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Annotation rule MF_00624 |
General rule information
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Accession |
MF_00624 |
Dates |
11-MAR-2003 (Created) 18-NOV-2019 (Last updated, Version 26) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Glucose-1-phosphate adenylyltransferase;
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EC 2.7.7.27;
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AltName:
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Full=ADP-glucose pyrophosphorylase;
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Short=ADPGlc PPase;
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AltName:
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Full=ADP-glucose synthase;
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case <OC:Mycobacterium>
Function |
Involved in the biosynthesis of ADP-glucose, a building block, required in the biosynthesis of maltose-1-phosphate (M1P) and in the elongation reactions to produce linear alpha-1,4-glucans. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. |
else
Function |
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. |
end case
Catalytic activity |
RHEA:12120: alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate
EC 2.7.7.27
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Pathway |
Glycan biosynthesis; glycogen biosynthesis. |
case <OC:Enterobacteriaceae>
Activity regulation |
Allosterically activated by fructose-1,6-bisphosphate (F16BP) and inhibited by AMP. |
end case
case not <OC:Mycobacterium>
end case
Similarity |
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. |
case <OC:Enterobacteriaceae>
end case
GO:0008878; Molecular function: glucose-1-phosphate adenylyltransferase activity.
GO:0005978; Biological process: glycogen biosynthetic process.
From: GLGC_ECOLI (P0A6V1) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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REGION
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194
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195
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Alpha-D-glucose 1-phosphate binding
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E-K
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case <OC:Enterobacteriaceae>
REGION
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419
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423
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Fructose-1,6-bisphosphate binding
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R-[ED]-x(2)-R
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REGION
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429
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431
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Fructose-1,6-bisphosphate binding
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Q-E-R
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BINDING
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39
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39
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Fructose-1,6-bisphosphate
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K
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BINDING
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40
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40
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AMP
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R
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BINDING
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46
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46
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AMP
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H
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BINDING
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52
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52
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AMP
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R
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end case
BINDING
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114
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114
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Alpha-D-glucose 1-phosphate
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Y
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case <OC:Enterobacteriaceae>
end case
BINDING
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179
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179
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Alpha-D-glucose 1-phosphate; via amide nitrogen
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G
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BINDING
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212
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212
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Alpha-D-glucose 1-phosphate; via carbonyl oxygen
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S
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case <OC:Enterobacteriaceae>
BINDING
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370
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370
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AMP
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[ED]
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BINDING
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386
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386
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AMP
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[RK]
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end case
SITE
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74
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74
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Could play a key role in the communication between the regulatory and the substrate sites
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Q
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SITE
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113
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113
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Could play a key role in the communication between the regulatory and the substrate sites
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[WF]
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Additional information
[?]
Size range |
376-476 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
GlgC from M.tuberculosis is involved in the biosynthesis of both glycogen and capsular alpha-D-glucan. |