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Annotation rule MF_00624
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General rule information [?]

Accession MF_00624
Dates 11-MAR-2003 (Created)
18-NOV-2019 (Last updated, Version 26)
Name GlgC
Scope
Bacteria
Templates P0A6V1 (GLGC_ECOLI); P30521 (GLGC_NOSS1); P9WN43 (GLGC_MYCTU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GLGC
Protein name
RecName: Full=Glucose-1-phosphate adenylyltransferase;
EC 2.7.7.27;
AltName: Full=ADP-glucose pyrophosphorylase;
Short=ADPGlc PPase;
AltName: Full=ADP-glucose synthase;
Gene name
glgC

Comments [?]

case <OC:Mycobacterium>
Function Involved in the biosynthesis of ADP-glucose, a building block, required in the biosynthesis of maltose-1-phosphate (M1P) and in the elongation reactions to produce linear alpha-1,4-glucans. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
else
Function Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
end case
Catalytic activity RHEA:12120: alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate
EC 2.7.7.27
Pathway Glycan biosynthesis; glycogen biosynthesis.
case <OC:Enterobacteriaceae>
Activity regulation Allosterically activated by fructose-1,6-bisphosphate (F16BP) and inhibited by AMP.
end case
case not <OC:Mycobacterium>
Subunit Homotetramer.
end case
Similarity Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

Keywords [?]

ATP-binding
Carbohydrate metabolism
Glycogen biosynthesis
Glycogen metabolism
Nucleotide-binding
Nucleotidyltransferase
Transferase
case <OC:Enterobacteriaceae>
Allosteric enzyme
end case

Gene Ontology [?]

GO:0008878; Molecular function: glucose-1-phosphate adenylyltransferase activity.
GO:0005978; Biological process: glycogen biosynthetic process.

Cross-references [?]

Pfam PF00483; NTP_transferase; 1;
PF00132; Hexapep; 0-4;
TIGRFAMs TIGR02091; GlgC; 1;
PROSITE PS00808; ADP_GLC_PYROPHOSPH_1; 1;
PS00809; ADP_GLC_PYROPHOSPH_2; 1;
PS00810; ADP_GLC_PYROPHOSPH_3; 1;

Features [?]

From: GLGC_ECOLI (P0A6V1)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     194     195       Alpha-D-glucose 1-phosphate binding     E-K  
case <OC:Enterobacteriaceae>
REGION     419     423       Fructose-1,6-bisphosphate binding     R-[ED]-x(2)-R  
REGION     429     431       Fructose-1,6-bisphosphate binding     Q-E-R  
BINDING     39     39       Fructose-1,6-bisphosphate     K  
BINDING     40     40       AMP     R  
BINDING     46     46       AMP     H  
BINDING     52     52       AMP     R  
end case
BINDING     114     114       Alpha-D-glucose 1-phosphate     Y  
case <OC:Enterobacteriaceae>
BINDING     130     130       AMP     R  
end case
BINDING     179     179       Alpha-D-glucose 1-phosphate; via amide nitrogen     G  
BINDING     212     212       Alpha-D-glucose 1-phosphate; via carbonyl oxygen     S  
case <OC:Enterobacteriaceae>
BINDING     370     370       AMP     [ED]  
BINDING     386     386       AMP     [RK]  
end case
SITE     74     74       Could play a key role in the communication between the regulatory and the substrate sites     Q  
SITE     113     113       Could play a key role in the communication between the regulatory and the substrate sites     [WF]  

Additional information [?]

Size range 376-476 amino acids
Related rules None
Fusion None
Comments GlgC from M.tuberculosis is involved in the biosynthesis of both glycogen and capsular alpha-D-glucan.


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