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HAMAP rule MF_00712

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General rule information [?]

Accession MF_00712
Dates 1-OCT-2003 (Created)
3-FEB-2022 (Last updated, Version 19)
Name GcvPA
Template P33195 (GCSP_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Probable glycine dehydrogenase (decarboxylating) subunit 1;
AltName: Full=Glycine cleavage system P-protein subunit 1;
AltName: Full=Glycine decarboxylase subunit 1;
AltName: Full=Glycine dehydrogenase (aminomethyl-transferring) subunit 1;
Gene name

Comments [?]

Function The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Catalytic activity RHEA:24304: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2
Subunit The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.
Similarity Belongs to the GcvP family. N-terminal subunit subfamily.

Keywords [?]

Gene Ontology [?]

GO:0019464; Biological process: glycine decarboxylation via glycine cleavage system.

Cross-references [?]

Pfam PF02347; GDC-P; 1;

Additional information [?]

Size range 433-471 amino acids
Related rules MF_00711 (GCSP)
Fusion None