HAMAP rule MF_00638
General rule information
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Accession | MF_00638 |
Dates | 17-APR-2003 (Created) 1-JUN-2023 (Last updated, Version 19) |
Name | Anti_sigma_B |
Scope | Bacteria; Bacillales |
Template | P17904 (RSBW_BACSU) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). |
Catalytic activity | RHEA:17989: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
EC 2.7.11.1 |
RHEA:46608: ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
EC 2.7.11.1 |
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Similarity | Belongs to the anti-sigma-factor family. |
Keywords
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Gene Ontology
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GO:0004672; Molecular function: protein kinase activity.
GO:0010468; Biological process: regulation of gene expression.
GO:0010468; Biological process: regulation of gene expression.
Cross-references
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Additional information
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Size range | 157-162 amino acids |
Related rules | MF_00637 (SP2AB) |
Fusion | None |