HAMAP logo

HAMAP rule MF_00698

Send feedback

General rule information [?]

Accession MF_00698
Dates 22-AUG-2003 (Created)
18-NOV-2019 (Last updated, Version 18)
Name Aminopeptidase_S15
Scope(s) Bacteria
Template(s) P22346 (PEPX_LACLC); Q93M42 (PEPX_STRGN); [ Recover all ]
Triggered by HAMAP; MF_00698 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PEPX
Protein name RecName: Full=Xaa-Pro dipeptidyl-peptidase;
AltName: Full=X-Pro dipeptidyl-peptidase;
AltName: Full=X-prolyl-dipeptidyl aminopeptidase;
Gene name Name=pepX;

Comments [?]

FUNCTIONRemoves N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
CATALYTIC ACTIVITY Reaction=Hydrolyzes Xaa-Pro-|- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-|-p-nitroanilide and (sequentially) Tyr-Pro-|-Phe-Pro-|-Gly-Pro-|-Ile.; EC=;
SIMILARITYBelongs to the peptidase S15 family.

Keywords [?]

Gene Ontology [?]

GO:0008239; Molecular function:dipeptidyl-peptidase activity
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF02129; Peptidase_S15; 1;

Features [?]

From: PEPX_LACLC (P22346)
Key From To Description Tag Condition FTGroup
ACT_SITE 348 348 /note="Charge relay system" S
ACT_SITE 468 468 /note="Charge relay system" D
ACT_SITE 498 498 /note="Charge relay system" H

Additional information [?]

Size range 755-813 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)