAP rule MF_00602
General rule information
[?]
Accession | MF_00602 |
Dates | 19-NOV-2002 (Created) 19-NOV-2022 (Last updated, Version 27) |
Name | Prot_Arg_kinase |
Scope | Bacteria |
Templates | P37570 (MCSB_BACSU); P0DMM5 (MCSB_GEOSE): [Recover all] |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Gene name |
|
Comments
[?]
case <OC:Bacillaceae>
Function | Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity. |
else
Function | Catalyzes the specific phosphorylation of arginine residues in proteins. |
end case
Catalytic activity | RHEA:43384: ATP + L-arginyl-[protein] = ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]
EC 2.7.14.1 |
case <FTTag:Motif>
Activity regulation | Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB. |
end case
Similarity | Belongs to the ATP:guanido phosphotransferase family. |
Keywords
[?]
case <FTTag:Motif>
end case
Gene Ontology
[?]
GO:0016775; Molecular function: phosphotransferase activity, nitrogenous group as acceptor.
GO:0004672; Molecular function: protein kinase activity.
GO:0004672; Molecular function: protein kinase activity.
Cross-references
[?]
Pfam | PF00217; ATP-gua_Ptrans; 1; |
PROSITE | PS00112; PHOSPHAGEN_KINASE; 1; |
PS51510; PHOSPHAGEN_KINASE_C; 1; trigger=PRU00843; |
Features
[?]
From: MCSB_BACSU (P37570) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 27 | 31 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [SAT]-[SAT]-[RK]-[VI]-[RK] | ||||||||
BINDING (Optional) | 176 | 180 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | R-[AT]-[SK]-[VATL]-[MF] | ||||||||
BINDING (Optional) | 207 | 212 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [RK]-[GS]-[TIL]-x-[GN]-[ES] | ||||||||
BINDING (Optional) | 92 | 92 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | H | ||||||||
BINDING (Optional) | 125 | 125 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | R | ||||||||
MOTIF (Optional) | 337 | 342 | RDXXRA motif of the pArg binding pocket involved in allosteric regulation | Motif | R-D-x-x-R-A |
Additional information
[?]
Size range | 335-363 amino acids |
Related rules | None |
Fusion | None |