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HAMAP rule MF_00711

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General rule information [?]

Accession MF_00711
Dates 19-SEP-2003 (Created)
1-JUN-2023 (Last updated, Version 23)
Name GcvP
Template P33195 (GCSP_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Glycine dehydrogenase (decarboxylating);
AltName: Full=Glycine cleavage system P-protein;
AltName: Full=Glycine decarboxylase;
AltName: Full=Glycine dehydrogenase (aminomethyl-transferring);
Gene name

Comments [?]

Function The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Catalytic activity RHEA:24304: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2
Cofactor pyridoxal 5'-phosphate
Subunit The glycine cleavage system is composed of four proteins: P, T, L and H.
Similarity Belongs to the GcvP family.

Keywords [?]

Gene Ontology [?]

GO:0019464; Biological process: glycine decarboxylation via glycine cleavage system.

Cross-references [?]

Pfam PF02347; GDC-P; 1;
NCBIfam TIGR00461; GcvP; 1;

Features [?]

From: GCSP_ECOLI (P33195)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     708     708       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 932-993 amino acids
Related rules MF_00712 (GCSPA); MF_00713 (GCSPB)
Fusion None