HAMAP rule MF_00837
General rule information
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| Accession | MF_00837 |
| Dates | 26-OCT-2011 (Created) 26-JAN-2023 (Last updated, Version 11) |
| Name | PagP_transferase |
| Scope | Bacteria; Pseudomonadota |
| Templates | P37001 (PAGP_ECOLI); Q8XBR9 (PAGP_ECO57); Q8ZR06 (PAGP_SALTY); Q7WFT9 (PAGP_BORBR): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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case <OC:Escherichia>
| Protein name |
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else
| Protein name |
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end case
| Protein name |
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| Gene name |
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Comments
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case <OC:Escherichia>
| Function | Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. |
| Catalytic activity | RHEA:46864: 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
EC 2.3.1.251 |
| RHEA:46872: 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB
EC 2.3.1.251 |
|
| RHEA:46868: 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli)
EC 2.3.1.251 |
else
| Function | Transfers a fatty acid residue from the sn-1 position of a phospholipid to the N-linked hydroxyfatty acid chain on the proximal unit of lipid A or its precursors. |
| Catalytic activity | RHEA:74275: a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A = a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A
EC 2.3.1.251 |
| RHEA:74283: a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB
EC 2.3.1.251 |
|
| RHEA:74279: a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA = a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB
EC 2.3.1.251 |
end case
| Subunit | Homodimer. |
case <Feature:PS51257>
| Subcellular location | Cell outer membrane; Lipid-anchor. |
end case
case not <Feature:PS51257>
| Subcellular location | Cell outer membrane. |
end case
| Similarity | Belongs to the lipid A palmitoyltransferase family. |
Keywords
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Gene Ontology
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case <OC:Escherichia>
GO:0016416; Molecular function: O-palmitoyltransferase activity.
else
GO:0016746; Molecular function: acyltransferase activity.
end case
GO:0009245; Biological process: lipid A biosynthetic process.
Cross-references
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Computed features
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| General | Signal; -; 1; trigger=yes; |
Features
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| From: PAGP_ECOLI (P37001) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 58 | 58 | H | |||||||||
| ACT_SITE | 101 | 101 | D | |||||||||
| ACT_SITE | 102 | 102 | S | |||||||||
| SITE | 67 | 67 | Role in lipopolysaccharide recognition | K | ||||||||
| SITE | 172 | 172 | Role in the phospholipid gating | Y | ||||||||
Additional information
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| Size range | 160-240 amino acids |
| Related rules | None |
| Fusion | None |