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Annotation rule MF_00621
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General rule information [?]

Accession MF_00621
Dates 27-FEB-2003 (Created)
18-NOV-2019 (Last updated, Version 26)
Name HTH_type_CodY
Templates P39779 (CODY_BACSU); Q9CJ45 (CODY_LACLA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY;
Gene name

Comments [?]

Function DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.
Subcellular location Cytoplasm.
Similarity Belongs to the CodY family.

Keywords [?]

case <FT:2>
end case

Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0045892; Biological process: negative regulation of transcription, DNA-templated.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF06018; CodY; 1;
PF08222; HTH_CodY; 1;
TIGRFAMs TIGR02787; CodY_Gpos; 1;
PIRSF PIRSF011572; GTP_sensing_CodY; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
DNA_BIND     206     225       H-T-H motif        
case <OC:Bacillaceae>
From: CODY_BACSU (P39779)
MOD_RES     215     215       Phosphoserine     S  
end case

Additional information [?]

Size range 250-262 amino acids
Related rules None
Fusion None