HAMAP rule MF_00809

General rule information [?]

Accession	MF_00809
Dates	6-APR-2005 (Created) 19-NOV-2022 (Last updated, Version 22)

Name	ADP_glucokinase

Scope

Archaea

Templates

Q9V2Z6 (GLKA_PYRFU); O58328 (GLKA_PYRHO); Q7M537 (GLKA_THELN); Q5JE39 (GLKA_THEKO): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GLKA

Protein name

RecName:		Full=ADP-dependent glucose/glucosamine kinase;
		EC 2.7.1.-;
		EC 2.7.1.147;
AltName:		Full=ADP-dependent glucokinase;
		Short=ADP-GK;
		Short=ADPGK;
AltName:		Full=Glucosamine kinase;
		Short=GlcN kinase;

Gene name

glkA

Comments [?]

Function	Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate.
Catalytic activity	RHEA:11460: ADP + D-glucose = AMP + D-glucose 6-phosphate + H(+) EC 2.7.1.147
	RHEA:62084: ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate + H(+)
Cofactor	Mg(2+) Note: Binds 1 Mg(2+) ion per subunit.
Pathway	Carbohydrate degradation; glycolysis.
Subcellular location	Cytoplasm.
Similarity	Belongs to the ADP-dependent glucokinase family.

Keywords [?]

Gene Ontology [?]

GO:0004340; Molecular function: glucokinase activity.
GO:0006096; Biological process: glycolytic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Features [?]

From: GLKA_PYRFU (Q9V2Z6)

Key From To Description Tag Condition FTGroup

BINDING 342 343 /ligand="ADP" /ligand_id="ChEBI:CHEBI:456216 H-T

BINDING 112 113 /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167 G-Q

ACT_SITE 440 440 Proton acceptor D

BINDING 266 266 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 E

BINDING 295 295 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 E

BINDING 440 440 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D

BINDING 34 34 /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167 D

BINDING 88 88 /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167 E

BINDING 176 176 /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167 H

BINDING 292 292 /ligand="ADP" /ligand_id="ChEBI:CHEBI:456216 N

BINDING 429 429 /ligand="ADP" /ligand_id="ChEBI:CHEBI:456216 V

BINDING 439 439 /ligand="ADP" /ligand_id="ChEBI:CHEBI:456216 G

BINDING 440 440 /ligand="D-glucose" /ligand_id="ChEBI:CHEBI:4167 D

Additional information [?]