HAMAP rule MF_00712

General rule information [?]

Accession	MF_00712
Dates	1-OCT-2003 (Created) 3-FEB-2022 (Last updated, Version 19)

Name

GcvPA

Scope

Bacteria

Archaea

Template

P33195 (GCSP_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GCSPA

Protein name

RecName:		Full=Probable glycine dehydrogenase (decarboxylating) subunit 1;
		EC 1.4.4.2;
AltName:		Full=Glycine cleavage system P-protein subunit 1;
AltName:		Full=Glycine decarboxylase subunit 1;
AltName:		Full=Glycine dehydrogenase (aminomethyl-transferring) subunit 1;

Gene name

gcvPA

Comments [?]

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Catalytic activity	RHEA:24304: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 EC 1.4.4.2
Subunit	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.
Similarity	Belongs to the GcvP family. N-terminal subunit subfamily.

Keywords [?]

Gene Ontology [?]

GO:0019464; Biological process: glycine decarboxylation via glycine cleavage system.

Cross-references [?]

Pfam	PF02347; GDC-P; 1;

Additional information [?]