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HAMAP rule MF_00825

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General rule information [?]

Accession MF_00825
Dates 21-JUN-2006 (Created)
26-JAN-2023 (Last updated, Version 21)
Name 3_HAO
Templates Q1LCS4 (3HAO_CUPMC); Q83V26 (3HAO_PSEFL): [Recover all]
case <OC:Bacteria>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=3-hydroxyanthranilate 3,4-dioxygenase;
AltName: Full=3-hydroxyanthranilate oxygenase;
AltName: Full=3-hydroxyanthranilic acid dioxygenase;
Gene name

Comments [?]

Function Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
Catalytic activity RHEA:17953: 3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde
case <FTGroup:1> and <FTGroup:2>
Cofactor Fe(2+)
Note: Binds 2 Fe(2+) ions per subunit.
else case <FTGroup:1> or <FTGroup:2>
Cofactor Fe(2+)
end case
Pathway Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.
case <OC:Pseudomonadota>
Subunit Homodimer.
end case
Similarity Belongs to the 3-HAO family.

Keywords [?]

case <FTGroup:1> or <FTGroup:2>
end case

Gene Ontology [?]

GO:0000334; Molecular function: 3-hydroxyanthranilate 3,4-dioxygenase activity.
GO:0008198; Molecular function: ferrous iron binding.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0019805; Biological process: quinolinate biosynthetic process.
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
GO:0043420; Biological process: anthranilate metabolic process.

Cross-references [?]

Pfam PF06052; 3-HAO; 1;
TIGRFAMs TIGR03037; Anthran_nbaC; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     51     51       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" /ligand_note="catalytic     H   1
BINDING     57     57       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" /ligand_note="catalytic     E   1
BINDING     95     95       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" /ligand_note="catalytic     H   1
BINDING     125     125       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     C   2
BINDING     128     128       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     C   2
BINDING     162     162       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     C   2
BINDING     165     165       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     C   2
BINDING     47     47       /ligand="O2" /ligand_id="ChEBI:CHEBI:15379     R  
BINDING     57     57       /ligand="substrate     E  
BINDING     99     99       /ligand="substrate     R  
BINDING     110     110       /ligand="substrate     E  

Additional information [?]

Size range 174-189 amino acids
Related rules None
Fusion None