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HAMAP rule MF_00741

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General rule information [?]

Accession MF_00741
Dates 27-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 31)
Scope(s) Bacteria
Template(s) P08178 (PUR5_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00741 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PUR5
Protein name RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase;
AltName: Full=AIR synthase;
AltName: Full=AIRS;
AltName: Full=Phosphoribosyl-aminoimidazole synthetase;
Gene name Name=purM;

Comments [?]

CATALYTIC ACTIVITY Reaction=2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate; Xref=Rhea:RHEA:23032, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:137981, ChEBI:CHEBI:147287, ChEBI:CHEBI:456216; EC=;
PATHWAYPurine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide: step 2/2.
SIMILARITYBelongs to the AIR synthase family.

Keywords [?]

Gene Ontology [?]

GO:0004641; Molecular function:phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0006189; Biological process:'de novo' IMP biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00586; AIRS; 1;
Pfam PF02769; AIRS_C; 1;
NCBIfam TIGR00878; PurM; 1;
NCBIfam TIGR01847; Bacteriocin_sig; 1;

Features [?]

Additional information [?]

Size range 290-430 amino acids
Related rules None
Fusion Nter: None Cter: None

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