HAMAP rule MF_00638

General rule information [?]

Accession	MF_00638
Dates	17-APR-2003 (Created) 1-JUN-2023 (Last updated, Version 19)

Name	Anti_sigma_B

Scope

Bacteria; Bacillales

Template

P17904 (RSBW_BACSU)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

RSBW

Protein name

RecName:		Full=Serine-protein kinase RsbW;
		EC 2.7.11.1;
AltName:		Full=Anti-sigma-B factor;
AltName:		Full=Sigma-B negative effector RsbW;

Gene name

rsbW

Comments [?]

Function	Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
Catalytic activity	RHEA:17989: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] EC 2.7.11.1
	RHEA:46608: ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] EC 2.7.11.1
Similarity	Belongs to the anti-sigma-factor family.

Keywords [?]

Gene Ontology [?]

GO:0004672; Molecular function: protein kinase activity.
GO:0010468; Biological process: regulation of gene expression.

Cross-references [?]

Pfam	PF02518; HATPase_c; 1;
NCBIfam	TIGR01924; rsbW_low_gc; 1;

Additional information [?]