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HAMAP rule MF_00809
General rule information
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| Accession | MF_00809 |
| Dates | 6-APR-2005 (Created)
19-NOV-2022 (Last updated, Version 22) |
| Name | ADP_glucokinase |
| Scope(s) |
Archaea |
| Template(s) | Q9V2Z6 (GLKA_PYRFU); O58328 (GLKA_PYRHO); Q7M537 (GLKA_THELN); Q5JE39 (GLKA_THEKO); [ Recover all ] |
| Triggered by |
HAMAP; MF_00809 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GLKA |
| Protein name | RecName: Full=ADP-dependent glucose/glucosamine kinase; EC=2.7.1.-; EC=2.7.1.147; AltName: Full=ADP-dependent glucokinase; Short=ADP-GK; Short=ADPGK; AltName: Full=Glucosamine kinase; Short=GlcN kinase; |
| Gene name | Name=glkA; |
Comments
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| FUNCTION | Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate. |
| CATALYTIC ACTIVITY | Reaction=ADP + D-glucose = AMP + D-glucose 6-phosphate + H(+); Xref=Rhea:RHEA:11460, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378, ChEBI:CHEBI:61548, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.1.147; |
| CATALYTIC ACTIVITY | Reaction=ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate + H(+); Xref=Rhea:RHEA:62084, ChEBI:CHEBI:15378, ChEBI:CHEBI:58723, ChEBI:CHEBI:58725, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
| PATHWAY | Carbohydrate degradation; glycolysis. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the ADP-dependent glucokinase family. |
Keywords
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| Carbohydrate metabolism |
| Cytoplasm |
| Glucose metabolism |
| Glycolysis |
| Kinase |
| Magnesium |
| Metal-binding |
| Transferase |
Gene Ontology
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| GO:0004340; Molecular function:glucokinase activity |
| GO:0006096; Biological process:glycolytic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF04587; ADP_PFK_GK; 1; |
| PROSITE | PS51255; ADPK; 1; |
| PIRSF | PIRSF015883; ADP-Pfk_glckin; 0-1; |
Features
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| From: GLKA_PYRFU (Q9V2Z6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 342 | 343 | /ligand="ADP" /ligand_id="ChEBI:CHEBI:456216" |
H-T | ||||||||
| BINDING | 112 | 113 | /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167" |
G-Q | ||||||||
| ACT_SITE | 440 | 440 | /note="Proton acceptor" | D | ||||||||
| BINDING | 266 | 266 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | ||||||||
| BINDING | 295 | 295 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | ||||||||
| BINDING | 440 | 440 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 34 | 34 | /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167" |
D | ||||||||
| BINDING | 88 | 88 | /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167" |
E | ||||||||
| BINDING | 176 | 176 | /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167" |
H | ||||||||
| BINDING | 292 | 292 | /ligand="ADP" /ligand_id="ChEBI:CHEBI:456216" |
N | ||||||||
| BINDING | 429 | 429 | /ligand="ADP" /ligand_id="ChEBI:CHEBI:456216" |
V | ||||||||
| BINDING | 439 | 439 | /ligand="ADP" /ligand_id="ChEBI:CHEBI:456216" |
G | ||||||||
| BINDING | 440 | 440 | /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167" |
D | ||||||||
Additional information
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| Size range | 450-470 amino acids |
| Related rules |
MF_00561 |
| Fusion | Nter: None Cter: None |