HAMAP rule MF_00732

General rule information [?]

Accession	MF_00732
Dates	21-NOV-2003 (Created) 7-FEB-2023 (Last updated, Version 29)

Name

HTH_MntR

Scope

Bacteria; Bacilli

Template

P54512 (MNTR_BACSU)

Triggered by

HAMAP; MF_00732 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MNTR

Protein name

RecName:		Full=HTH-type transcriptional regulator MntR;
AltName:		Full=Manganese transport regulator;

Gene name

mntR

Comments [?]

Function	Central regulator of manganese homeostasis.
Activity regulation	DNA binding is strongly activated by Mn(2+).
Subunit	Homodimer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the DtxR/MntR family.

Keywords [?]

Activator
Cytoplasm
DNA-binding
Manganese
Metal-binding
Repressor
Transcription
Transcription regulation

Gene Ontology [?]

GO:0030145; Molecular function: manganese ion binding.
GO:0003700; Molecular function: DNA-binding transcription factor activity.
GO:0030026; Biological process: intracellular manganese ion homeostasis.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF02742; Fe_dep_repr_C; 1;
	PF01325; Fe_dep_repress; 1;
PROSITE	PS50944; HTH_DTXR; 1; trigger=PRU00296;

Features [?]

From: MNTR_BACSU (P54512)

Key From To Description Tag Condition FTGroup

BINDING 8 8 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 D

BINDING 11 11 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 E

BINDING 77 77 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 H

BINDING 99 99 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 E

BINDING 99 99 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 E

BINDING 102 102 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 E

BINDING 102 102 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 E

BINDING 103 103 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 H

Additional information [?]

Size range	130-170 amino acids
Related rules	None
Fusion	None

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