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HAMAP rule MF_00692

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General rule information [?]

PURL https://purl.expasy.org/hamap/rule/MF_00692
Accession MF_00692
Dates 29-JUL-2003 (Created)
2-SEP-2024 (Last updated, Version 27)
Name SelO
Scope(s) Bacteria
Template(s) Q87VB1 (SELO_PSESM); P77649 (SELO_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00692 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SELO
Protein name RecName: Full=Protein adenylyltransferase SelO;
                 EC=2.7.7.108;
Gene name Name=selO;

Comments [?]

FUNCTIONCatalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
CATALYTIC ACTIVITY Reaction=L-tyrosyl-[protein] + ATP = O-(5'-adenylyl)-L-tyrosyl- [protein] + diphosphate; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.108; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54289;
CATALYTIC ACTIVITY Reaction=L-threonyl-[protein] + ATP = 3-O-(5'-adenylyl)-L-threonyl- [protein] + diphosphate; Xref=Rhea:RHEA:54292, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13847, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:138113; EC=2.7.7.108; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54293;
CATALYTIC ACTIVITY Reaction=L-seryl-[protein] + ATP = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate; Xref=Rhea:RHEA:58120, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:15073, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:142516; EC=2.7.7.108; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58121;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
SIMILARITYBelongs to the SELO family.

Keywords [?]

ATP-binding
Magnesium
Metal-binding
Nucleotide-binding
Nucleotidyltransferase
Transferase

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0000287; Molecular function:magnesium ion binding
GO:0016779; Molecular function:nucleotidyltransferase activity

Cross-references [?]

Pfam PF02696; UPF0061; 1;

Features [?]

From: SELO_PSESM (Q87VB1)
Key From To Description Tag Condition FTGroup
BINDING 90 93 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 G-D-G-R
BINDING 125 126 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 D-G
ACT_SITE 252 252 /note="Proton acceptor" D
BINDING 253 253 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 N
BINDING 262 262 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 D
BINDING 113 113 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 K
BINDING 176 176 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 R
BINDING 183 183 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 R

Additional information [?]

Size range 450-650 amino acids
Related rules None
Fusion Nter: None Cter: None



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