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HAMAP rule MF_00615

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General rule information [?]

Accession MF_00615
Dates 5-FEB-2003 (Created)
19-NOV-2022 (Last updated, Version 26)
Name RNApol_arch_Rpo12
Scope
Archaea
Templates Q97ZX7 (RPO12_SACS2); Q4JAE8 (RPO12_SULAC); B8YB64 (RPO12_SACSH): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RPO12
Protein name
RecName: Full=DNA-directed RNA polymerase subunit Rpo12;
EC 2.7.7.6;
AltName: Full=DNA-directed RNA polymerase subunit P;
Gene name
rpo12, rpoP

Comments [?]

Function DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Catalytic activity RHEA:21248: a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
EC 2.7.7.6
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion.
end case
Subunit Part of the RNA polymerase complex.
Subcellular location Cytoplasm.
Similarity Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

Keywords [?]

Cytoplasm
Transferase
Nucleotidyltransferase
DNA-directed RNA polymerase
Transcription
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0003899; Molecular function: DNA-directed 5'-3' RNA polymerase activity.
GO:0006351; Biological process: DNA-templated transcription.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

Pfam PF03604; DNA_RNApol_7kD; 1;

Features [?]

From: RPO12_SACS2 (Q97ZX7)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     9     9       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     26     26       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     29     29       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1

Additional information [?]

Size range 43-81 amino acids
Related rules None
Fusion None
Comments Although Cys-6 is appropriately positioned to be the 4th Zn ligand, it has not been seen to do so in any of the structures as of June 2021.


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