HAMAP rule MF_00711

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00711
Accession	MF_00711
Dates	28-FEB-2005 (Created) 02-SEP-2024 (Last updated, Version 21)
Name	GcvP
Scope(s)	Bacteria
Template(s)	P33195; [ Recover all ]
Triggered by	HAMAP; MF_00711 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GCSP
Protein name	RecName: Full=Glycine dehydrogenase (decarboxylating); EC=1.4.4.2; AltName: Full=Glycine cleavage system P-protein; AltName: Full=Glycine decarboxylase; AltName: Full=Glycine dehydrogenase (aminomethyl-transferring);
Gene name	Name=gcvP;

Comments [?]

FUNCTION	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
CATALYTIC ACTIVITY	Reaction=N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl- [glycine-cleavage complex H protein] + CO2; Xref=Rhea:RHEA:24304, Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099, ChEBI:CHEBI:83143; EC=1.4.4.2;
COFACTOR	Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
SUBUNIT	The glycine cleavage system is composed of four proteins: P, T, L and H.
SIMILARITY	Belongs to the GcvP family.

Keywords [?]

Gene Ontology [?]

GO:0019464; Biological process:glycine decarboxylation via glycine cleavage system

Cross-references [?]

Pfam	PF02347; GDC-P; 1;
NCBIfam	TIGR00461; GcvP; 1;

Features [?]

From: GCSP_ECOLI (P33195)

Key

From

Description

Tag

Condition

FTGroup

MOD_RES

708

/note="N6-(pyridoxal phosphate)lysine"

Additional information [?]