HAMAP rule MF_00664
General rule information
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| Accession | MF_00664 |
| Dates | 28-JUN-2003 (Created)
2-FEB-2024 (Last updated, Version 33) |
| Name | PS_decarb_PSD_A |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q9FDI9 (PSD_RHIME); O28234 (ASD_ARCFU); P0A8K1 (PSD_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00664 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Bacteria> | |
| Identifier | PSD |
| Protein name | RecName: Full=Phosphatidylserine decarboxylase proenzyme; EC=4.1.1.65; Contains: RecName: Full=Phosphatidylserine decarboxylase alpha chain; Contains: RecName: Full=Phosphatidylserine decarboxylase beta chain; |
| Gene name | Name=psd; |
| else case <OC:Archaea> | |
| Identifier | ASD |
| Protein name | RecName: Full=Putative archaetidylserine decarboxylase proenzyme; EC=4.1.1.-; Contains: RecName: Full=Archaetidylserine decarboxylase alpha chain; Contains: RecName: Full=Archaetidylserine decarboxylase beta chain; |
| Gene name | Name=asd; |
| end case | |
Comments
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| case <OC:Bacteria> | |
| FUNCTION | Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). |
| CATALYTIC ACTIVITY | Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2- diacyl-sn-glycero-3-phosphoethanolamine + CO2; Xref=Rhea:RHEA:20828, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57262, ChEBI:CHEBI:64612; EC=4.1.1.65; |
| PATHWAY | Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. |
| else case <OC:Archaea> | |
| FUNCTION | Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer). |
| CATALYTIC ACTIVITY | Reaction=archaetidylserine + H(+) = archaetidylethanolamine + CO2; Xref=Rhea:RHEA:51488, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:71517, ChEBI:CHEBI:134176; |
| end case | |
| COFACTOR | Name=pyruvate; Xref=ChEBI:CHEBI:15361; Note=Binds 1 pyruvoyl group covalently per subunit.; |
| SUBUNIT | Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein. |
| PTM | Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. |
| SIMILARITY | Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily. |
Keywords
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| Cell membrane |
| Decarboxylase |
| Lipid biosynthesis |
| Lipid metabolism |
| Lyase |
| Membrane |
| Phospholipid biosynthesis |
| Phospholipid metabolism |
| Pyruvate |
| Zymogen |
Gene Ontology
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| GO:0005886; Cellular component:plasma membrane | |
| case <OCellular component:Bacteria> | |
| GO:0004609; Molecular function:phosphatidylserine decarboxylase activity | |
| GO:0006646; Biological process:phosphatidylethanolamine biosynthetic process | |
| else case <OCellular component:Archaea> | |
| GO:0008654; Biological process:phospholipid biosynthetic process | |
| end case | |
Cross-references
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Features
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| From: PSD_RHIME (Q9FDI9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacteria> | ||||||||||||
| CHAIN | Nter | 189 | /note="Phosphatidylserine decarboxylase beta chain" | |||||||||
| CHAIN | 190 | Cter | /note="Phosphatidylserine decarboxylase alpha chain" | |||||||||
| else case <OC:Archaea> | ||||||||||||
| CHAIN | Nter | 189 | /note="Archaetidylserine decarboxylase beta chain" | |||||||||
| CHAIN | 190 | Cter | /note="Archaetidylserine decarboxylase alpha chain" | |||||||||
| end case | ||||||||||||
| ACT_SITE | 190 | 190 | /note="Schiff-base intermediate with substrate; via pyruvic acid" | S | ||||||||
| SITE | 189 | 190 | /note="Cleavage (non-hydrolytic); by autocatalysis" | G-S | ||||||||
| MOD_RES | 190 | 190 | /note="Pyruvic acid (Ser); by autocatalysis" | S | ||||||||
Additional information
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| Size range | 195-265 amino acids |
| Related rules |
MF_00662 MF_00663 |
| Fusion | Nter: None Cter: None |
| Comments | Classification of phosphatidylserine decarboxylase into subfamilies was done according to Daiyasu at al.(2005) (PubMed:16243780). |