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HAMAP rule MF_00616

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General rule information [?]

Accession MF_00616
Dates 6-FEB-2003 (Created)
18-NOV-2019 (Last updated, Version 25)
Name Ureidogly_lyase
Scope(s) Bacteria
Template(s) P77731 (ALLA_ECOLI); B1XFU0 (ALLA_ECODH); [ Recover all ]
Triggered by HAMAP; MF_00616 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ALLA
Protein name RecName: Full=Ureidoglycolate lyase;
                 EC=4.3.2.3;
AltName: Full=Ureidoglycolatase;
Gene name Name=allA;

Comments [?]

case <OC:Escherichia> or <OC:Shigella>
FUNCTIONCatalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.
else
FUNCTIONCatalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source.
end case
CATALYTIC ACTIVITY Reaction=(S)-ureidoglycolate = glyoxylate + urea; Xref=Rhea:RHEA:11304, ChEBI:CHEBI:16199, ChEBI:CHEBI:36655, ChEBI:CHEBI:57296; EC=4.3.2.3;
COFACTOR Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
PATHWAYNitrogen metabolism; (S)-allantoin degradation.
SUBUNITHomodimer.
SIMILARITYBelongs to the ureidoglycolate lyase family.

Keywords [?]


Gene Ontology [?]

GO:0050385; Molecular function:ureidoglycolate lyase activity
GO:0000256; Biological process:allantoin catabolic process
GO:0006145; Biological process:purine nucleobase catabolic process

Cross-references [?]

Pfam PF04115; Ureidogly_hydro; 1;
PIRSF PIRSF017306; Ureidogly_hydro; 1;

Features [?]


Additional information [?]

Size range 160-177 amino acids
Related rules None
Fusion Nter: None Cter: None



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