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HAMAP rule MF_00809

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General rule information [?]

Accession MF_00809
Dates 6-APR-2005 (Created)
19-NOV-2022 (Last updated, Version 22)
Name ADP_glucokinase
Templates Q9V2Z6 (GLKA_PYRFU); O58328 (GLKA_PYRHO); Q7M537 (GLKA_THELN); Q5JE39 (GLKA_THEKO): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=ADP-dependent glucose/glucosamine kinase;
EC 2.7.1.-;
AltName: Full=ADP-dependent glucokinase;
AltName: Full=Glucosamine kinase;
Short=GlcN kinase;
Gene name

Comments [?]

Function Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate.
Catalytic activity RHEA:11460: ADP + D-glucose = AMP + D-glucose 6-phosphate + H(+)
RHEA:62084: ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate + H(+)
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
Pathway Carbohydrate degradation; glycolysis.
Subcellular location Cytoplasm.
Similarity Belongs to the ADP-dependent glucokinase family.

Keywords [?]

Gene Ontology [?]

GO:0004340; Molecular function: glucokinase activity.
GO:0006096; Biological process: glycolytic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF04587; ADP_PFK_GK; 1;
PROSITE PS51255; ADPK; 1; trigger=PRU00584;
PIRSF PIRSF015883; ADP-Pfk_glckin; 0-1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     342     343       /ligand="ADP" /ligand_id="ChEBI:CHEBI:456216     H-T  
BINDING     112     113       /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167     G-Q  
ACT_SITE     440     440       Proton acceptor     D  
BINDING     266     266       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     E  
BINDING     295     295       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     E  
BINDING     440     440       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D  
BINDING     34     34       /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167     D  
BINDING     88     88       /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167     E  
BINDING     176     176       /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167     H  
BINDING     292     292       /ligand="ADP" /ligand_id="ChEBI:CHEBI:456216     N  
BINDING     429     429       /ligand="ADP" /ligand_id="ChEBI:CHEBI:456216     V  
BINDING     439     439       /ligand="ADP" /ligand_id="ChEBI:CHEBI:456216     G  
BINDING     440     440       /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167     D  

Additional information [?]

Size range 450-470 amino acids
Related rules MF_00561 (K6PF)
Fusion None