HAMAP rule MF_00704
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00704 |
| Accession | MF_00704 |
| Dates | 28-FEB-2005 (Created)
02-SEP-2024 (Last updated, Version 20) |
| Name | Aspartoacylase |
| Scope(s) |
Bacteria Cyanobacteriota |
| Template(s) | P45381; [ Recover all ] |
| Triggered by |
HAMAP; MF_00704 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ASPA |
| Protein name | RecName: Full=Probable aspartoacylase; EC=3.5.1.15; |
Comments
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| CATALYTIC ACTIVITY | Reaction=an N-acyl-L-aspartate + H2O = a carboxylate + L-aspartate; Xref=Rhea:RHEA:10872, ChEBI:CHEBI:15377, ChEBI:CHEBI:29067, ChEBI:CHEBI:29991, ChEBI:CHEBI:58497; EC=3.5.1.15; |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| SIMILARITY | Belongs to the AspA/AstE family. Aspartoacylase subfamily. |
Keywords
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| Hydrolase | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| GO:0019807; Molecular function:aspartoacylase activity | |
Cross-references
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| Pfam | PF04952; AstE_AspA; 1; |
| PIRSF | PIRSF018001; Aspartoacylase; 1; |
Features
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| From: ASPA_NOSS1 (Q8YQC1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 63 | 64 | /ligand="substrate" | N-R | ||||||||
| BINDING | 14 | 14 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
| BINDING | 17 | 17 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
E | 1 | |||||||
| BINDING | 106 | 106 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
| BINDING | 56 | 56 | /ligand="substrate" | R | ||||||||
| BINDING | 164 | 164 | /ligand="substrate" | E | ||||||||
| BINDING | 275 | 275 | /ligand="substrate" | Y | ||||||||
Additional information
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| Size range | 288-307 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |