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Annotation rule MF_00638
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General rule information [?]

Accession MF_00638
Dates 17-APR-2003 (Created)
27-OCT-2018 (Last updated, Version 17)
Name Anti_sigma_B
Scope
Bacteria; Bacillales
Template P17904 (RSBW_BACSU)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RSBW
Protein name
RecName: Full=Serine-protein kinase RsbW;
EC=2.7.11.1;
AltName: Full=Anti-sigma-B factor;
AltName: Full=Sigma-B negative effector RsbW;
Gene name
rsbW

Comments [?]

Function Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
Catalytic activity Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
Similarity Belongs to the anti-sigma-factor family.

Keywords [?]

ATP-binding
Kinase
Nucleotide-binding
Serine/threonine-protein kinase
Transferase

Gene Ontology [?]

GO:0004672; Molecular function: protein kinase activity.
GO:0010468; Biological process: regulation of gene expression.

Cross-references [?]

Pfam PF02518; HATPase_c; 1;
TIGRFAMs TIGR01924; rsbW_low_gc; 1;

Additional information [?]

Size range 157-162 amino acids
Related rules MF_00637 (SP2AB)
Fusion None


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