HAMAP rule MF_00848

General rule information [?]

Accession	MF_00848
Dates	2-DEC-2019 (Created) 19-NOV-2022 (Last updated, Version 7)

Name

Uup

Scope

Bacteria

Template

P43672 (UUP_ECOLI)

Triggered by

HAMAP; MF_00848 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

UUP

Protein name

RecName:		Full=ATP-binding protein Uup;
		EC 3.6.1.-;

Gene name

uup

Comments [?]

Function	Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.
Catalytic activity	RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
Subcellular location	Cytoplasm. Note=Associates with ribosomes.
Similarity	Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.

Keywords [?]

ATP-binding

case <Feature:coiled>

Coiled coil

end case

Cytoplasm
DNA-binding
DNA repair
DNA damage
Hydrolase
Nucleotide-binding
Repeat

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0016887; Molecular function: ATP hydrolysis activity.
GO:0005737; Cellular component: cytoplasm.
GO:0003677; Molecular function: DNA binding.
GO:0043022; Molecular function: ribosome binding.

Cross-references [?]

PROSITE	PS00211; ABC_TRANSPORTER_1; 1-2;
	PS50893; ABC_TRANSPORTER_2; 2;
Pfam	PF00005; ABC_tran; 2;
	PF16326; ABC_tran_CTD; 0-1;
	PF12848; ABC_tran_Xtn; 0-1;

Computed features [?]

General

Coiled_coil; -; 0-unlimited;

Features [?]

From: UUP_ECOLI (P43672)

Key From To Description Tag Condition FTGroup

DOMAIN 1 253 ABC transporter 1

DOMAIN 320 546 ABC transporter 2

BINDING 36 43 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" /ligand_label="1 G-x-N-G-[ACESTV]-G-[KQ]-[ST]

BINDING 352 359 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" /ligand_label="2 G-x-[NS]-[GA]-[ACISTV]-G-K-[ST]

Additional information [?]

Size range	582-686 amino acids
Related rules	None
Fusion	None

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