HAMAP rule MF_00735

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00735
Accession	MF_00735
Dates	28-FEB-2005 (Created) 02-SEP-2024 (Last updated, Version 20)
Name	Methyltr_PrmA
Scope(s)	Bacteria
Template(s)	P0A8T1; Q84BQ9; [ Recover all ]
Triggered by	HAMAP; MF_00735 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PRMA
Protein name	RecName: Full=Ribosomal protein L11 methyltransferase; Short=L11 Mtase; EC=2.1.1.-;
Gene name	Name=prmA;

Comments [?]

FUNCTION	Methylates ribosomal protein L11.
CATALYTIC ACTIVITY	Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L- homocysteine + 3 H(+); Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961;
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the methyltransferase superfamily. PrmA family.

Keywords [?]

Gene Ontology [?]

GO:0008276; Molecular function:protein methyltransferase activity

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PIRSF	PIRSF000401; RPL11_MTase; 0-1;
NCBIfam	TIGR00406; PrmA; 1;

Features [?]

From: PRMA_THET8 (Q84BQ9)

Key

From

Description

Tag

Condition

FTGroup

BINDING

107

/ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"

BINDING

128

/ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"

BINDING

149

/ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"

BINDING

191

/ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"

Additional information [?]

Size range	220-400 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	See: MEDLINE=20450294; PubMed=10997488; Bujnicki J.M.; "Sequence, structural, and evolutionary analysis of prokaryotic ribosomal protein L11 methyltransferases."; Acta Microbiol. Pol. 49:19-29(2000).