HAMAP rule MF_00744
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00744 |
| Accession | MF_00744 |
| Dates | 10-DEC-2003 (Created)
26-JAN-2023 (Last updated, Version 23) |
| Name | MetJ |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P0A8U6 (METJ_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00744 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | METJ |
| Protein name | RecName: Full=Met repressor; AltName: Full=Met regulon regulatory protein MetJ; |
| Gene name | Name=metJ; |
Comments
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| FUNCTION | This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| DOMAIN | Does not bind DNA by a helix-turn-helix motif. |
| SIMILARITY | Belongs to the MetJ family. |
Keywords
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| Cytoplasm |
| Amino-acid biosynthesis |
| Transcription |
| Transcription regulation |
| Repressor |
| Methionine biosynthesis |
| DNA-binding |
Gene Ontology
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| GO:0045892; Biological process:negative regulation of DNA-templated transcription |
| GO:0009086; Biological process:methionine biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF01340; MetJ; 1; |
Features
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Additional information
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| Size range | 104-106 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |