HAMAP rule MF_00615
General rule information
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Accession | MF_00615 |
Dates | 5-FEB-2003 (Created) 19-NOV-2022 (Last updated, Version 26) |
Name | RNApol_arch_Rpo12 |
Scope | Archaea |
Templates | Q97ZX7 (RPO12_SACS2); Q4JAE8 (RPO12_SULAC); B8YB64 (RPO12_SACSH): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. |
Catalytic activity | RHEA:21248: a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
EC 2.7.7.6 |
case <FTGroup:1>
Cofactor | Zn(2+) Note: Binds 1 zinc ion. |
end case
Subunit | Part of the RNA polymerase complex. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0005737; Cellular component: cytoplasm.
GO:0003899; Molecular function: DNA-directed 5'-3' RNA polymerase activity.
GO:0006351; Biological process: DNA-templated transcription.
GO:0003899; Molecular function: DNA-directed 5'-3' RNA polymerase activity.
GO:0006351; Biological process: DNA-templated transcription.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
Cross-references
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Pfam | PF03604; DNA_RNApol_7kD; 1; |
Features
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From: RPO12_SACS2 (Q97ZX7) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 9 | 9 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING | 26 | 26 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 | |||||||
BINDING | 29 | 29 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | C | 1 |
Additional information
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Size range | 43-81 amino acids |
Related rules | None |
Fusion | None |
Comments | Although Cys-6 is appropriately positioned to be the 4th Zn ligand, it has not been seen to do so in any of the structures as of June 2021. |