HAMAP rule MF_00711
General rule information
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Accession | MF_00711 |
Dates | 19-SEP-2003 (Created) 1-JUN-2023 (Last updated, Version 23) |
Name | GcvP |
Scope | Bacteria |
Template | P33195 (GCSP_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. |
Catalytic activity | RHEA:24304: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2
EC 1.4.4.2 |
Cofactor | pyridoxal 5'-phosphate |
Subunit | The glycine cleavage system is composed of four proteins: P, T, L and H. |
Similarity | Belongs to the GcvP family. |
Keywords
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Gene Ontology
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GO:0019464; Biological process: glycine decarboxylation via glycine cleavage system.
Cross-references
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Features
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From: GCSP_ECOLI (P33195) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOD_RES | 708 | 708 | N6-(pyridoxal phosphate)lysine | K |
Additional information
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