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HAMAP rule MF_00742

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General rule information [?]

Accession MF_00742
Dates 1-DEC-2003 (Created)
1-JUN-2023 (Last updated, Version 30)
Name Formyl_CoA_transfer
Scope(s) Bacteria
Template(s) P69902 (FCTA_ECOLI); O06644 (FCTA_OXAFO); [ Recover all ]
Triggered by HAMAP; MF_00742 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FCTA
Protein name RecName: Full=Formyl-CoA:oxalate CoA-transferase;
                 Short=FCOCT;
                 EC=2.8.3.16;
AltName: Full=Formyl-coenzyme A transferase;
                 Short=Formyl-CoA transferase;
Gene name Name=frc;

Comments [?]

FUNCTIONInvolved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl- CoA to oxalate.
CATALYTIC ACTIVITY Reaction=formyl-CoA + oxalate = formate + oxalyl-CoA; Xref=Rhea:RHEA:16545, ChEBI:CHEBI:15740, ChEBI:CHEBI:30623, ChEBI:CHEBI:57376, ChEBI:CHEBI:57388; EC=2.8.3.16;
SUBUNITHomodimer.
PATHWAYMetabolic intermediate degradation; oxalate degradation; CO(2) and formate from oxalate: step 1/2.
SIMILARITYBelongs to the CoA-transferase III family. Frc subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008410; Molecular function:CoA-transferase activity

Cross-references [?]

Pfam PF02515; CoA_transf_3; 1;
NCBIfam TIGR03253; oxalate_frc; 1;

Features [?]

From: FCTA_OXAFO (O06644)
Key From To Description Tag Condition FTGroup
BINDING 15 18 /ligand="CoA"
/ligand_id="ChEBI:CHEBI:57287"
H-x-Q-A
BINDING 72 75 /ligand="CoA"
/ligand_id="ChEBI:CHEBI:57287"
L-x-[MT]-K
BINDING 96 98 /ligand="CoA"
/ligand_id="ChEBI:CHEBI:57287"
N-x-[GAH]
BINDING 137 140 /ligand="CoA"
/ligand_id="ChEBI:CHEBI:57287"
K-x-Y-E
BINDING 260 262 /ligand="substrate" G-G-Q
ACT_SITE 169 169 /note="Nucleophile" D
BINDING 38 38 /ligand="CoA"
/ligand_id="ChEBI:CHEBI:57287"
R
BINDING 104 104 /ligand="CoA"
/ligand_id="ChEBI:CHEBI:57287"
[RH]
From: FCTA_ECOLI (P69902)
Key From To Description Tag Condition FTGroup
BINDING 17 18 /ligand="CoA"
/ligand_id="ChEBI:CHEBI:57287"
Q-S
BINDING 273 275 /ligand="CoA"
/ligand_id="ChEBI:CHEBI:57287"
Q-E-x

Additional information [?]

Size range 409-428 amino acids
Related rules None
Fusion Nter: None Cter: None



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