HAMAP rule MF_00624
General rule information
[?]
| Accession | MF_00624 |
| Dates | 11-MAR-2003 (Created)
1-JUN-2023 (Last updated, Version 30) |
| Name | GlgC |
| Scope(s) |
Bacteria |
| Template(s) | P0A6V1 (GLGC_ECOLI); P30521 (GLGC_NOSS1); P9WN43 (GLGC_MYCTU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00624 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | GLGC |
| Protein name | RecName: Full=Glucose-1-phosphate adenylyltransferase; EC=2.7.7.27; AltName: Full=ADP-glucose pyrophosphorylase; Short=ADPGlc PPase; AltName: Full=ADP-glucose synthase; |
| Gene name | Name=glgC; |
Comments
[?]
| case <OC:Mycobacterium> | |
| FUNCTION | Involved in the biosynthesis of ADP-glucose, a building block, required in the biosynthesis of maltose-1-phosphate (M1P) and in the elongation reactions to produce linear alpha-1,4-glucans. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. |
| else | |
| FUNCTION | Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate; Xref=Rhea:RHEA:12120, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57498, ChEBI:CHEBI:58601; EC=2.7.7.27; |
| PATHWAY | Glycan biosynthesis; glycogen biosynthesis. |
| case <OC:Enterobacteriaceae> | |
| ACTIVITY REGULATION | Allosterically activated by fructose-1,6- bisphosphate (F16BP) and inhibited by AMP. |
| end case | |
| case not <OC:Mycobacterium> | |
| SUBUNIT | Homotetramer. |
| end case | |
| SIMILARITY | Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. |
Keywords
[?]
| ATP-binding | |
| Carbohydrate metabolism | |
| Glycogen biosynthesis | |
| Glycogen metabolism | |
| Nucleotide-binding | |
| Nucleotidyltransferase | |
| Transferase | |
| case <OC:Enterobacteriaceae> | |
| Allosteric enzyme | |
| end case | |
Gene Ontology
[?]
| GO:0008878; Molecular function:glucose-1-phosphate adenylyltransferase activity |
| GO:0005978; Biological process:glycogen biosynthetic process |
Cross-references
[?]
| Pfam | PF00483; NTP_transferase; 1; |
| Pfam | PF00132; Hexapep; 0-4; |
| NCBIfam | TIGR02091; GlgC; 1; |
| PROSITE | PS00808; ADP_GLC_PYROPHOSPH_1; 1; |
| PROSITE | PS00809; ADP_GLC_PYROPHOSPH_2; 1; |
| PROSITE | PS00810; ADP_GLC_PYROPHOSPH_3; 1; |
Features
[?]
| From: GLGC_ECOLI (P0A6V1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 194 | 195 | /ligand="alpha-D-glucose 1-phosphate" /ligand_id="ChEBI:CHEBI:58601" |
E-K | ||||||||
| case <OC:Enterobacteriaceae> | ||||||||||||
| BINDING | 419 | 423 | /ligand="beta-D-fructose 1,6-bisphosphate" /ligand_id="ChEBI:CHEBI:32966" |
R-[ED]-x(2)-R | ||||||||
| BINDING | 429 | 431 | /ligand="beta-D-fructose 1,6-bisphosphate" /ligand_id="ChEBI:CHEBI:32966" |
Q-E-R | ||||||||
| BINDING | 39 | 39 | /ligand="beta-D-fructose 1,6-bisphosphate" /ligand_id="ChEBI:CHEBI:32966" |
K | ||||||||
| BINDING | 40 | 40 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
R | ||||||||
| BINDING | 46 | 46 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
H | ||||||||
| BINDING | 52 | 52 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
R | ||||||||
| end case | ||||||||||||
| BINDING | 114 | 114 | /ligand="alpha-D-glucose 1-phosphate" /ligand_id="ChEBI:CHEBI:58601" |
Y | ||||||||
| case <OC:Enterobacteriaceae> | ||||||||||||
| BINDING | 130 | 130 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
R | ||||||||
| end case | ||||||||||||
| BINDING | 179 | 179 | /ligand="alpha-D-glucose 1-phosphate" /ligand_id="ChEBI:CHEBI:58601" |
G | ||||||||
| BINDING | 212 | 212 | /ligand="alpha-D-glucose 1-phosphate" /ligand_id="ChEBI:CHEBI:58601" |
S | ||||||||
| case <OC:Enterobacteriaceae> | ||||||||||||
| BINDING | 370 | 370 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
[ED] | ||||||||
| BINDING | 386 | 386 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215" |
[RK] | ||||||||
| end case | ||||||||||||
| SITE | 74 | 74 | /note="Could play a key role in the communication between the regulatory and the substrate sites" | Q | ||||||||
| SITE | 113 | 113 | /note="Could play a key role in the communication between the regulatory and the substrate sites" | [WF] | ||||||||
Additional information
[?]
| Size range | 376-476 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | GlgC from M.tuberculosis is involved in the biosynthesis of both glycogen and capsular alpha-D-glucan. |