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Annotation rule MF_00837
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General rule information [?]

Accession MF_00837
Dates 26-OCT-2011 (Created)
18-NOV-2019 (Last updated, Version 9)
Name PagP_transferase
Scope
Bacteria; Proteobacteria
Templates P37001 (PAGP_ECOLI); Q8XBR9 (PAGP_ECO57); Q8ZR06 (PAGP_SALTY); Q7WFT9 (PAGP_BORBR): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PAGP
Protein name
RecName: Full=Lipid A palmitoyltransferase PagP;
EC 2.3.1.251;
AltName: Full=Lipid A acylation protein;
Flags: Precursor;
Gene name
pagP

Comments [?]

Function Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors.
Catalytic activity RHEA:46864: 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
EC 2.3.1.251
RHEA:46872: 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB
EC 2.3.1.251
RHEA:46868: 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB
EC 2.3.1.251
Subunit Homodimer.
case <Feature:PS51257>
Subcellular location Cell outer membrane; Lipid-anchor.
end case
case not <Feature:PS51257>
Subcellular location Cell outer membrane.
end case
Similarity Belongs to the lipid A palmitoyltransferase family.

Keywords [?]


Gene Ontology [?]

GO:0016416; Molecular function: O-palmitoyltransferase activity.
GO:0009245; Biological process: lipid A biosynthetic process.

Cross-references [?]

PROSITE PS51257; PROKAR_LIPOPROTEIN; 0-1; trigger=PRU00303;
Pfam PF07017; PagP; 1;

Computed features [?]

General Signal; -; 1; trigger=yes;

Features [?]

From: PAGP_ECOLI (P37001)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     58     58             H  
ACT_SITE     101     101             D  
ACT_SITE     102     102             S  
SITE     67     67       Role in lipopolysaccharide recognition     K  
SITE     172     172       Role in the phospholipid gating     Y  

Additional information [?]

Size range 160-240 amino acids
Related rules None
Fusion None