HAMAP rule MF_00712
General rule information
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Accession |
MF_00712 |
Dates |
1-OCT-2003 (Created) 3-FEB-2022 (Last updated, Version 19) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Probable glycine dehydrogenase (decarboxylating) subunit 1;
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EC 1.4.4.2;
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AltName:
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Full=Glycine cleavage system P-protein subunit 1;
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AltName:
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Full=Glycine decarboxylase subunit 1;
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AltName:
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Full=Glycine dehydrogenase (aminomethyl-transferring) subunit 1;
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Function |
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. |
Catalytic activity |
RHEA:24304: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2
EC 1.4.4.2
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Subunit |
The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. |
Similarity |
Belongs to the GcvP family. N-terminal subunit subfamily. |
GO:0019464; Biological process: glycine decarboxylation via glycine cleavage system.
Additional information
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Size range |
433-471 amino acids |
Related rules |
MF_00711 (GCSP) |
Fusion |
None |