HAMAP rule MF_00712

General rule information [?]

Accession	MF_00712
Dates	1-OCT-2003 (Created) 2-SEP-2024 (Last updated, Version 21)
Name	GcvPA
Scope(s)	Bacteria Archaea
Template(s)	P33195 (GCSP_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00712 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GCSPA
Protein name	RecName: Full=Probable glycine dehydrogenase (decarboxylating) subunit 1; EC=1.4.4.2; AltName: Full=Glycine cleavage system P-protein subunit 1; AltName: Full=Glycine decarboxylase subunit 1; AltName: Full=Glycine dehydrogenase (aminomethyl-transferring) subunit 1;
Gene name	Name=gcvPA;

Comments [?]

FUNCTION	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
CATALYTIC ACTIVITY	Reaction=N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl- [glycine-cleavage complex H protein] + CO2; Xref=Rhea:RHEA:24304, Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099, ChEBI:CHEBI:83143; EC=1.4.4.2;
SUBUNIT	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.
SIMILARITY	Belongs to the GcvP family. N-terminal subunit subfamily.

Keywords [?]

Gene Ontology [?]

GO:0019464; Biological process:glycine decarboxylation via glycine cleavage system

Cross-references [?]

Pfam	PF02347; GDC-P; 1;

Features [?]

Additional information [?]