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HAMAP rule MF_00735

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General rule information [?]

Accession MF_00735
Dates 24-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 21)
Name Methyltr_PrmA
Scope(s) Bacteria
Template(s) P0A8T1 (PRMA_ECOLI); Q84BQ9 (PRMA_THET8); [ Recover all ]
Triggered by HAMAP; MF_00735 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PRMA
Protein name RecName: Full=Ribosomal protein L11 methyltransferase;
                 Short=L11 Mtase;
Gene name Name=prmA;

Comments [?]

FUNCTIONMethylates ribosomal protein L11.
CATALYTIC ACTIVITY Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961;
SIMILARITYBelongs to the methyltransferase superfamily. PrmA family.

Keywords [?]

Gene Ontology [?]

GO:0008276; Molecular function:protein methyltransferase activity
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PIRSF PIRSF000401; RPL11_MTase; 0-1;
NCBIfam TIGR00406; PrmA; 1;

Features [?]

From: PRMA_THET8 (Q84BQ9)
Key From To Description Tag Condition FTGroup
BINDING 107 107 /ligand="S-adenosyl-L-methionine"
T 1
BINDING 128 128 /ligand="S-adenosyl-L-methionine"
G 1
BINDING 149 149 /ligand="S-adenosyl-L-methionine"
D 1
BINDING 191 191 /ligand="S-adenosyl-L-methionine"
N 1

Additional information [?]

Size range 220-400 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments See: MEDLINE=20450294; PubMed=10997488; Bujnicki J.M.; "Sequence, structural, and evolutionary analysis of prokaryotic ribosomal protein L11 methyltransferases."; Acta Microbiol. Pol. 49:19-29(2000).

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