HAMAP rule MF_00848
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00848 |
| Accession | MF_00848 |
| Dates | 02-DEC-2019 (Created)
03-SEP-2024 (Last updated, Version 9) |
| Name | Uup |
| Scope(s) |
Bacteria |
| Template(s) | P43672; [ Recover all ] |
| Triggered by |
HAMAP; MF_00848 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | UUP |
| Protein name | RecName: Full=ATP-binding protein Uup; EC=3.6.1.-; |
| Gene name | Name=uup; |
Comments
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| FUNCTION | Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity. |
| CATALYTIC ACTIVITY | Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; |
| SUBCELLULAR LOCATION | Cytoplasm. Note=Associates with ribosomes. |
| SIMILARITY | Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily. |
Keywords
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| ATP-binding | |
| case <Feature:coiled> | |
| Coiled coil | |
| end case | |
| Cytoplasm | |
| DNA-binding | |
| DNA repair | |
| DNA damage | |
| Hydrolase | |
| Nucleotide-binding | |
| Repeat | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0016887; Molecular function:ATP hydrolysis activity |
| GO:0005737; Cellular component:cytoplasm |
| GO:0003677; Molecular function:DNA binding |
| GO:0043022; Molecular function:ribosome binding |
Cross-references
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| PROSITE | PS00211; ABC_TRANSPORTER_1; 1-2; |
| PROSITE | PS50893; ABC_TRANSPORTER_2; 2; |
| Pfam | PF00005; ABC_tran; 2; |
| Pfam | PF16326; ABC_tran_CTD; 0-1; |
| Pfam | PF12848; ABC_tran_Xtn; 0-1; |
| General | Coiled_coil; -; 0-unlimited; |
Features
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| From: UUP_ECOLI (P43672) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | 1 | 253 | /note="ABC transporter 1" | |||||||||
| DOMAIN | 320 | 546 | /note="ABC transporter 2" | |||||||||
| BINDING | 36 | 43 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" /ligand_label="1" |
G-x-N-G-[ACESTV]-G-[KQ]-[ST] | ||||||||
| BINDING | 352 | 359 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" /ligand_label="2" |
G-x-[NS]-[GA]-[ACISTV]-G-K-[ST] | ||||||||
Additional information
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| Size range | 582-686 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |