HAMAP rule MF_00742
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00742 |
| Accession | MF_00742 |
| Dates | 1-DEC-2003 (Created)
2-SEP-2024 (Last updated, Version 32) |
| Name | Formyl_CoA_transfer |
| Scope(s) |
Bacteria |
| Template(s) | P69902 (FCTA_ECOLI); O06644 (FCTA_OXAFO); [ Recover all ] |
| Triggered by |
HAMAP; MF_00742 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FCTA |
| Protein name | RecName: Full=Formyl-CoA:oxalate CoA-transferase; Short=FCOCT; EC=2.8.3.16; AltName: Full=Formyl-coenzyme A transferase; Short=Formyl-CoA transferase; |
| Gene name | Name=frc; |
Comments
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| FUNCTION | Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl- CoA to oxalate. |
| CATALYTIC ACTIVITY | Reaction=formyl-CoA + oxalate = oxalyl-CoA + formate; Xref=Rhea:RHEA:16545, ChEBI:CHEBI:15740, ChEBI:CHEBI:30623, ChEBI:CHEBI:57376, ChEBI:CHEBI:57388; EC=2.8.3.16; |
| SUBUNIT | Homodimer. |
| PATHWAY | Metabolic intermediate degradation; oxalate degradation; CO(2) and formate from oxalate: step 1/2. |
| SIMILARITY | Belongs to the CoA-transferase III family. Frc subfamily. |
Keywords
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Gene Ontology
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| GO:0008410; Molecular function:CoA-transferase activity |
| GO:0033611; Biological process:oxalate catabolic process |
Cross-references
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Features
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| From: FCTA_OXAFO (O06644) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 15 | 18 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
H-x-Q-A | ||||||||
| BINDING | 72 | 75 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
L-x-[MT]-K | ||||||||
| BINDING | 96 | 98 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
N-x-[GAH] | ||||||||
| BINDING | 137 | 140 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
K-x-Y-E | ||||||||
| BINDING | 260 | 262 | /ligand="substrate" | G-G-Q | ||||||||
| ACT_SITE | 169 | 169 | /note="Nucleophile" | D | ||||||||
| BINDING | 38 | 38 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
R | ||||||||
| BINDING | 104 | 104 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
[RH] | ||||||||
| From: FCTA_ECOLI (P69902) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 17 | 18 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
Q-S | ||||||||
| BINDING | 273 | 275 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
Q-E-x | ||||||||
Additional information
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| Size range | 409-428 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |