HAMAP rule MF_00784
General rule information
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| Accession | MF_00784 |
| Dates | 18-MAY-2004 (Created)
13-JAN-2023 (Last updated, Version 20) |
| Name | AgrB |
| Scope(s) |
Bacteria Bacillota |
| Template(s) | P0C1P7 (AGRB_STAAU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00784 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | AGRB |
| case <OC:Staphylococcus> | |
| Protein name | RecName: Full=Accessory gene regulator protein B; EC=3.4.-.-; |
| Gene name | Name=agrB; |
| end case | |
| case not <OC:Staphylococcus> | |
| Protein name | RecName: Full=Putative AgrB-like protein; EC=3.4.-.-; |
| end case | |
Comments
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| case <OC:Staphylococcus> | |
| FUNCTION | Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP. |
| end case | |
| case not <OC:Staphylococcus> | |
| FUNCTION | May be involved in the proteolytic processing of a quorum sensing system signal molecule precursor. |
| end case | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the AgrB family. |
Keywords
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| Cell membrane | |
| Membrane | |
| Hydrolase | |
| Protease | |
| Quorum sensing | |
| Transmembrane | |
| case <OC:Staphylococcus> | |
| Virulence | |
| end case | |
| Transmembrane helix | |
Gene Ontology
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| GO:0008233; Molecular function:peptidase activity |
| GO:0009372; Biological process:quorum sensing |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF04647; AgrB; 1; |
| General | Transmembrane; -; 3-5; |
Features
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Additional information
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| Size range | 187-242 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |