HAMAP rule MF_00628

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00628
Accession	MF_00628
Dates	28-FEB-2005 (Created) 21-MAR-2025 (Last updated, Version 18)
Name	Pept_tRNA_hydro_arch
Scope(s)	Archaea
Template(s)	Q60363; Q980V1; [ Recover all ]
Triggered by	HAMAP; MF_00628 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PTH
Protein name	RecName: Full=Peptidyl-tRNA hydrolase; Short=PTH; EC=3.1.1.29;
Gene name	Name=pth;

Comments [?]

FUNCTION	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
CATALYTIC ACTIVITY	Reaction=an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+); Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123, Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191; EC=3.1.1.29;
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the PTH2 family.

Keywords [?]

Gene Ontology [?]

GO:0004045; Molecular function:peptidyl-tRNA hydrolase activity

GO:0006412; Biological process:translation

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam	PF01981; PTH2; 1;
NCBIfam	TIGR00283; Arch_pth2; 1;

Features [?]

Additional information [?]