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HAMAP rule MF_00706

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General rule information [?]

Accession MF_00706
Dates 1-SEP-2003 (Created)
18-NOV-2019 (Last updated, Version 25)
Name Ecotin
Scope
Bacteria
Template P23827 (ECOT_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ECOT
Protein name
RecName: Full=Ecotin;
Flags: Precursor;
Gene name
eco

Comments [?]

case <OC:Enterobacterales>
Function General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases.
else
Function General inhibitor of family S1 serine proteases.
end case
Subunit Homodimer.
Subcellular location Periplasm.
Similarity Belongs to the protease inhibitor I11 (ecotin) family.

Keywords [?]

case <FT:2>
Disulfide bond
end case
Protease inhibitor
Serine protease inhibitor
Periplasm
Signal

Gene Ontology [?]

GO:0004867; Molecular function: serine-type endopeptidase inhibitor activity.
GO:0042597; Cellular component: periplasmic space.

Cross-references [?]

Pfam PF03974; Ecotin; 1;

Computed features [?]

General Signal; -; 1; trigger=yes;

Features [?]

From: ECOT_ECOLI (P23827)
Key     From     To       Description   Tag   Condition   FTGroup
SITE     104     105       Reactive bond     x-M  
DISULFID     70     107             C-x*-C  

Additional information [?]

Size range 156-183 amino acids
Related rules None
Fusion None


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