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Annotation rule MF_00809
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General rule information [?]

Accession MF_00809
Dates 6-APR-2005 (Created)
21-NOV-2019 (Last updated, Version 19)
Name ADP_glucokinase
Scope
Archaea
Templates Q9V2Z6 (GLKA_PYRFU); O58328 (GLKA_PYRHO); Q7M537 (GLKA_THELN); Q5JE39 (GLKA_THEKO): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GLKA
Protein name
RecName: Full=ADP-dependent glucose/glucosamine kinase;
EC 2.7.1.-;
EC 2.7.1.147;
AltName: Full=ADP-dependent glucokinase;
Short=ADP-GK;
Short=ADPGK;
AltName: Full=Glucosamine kinase;
Short=GlcN kinase;
Gene name
glkA

Comments [?]

Function Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate.
Catalytic activity RHEA:11460: ADP + D-glucose = AMP + D-glucose 6-phosphate + H(+)
EC 2.7.1.147
RHEA:62084: ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate + H(+)
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
Pathway Carbohydrate degradation; glycolysis.
Subcellular location Cytoplasm.
Similarity Belongs to the ADP-dependent glucokinase family.

Keywords [?]

Carbohydrate metabolism
Cytoplasm
Glucose metabolism
Glycolysis
Kinase
Magnesium
Metal-binding
Transferase

Gene Ontology [?]

GO:0004340; Molecular function: glucokinase activity.
GO:0006096; Biological process: glycolytic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF04587; ADP_PFK_GK; 1;
PROSITE PS51255; ADPK; 1; trigger=PRU00584;
PIRSF PIRSF015883; ADP-Pfk_glckin; 0-1;

Features [?]

From: GLKA_PYRFU (Q9V2Z6)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     342     343       ADP     H-T  
REGION     112     113       Glucose binding     G-Q  
ACT_SITE     440     440       Proton acceptor     D  
METAL     266     266       Magnesium     E  
METAL     295     295       Magnesium     E  
METAL     440     440       Magnesium     D  
BINDING     34     34       Glucose     D  
BINDING     88     88       Glucose     E  
BINDING     176     176       Glucose     H  
BINDING     292     292       ADP     N  
BINDING     429     429       ADP; via amide nitrogen and carbonyl oxygen     V  
BINDING     439     439       ADP; via amide nitrogen     G  
BINDING     440     440       Glucose     D  

Additional information [?]

Size range 450-470 amino acids
Related rules MF_00561 (K6PF)
Fusion None


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