HAMAP rule MF_00769
General rule information
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| Accession | MF_00769 |
| Dates | 10-APR-2004 (Created)
8-OCT-2024 (Last updated, Version 19) |
| Name | 2PGK |
| Scope(s) |
Archaea Methanobacteriati |
| Template(s) | Q49156 (PGK2_METFV); [ Recover all ] |
| Triggered by |
HAMAP; MF_00769 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PGK2 |
| Protein name | RecName: Full=2-phosphoglycerate kinase; Short=2PGK; EC=2.7.2.16; |
| Gene name | Name=pgk2; |
Comments
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| FUNCTION | Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3- diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3- bisphosphoglycerate, a thermoprotectant. |
| CATALYTIC ACTIVITY | Reaction=(2R)-2-phosphoglycerate + ATP = (2R)-2,3-bisphosphoglycerate + ADP + H(+); Xref=Rhea:RHEA:42408, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58248, ChEBI:CHEBI:58289, ChEBI:CHEBI:456216; EC=2.7.2.16; |
| COFACTOR | Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; |
| PATHWAY | Thermoadapter biosynthesis; cyclic 2,3-diphosphoglycerate biosynthesis; cyclic 2,3-diphosphoglycerate from 2-phospho-D-glycerate: step 1/2. |
| SIMILARITY | Belongs to the 2-phosphoglycerate kinase family. |
Keywords
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| Transferase | |
| Kinase | |
| case <Feature:PS51161> | |
| Nucleotide-binding | |
| ATP-binding | |
| end case | |
Gene Ontology
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| GO:0016774; Molecular function:phosphotransferase activity, carboxyl group as acceptor |
Cross-references
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Features
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Additional information
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| Size range | 301-327 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |