HAMAP rule MF_00616

General rule information [?]

Accession	MF_00616
Dates	6-FEB-2003 (Created) 2-SEP-2024 (Last updated, Version 26)
Name	Ureidogly_lyase
Scope(s)	Bacteria
Template(s)	P77731 (ALLA_ECOLI); B1XFU0 (ALLA_ECODH); [ Recover all ]
Triggered by	HAMAP; MF_00616 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ALLA
Protein name	RecName: Full=Ureidoglycolate lyase; EC=4.3.2.3; AltName: Full=Ureidoglycolatase;
Gene name	Name=allA;

Comments [?]

case <OC:Escherichia> or <OC:Shigella>
FUNCTION	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.
else
FUNCTION	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source.
end case
CATALYTIC ACTIVITY	Reaction=(S)-ureidoglycolate = urea + glyoxylate; Xref=Rhea:RHEA:11304, ChEBI:CHEBI:16199, ChEBI:CHEBI:36655, ChEBI:CHEBI:57296; EC=4.3.2.3;
COFACTOR	Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
PATHWAY	Nitrogen metabolism; (S)-allantoin degradation.
SUBUNIT	Homodimer.
SIMILARITY	Belongs to the ureidoglycolate lyase family.

Keywords [?]

Gene Ontology [?]

GO:0050385; Molecular function:ureidoglycolate lyase activity

GO:0000256; Biological process:allantoin catabolic process

GO:0006145; Biological process:purine nucleobase catabolic process

Cross-references [?]

Pfam	PF04115; Ureidogly_hydro; 1;
PIRSF	PIRSF017306; Ureidogly_hydro; 1;

Features [?]

Additional information [?]