HAMAP rule MF_00692
General rule information
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| Accession | MF_00692 |
| Dates | 29-JUL-2003 (Created)
2-SEP-2024 (Last updated, Version 27) |
| Name | SelO |
| Scope(s) |
Bacteria |
| Template(s) | Q87VB1 (SELO_PSESM); P77649 (SELO_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00692 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SELO |
| Protein name | RecName: Full=Protein adenylyltransferase SelO; EC=2.7.7.108; |
| Gene name | Name=selO; |
Comments
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| FUNCTION | Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). |
| CATALYTIC ACTIVITY | Reaction=L-tyrosyl-[protein] + ATP = O-(5'-adenylyl)-L-tyrosyl- [protein] + diphosphate; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54289; |
| CATALYTIC ACTIVITY | Reaction=L-threonyl-[protein] + ATP = 3-O-(5'-adenylyl)-L-threonyl- [protein] + diphosphate; Xref=Rhea:RHEA:54292, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13847, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:138113; EC=2.7.7.108; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54293; |
| CATALYTIC ACTIVITY | Reaction=L-seryl-[protein] + ATP = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate; Xref=Rhea:RHEA:58120, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:15073, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:142516; EC=2.7.7.108; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58121; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SIMILARITY | Belongs to the SELO family. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0000287; Molecular function:magnesium ion binding |
| GO:0016779; Molecular function:nucleotidyltransferase activity |
Cross-references
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| Pfam | PF02696; UPF0061; 1; |
Features
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| From: SELO_PSESM (Q87VB1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 90 | 93 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-D-G-R | ||||||||
| BINDING | 125 | 126 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D-G | ||||||||
| ACT_SITE | 252 | 252 | /note="Proton acceptor" | D | ||||||||
| BINDING | 253 | 253 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
N | ||||||||
| BINDING | 262 | 262 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 113 | 113 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
| BINDING | 176 | 176 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R | ||||||||
| BINDING | 183 | 183 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R | ||||||||
Additional information
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| Size range | 450-650 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |