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HAMAP rule MF_00602

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General rule information [?]

Accession MF_00602
Dates 19-NOV-2002 (Created)
19-NOV-2022 (Last updated, Version 27)
Name Prot_Arg_kinase
Scope(s) Bacteria
Template(s) P37570 (MCSB_BACSU); P0DMM5 (MCSB_GEOSE); [ Recover all ]
Triggered by HAMAP; MF_00602 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MCSB
Protein name RecName: Full=Protein-arginine kinase;
Gene name Name=mcsB;

Comments [?]

case <OC:Bacillaceae>
FUNCTIONCatalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.
FUNCTIONCatalyzes the specific phosphorylation of arginine residues in proteins.
end case
CATALYTIC ACTIVITY Reaction=ATP + L-arginyl-[protein] = ADP + H(+) + N(omega)-phospho-L- arginyl-[protein]; Xref=Rhea:RHEA:43384, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:10533, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:30616, ChEBI:CHEBI:83226, ChEBI:CHEBI:456216; EC=;
case <FTTag:Motif>
ACTIVITY REGULATIONAppears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.
end case
SIMILARITYBelongs to the ATP:guanido phosphotransferase family.

Keywords [?]

Gene Ontology [?]

GO:0016775; Molecular function:phosphotransferase activity, nitrogenous group as acceptor
GO:0004672; Molecular function:protein kinase activity

Cross-references [?]

Pfam PF00217; ATP-gua_Ptrans; 1;

Features [?]

From: MCSB_BACSU (P37570)
Key From To Description Tag Condition FTGroup
BINDING 27 31 /ligand="ATP"
BINDING 176 180 /ligand="ATP"
BINDING 207 212 /ligand="ATP"
BINDING 92 92 /ligand="ATP"
BINDING 125 125 /ligand="ATP"
MOTIF 337 342 /note="RDXXRA motif of the pArg binding pocket involved in allosteric regulation" Motif R-D-x-x-R-A

Additional information [?]

Size range 335-363 amino acids
Related rules None
Fusion Nter: None Cter: None

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