HAMAP rule MF_00602

General rule information [?]

Accession	MF_00602
Dates	19-NOV-2002 (Created) 19-NOV-2022 (Last updated, Version 27)

Name	Prot_Arg_kinase

Scope

Bacteria

Templates

P37570 (MCSB_BACSU); P0DMM5 (MCSB_GEOSE): [Recover all]

Triggered by

HAMAP; MF_00602 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MCSB

Protein name

RecName:		Full=Protein-arginine kinase;
		EC 2.7.14.1;

Gene name

mcsB

Comments [?]

case <OC:Bacillaceae>

Function

Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.

else

Function

Catalyzes the specific phosphorylation of arginine residues in proteins.

end case

Catalytic activity

RHEA:43384: ATP + L-arginyl-[protein] = ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]
EC 2.7.14.1

case <FTTag:Motif>

Activity regulation

Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.

end case

Similarity

Belongs to the ATP:guanido phosphotransferase family.

Keywords [?]

ATP-binding
Kinase
Nucleotide-binding
Transferase

case <FTTag:Motif>

Allosteric enzyme

end case

Gene Ontology [?]

GO:0016775; Molecular function: phosphotransferase activity, nitrogenous group as acceptor.
GO:0004672; Molecular function: protein kinase activity.

Cross-references [?]

Pfam	PF00217; ATP-gua_Ptrans; 1;
PROSITE	PS00112; PHOSPHAGEN_KINASE; 1;
	PS51510; PHOSPHAGEN_KINASE_C; 1; trigger=PRU00843;

Features [?]

From: MCSB_BACSU (P37570)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 27 31 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [SAT]-[SAT]-[RK]-[VI]-[RK]

BINDING (Optional) 176 180 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 R-[AT]-[SK]-[VATL]-[MF]

BINDING (Optional) 207 212 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [RK]-[GS]-[TIL]-x-[GN]-[ES]

BINDING (Optional) 92 92 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 H

BINDING (Optional) 125 125 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 R

MOTIF (Optional) 337 342 RDXXRA motif of the pArg binding pocket involved in allosteric regulation Motif R-D-x-x-R-A

Additional information [?]

Size range	335-363 amino acids
Related rules	None
Fusion	None

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