HAMAP rule MF_00711

General rule information [?]

Accession	MF_00711
Dates	19-SEP-2003 (Created) 1-JUN-2023 (Last updated, Version 23)

Name

GcvP

Scope

Bacteria

Template

P33195 (GCSP_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GCSP

Protein name

RecName:		Full=Glycine dehydrogenase (decarboxylating);
		EC 1.4.4.2;
AltName:		Full=Glycine cleavage system P-protein;
AltName:		Full=Glycine decarboxylase;
AltName:		Full=Glycine dehydrogenase (aminomethyl-transferring);

Gene name

gcvP

Comments [?]

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Catalytic activity	RHEA:24304: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 EC 1.4.4.2
Cofactor	pyridoxal 5'-phosphate
Subunit	The glycine cleavage system is composed of four proteins: P, T, L and H.
Similarity	Belongs to the GcvP family.

Keywords [?]

Gene Ontology [?]

GO:0019464; Biological process: glycine decarboxylation via glycine cleavage system.

Cross-references [?]

Pfam	PF02347; GDC-P; 1;
NCBIfam	TIGR00461; GcvP; 1;

Features [?]

From: GCSP_ECOLI (P33195)

Key From To Description Tag Condition FTGroup

MOD_RES 708 708 N6-(pyridoxal phosphate)lysine K

Additional information [?]