HAMAP rule MF_00839

General rule information [?]

Accession	MF_00839
Dates	25-APR-2016 (Created) 26-JAN-2023 (Last updated, Version 5)

Name

HPF

Scope

Bacteria

Templates

A2RIX0 (HPF_LACLM); A0A0H3GEZ8 (HPF_LISM4); P28368 (HPF_BACSU); Q2FIN9 (HPF_STAA3); P19954 (PRSP1_SPIOL): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HPF

Protein name

RecName:		Full=Ribosome hibernation promoting factor;
		Short=HPF;

Gene name

hpf

Comments [?]

Function	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Subunit	Interacts with 100S ribosomes.
Subcellular location	Cytoplasm.
Similarity	Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.

Keywords [?]

Gene Ontology [?]

GO:0006417; Biological process: regulation of translation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Additional information [?]

Size range	178-254 amino acids
Related rules	None
Fusion	None
Comments	This family does not include the short paralogs (YfiA and short HPF) found in some Pseudomonadota as they have a slightly altered function. It encompasses a chloroplast-targeted protein but does not annotate it.