HAMAP rule MF_00692

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00692
Accession	MF_00692
Dates	28-FEB-2005 (Created) 14-FEB-2025 (Last updated, Version 24)
Name	YdiU_SelO
Scope(s)	Bacteria
Template(s)	Q87VB1; P77649; Q8ZPS5; [ Recover all ]
Triggered by	HAMAP; MF_00692 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SELO
Protein name	RecName: Full=Protein nucleotidyltransferase YdiU; EC=2.7.7.-; AltName: Full=Protein adenylyltransferase YdiU; EC=2.7.7.108; AltName: Full=Protein uridylyltransferase YdiU; EC=2.7.7.-;
Gene name	Name=ydiU; Synonyms=selO;

Comments [?]

FUNCTION	Nucleotidyltransferase involved in the post-translational modification of proteins. It can catalyze the addition of adenosine monophosphate (AMP) or uridine monophosphate (UMP) to a protein, resulting in modifications known as AMPylation and UMPylation.
CATALYTIC ACTIVITY	Reaction=L-seryl-[protein] + ATP = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate; Xref=Rhea:RHEA:58120, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:15073, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:142516; EC=2.7.7.108;
CATALYTIC ACTIVITY	Reaction=L-threonyl-[protein] + ATP = 3-O-(5'-adenylyl)-L-threonyl- [protein] + diphosphate; Xref=Rhea:RHEA:54292, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13847, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:138113; EC=2.7.7.108;
CATALYTIC ACTIVITY	Reaction=L-tyrosyl-[protein] + ATP = O-(5'-adenylyl)-L-tyrosyl- [protein] + diphosphate; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108;
CATALYTIC ACTIVITY	Reaction=L-histidyl-[protein] + UTP = N(tele)-(5'-uridylyl)-L-histidyl- [protein] + diphosphate; Xref=Rhea:RHEA:83891, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:20239, ChEBI:CHEBI:29979, ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:233474;
CATALYTIC ACTIVITY	Reaction=L-seryl-[protein] + UTP = O-(5'-uridylyl)-L-seryl-[protein] + diphosphate; Xref=Rhea:RHEA:64604, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:16635, ChEBI:CHEBI:29999, ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:156051;
CATALYTIC ACTIVITY	Reaction=L-tyrosyl-[protein] + UTP = O-(5'-uridylyl)-L-tyrosyl- [protein] + diphosphate; Xref=Rhea:RHEA:83887, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:20238, ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:46858, ChEBI:CHEBI:90602;
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
SIMILARITY	Belongs to the SELO family.

Keywords [?]

Nucleotidyltransferase

Transferase

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0000287; Molecular function:magnesium ion binding

GO:0030145; Molecular function:manganese ion binding

GO:0016779; Molecular function:nucleotidyltransferase activity

Cross-references [?]

Pfam	PF02696; UPF0061; 1;
NCBIfam	NF040880; adnlytase_SelO; 0-1;

Features [?]

From: SELO_PSESM (Q87VB1)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

252

/note="Proton acceptor"

BINDING