HAMAP rule MF_00741

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00741
Accession	MF_00741
Dates	28-FEB-2005 (Created) 02-SEP-2024 (Last updated, Version 31)
Name	AIRS
Scope(s)	Bacteria Archaea
Template(s)	P08178; [ Recover all ]
Triggered by	HAMAP; MF_00741 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PUR5
Protein name	RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase; EC=6.3.3.1; AltName: Full=AIR synthase; AltName: Full=AIRS; AltName: Full=Phosphoribosyl-aminoimidazole synthetase;
Gene name	Name=purM;

Comments [?]

CATALYTIC ACTIVITY	Reaction=2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+); Xref=Rhea:RHEA:23032, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:137981, ChEBI:CHEBI:147287, ChEBI:CHEBI:456216; EC=6.3.3.1;
PATHWAY	Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide: step 2/2.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the AIR synthase family.

Keywords [?]

Gene Ontology [?]

GO:0004641; Molecular function:phosphoribosylformylglycinamidine cyclo-ligase activity

GO:0006189; Biological process:'de novo' IMP biosynthetic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]