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HAMAP rule MF_00837

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General rule information [?]

Accession MF_00837
Dates 26-OCT-2011 (Created)
26-JAN-2023 (Last updated, Version 11)
Name PagP_transferase
Scope
Bacteria; Pseudomonadota
Templates P37001 (PAGP_ECOLI); Q8XBR9 (PAGP_ECO57); Q8ZR06 (PAGP_SALTY); Q7WFT9 (PAGP_BORBR): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PAGP
case <OC:Escherichia>
Protein name
RecName: Full=Lipid A palmitoyltransferase PagP;
EC 2.3.1.251;
else
Protein name
RecName: Full=Lipid A acyltransferase PagP;
EC 2.3.1.251;
end case
Protein name
AltName: Full=Lipid A acylation protein;
Flags: Precursor;
Gene name
pagP

Comments [?]

case <OC:Escherichia>
Function Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors.
Catalytic activity RHEA:46864: 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
EC 2.3.1.251
RHEA:46872: 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB
EC 2.3.1.251
RHEA:46868: 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli)
EC 2.3.1.251
else
Function Transfers a fatty acid residue from the sn-1 position of a phospholipid to the N-linked hydroxyfatty acid chain on the proximal unit of lipid A or its precursors.
Catalytic activity RHEA:74275: a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A = a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A
EC 2.3.1.251
RHEA:74283: a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB
EC 2.3.1.251
RHEA:74279: a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA = a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB
EC 2.3.1.251
end case
Subunit Homodimer.
case <Feature:PS51257>
Subcellular location Cell outer membrane; Lipid-anchor.
end case
case not <Feature:PS51257>
Subcellular location Cell outer membrane.
end case
Similarity Belongs to the lipid A palmitoyltransferase family.

Keywords [?]


Gene Ontology [?]

case <OC:Escherichia>
GO:0016416; Molecular function: O-palmitoyltransferase activity.
else
GO:0016746; Molecular function: acyltransferase activity.
end case
GO:0009245; Biological process: lipid A biosynthetic process.

Cross-references [?]

PROSITE PS51257; PROKAR_LIPOPROTEIN; 0-1; trigger=PRU00303;
Pfam PF07017; PagP; 1;

Computed features [?]

General Signal; -; 1; trigger=yes;

Features [?]

From: PAGP_ECOLI (P37001)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     58     58             H  
ACT_SITE     101     101             D  
ACT_SITE     102     102             S  
SITE     67     67       Role in lipopolysaccharide recognition     K  
SITE     172     172       Role in the phospholipid gating     Y  

Additional information [?]

Size range 160-240 amino acids
Related rules None
Fusion None