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HAMAP rule MF_00711

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General rule information [?]

Accession MF_00711
Dates 19-SEP-2003 (Created)
14-SEP-2023 (Last updated, Version 24)
Name GcvP
Scope(s) Bacteria
Template(s) P33195 (GCSP_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00711 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GCSP
Protein name RecName: Full=Glycine dehydrogenase (decarboxylating);
AltName: Full=Glycine cleavage system P-protein;
AltName: Full=Glycine decarboxylase;
AltName: Full=Glycine dehydrogenase (aminomethyl-transferring);
Gene name Name=gcvP;

Comments [?]

FUNCTIONThe glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
CATALYTIC ACTIVITY Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]- L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304, Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099, ChEBI:CHEBI:83143; EC=;
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
SUBUNITThe glycine cleavage system is composed of four proteins: P, T, L and H.
SIMILARITYBelongs to the GcvP family.

Keywords [?]

Gene Ontology [?]

GO:0019464; Biological process:glycine decarboxylation via glycine cleavage system

Cross-references [?]

Pfam PF02347; GDC-P; 1;
NCBIfam TIGR00461; GcvP; 1;

Features [?]

From: GCSP_ECOLI (P33195)
Key From To Description Tag Condition FTGroup
MOD_RES 708 708 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 932-993 amino acids
Related rules MF_00712
Fusion Nter: None Cter: None

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