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Annotation rule MF_00741
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General rule information [?]

Accession MF_00741
Dates 27-NOV-2003 (Created)
17-APR-2020 (Last updated, Version 30)
Name AIRS
Scope
Bacteria
Archaea
Template P08178 (PUR5_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PUR5
Protein name
RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase;
EC 6.3.3.1;
AltName: Full=AIR synthase;
AltName: Full=AIRS;
AltName: Full=Phosphoribosyl-aminoimidazole synthetase;
Gene name
purM

Comments [?]

Catalytic activity RHEA:23032: 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate
EC 6.3.3.1
Pathway Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.
Subcellular location Cytoplasm.
Similarity Belongs to the AIR synthase family.

Keywords [?]

ATP-binding
Cytoplasm
Ligase
Nucleotide-binding
Purine biosynthesis

Gene Ontology [?]

GO:0004641; Molecular function: phosphoribosylformylglycinamidine cyclo-ligase activity.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00586; AIRS; 1;
PF02769; AIRS_C; 1;
TIGRFAMs TIGR00878; PurM; 1;
TIGR01847; Bacteriocin_sig; 1;

Additional information [?]

Size range 290-430 amino acids
Related rules None
Fusion None


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