HAMAP rule MF_00712
General rule information
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Accession | MF_00712 |
Dates | 1-OCT-2003 (Created)
14-SEP-2023 (Last updated, Version 20) |
Name | GcvPA |
Scope(s) |
Bacteria Archaea |
Template(s) | P33195 (GCSP_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00712 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GCSPA |
Protein name | RecName: Full=Probable glycine dehydrogenase (decarboxylating) subunit 1; EC=1.4.4.2; AltName: Full=Glycine cleavage system P-protein subunit 1; AltName: Full=Glycine decarboxylase subunit 1; AltName: Full=Glycine dehydrogenase (aminomethyl-transferring) subunit 1; |
Gene name | Name=gcvPA; |
Comments
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FUNCTION | The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. |
CATALYTIC ACTIVITY | Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]- L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304, Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099, ChEBI:CHEBI:83143; EC=1.4.4.2; |
SUBUNIT | The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. |
SIMILARITY | Belongs to the GcvP family. N-terminal subunit subfamily. |
Keywords
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Gene Ontology
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GO:0019464; Biological process:glycine decarboxylation via glycine cleavage system |
Cross-references
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Pfam | PF02347; GDC-P; 1; |
Features
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Additional information
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Size range | 433-471 amino acids |
Related rules |
MF_00711 |
Fusion | Nter: None Cter: None |