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HAMAP rule MF_00704

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General rule information [?]

Accession MF_00704
Dates 27-AUG-2003 (Created)
17-FEB-2023 (Last updated, Version 21)
Name Aspartoacylase
Scope(s) Bacteria
Template(s) P45381 (ACY2_HUMAN); [ Recover all ]
Triggered by HAMAP; MF_00704 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ASPA
Protein name RecName: Full=Probable aspartoacylase;

Comments [?]

CATALYTIC ACTIVITY Reaction=H2O + N-acyl-L-aspartate = a carboxylate + L-aspartate; Xref=Rhea:RHEA:10872, ChEBI:CHEBI:15377, ChEBI:CHEBI:29067, ChEBI:CHEBI:29991, ChEBI:CHEBI:58497; EC=;
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
SIMILARITYBelongs to the AspA/AstE family. Aspartoacylase subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0019807; Molecular function:aspartoacylase activity

Cross-references [?]

Pfam PF04952; AstE_AspA; 1;
PIRSF PIRSF018001; Aspartoacylase; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 63 64 /ligand="substrate" N-R
BINDING 14 14 /ligand="Zn(2+)"
H 1
BINDING 17 17 /ligand="Zn(2+)"
E 1
BINDING 106 106 /ligand="Zn(2+)"
H 1
BINDING 56 56 /ligand="substrate" R
BINDING 164 164 /ligand="substrate" E
BINDING 275 275 /ligand="substrate" Y

Additional information [?]

Size range 288-307 amino acids
Related rules None
Fusion Nter: None Cter: None

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