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HAMAP rule MF_00861
General rule information
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| Accession | MF_00861 |
| Dates | 19-FEB-2021 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Name | EutB |
| Scope(s) |
Bacteria Archaea Halobacteria |
| Template(s) | P0AEJ7 (EUTB_ECO57); P19264 (EUTB_SALTY); [ Recover all ] |
| Triggered by |
HAMAP; MF_00861 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | EUTB |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=Ethanolamine ammonia-lyase large subunit; Short=EAL large subunit; EC=4.3.1.7; |
| else case <OC:Archaea> | |
| Protein name | RecName: Full=Putative ethanolamine ammonia-lyase large subunit; Short=EAL large subunit; EC=4.3.1.7; |
| end case | |
| Gene name | Name=eutB; |
Comments
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| case <OC:Bacteria> | |
| FUNCTION | Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12. |
| else case <OC:Archaea> | |
| FUNCTION | May catalyze the deamination of various vicinal amino- alcohols to oxo compounds. Would allow this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=ethanolamine = acetaldehyde + NH4(+); Xref=Rhea:RHEA:15313, ChEBI:CHEBI:15343, ChEBI:CHEBI:28938, ChEBI:CHEBI:57603; EC=4.3.1.7; |
| COFACTOR | adenosylcob(III)alamin; Xref=CHEBI:18408; Note=Binds between the large and small subunits. |
| PATHWAY | Amine and polyamine degradation; ethanolamine degradation. |
| SUBUNIT | The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards. |
| case <OC:Bacteria> | |
| SUBCELLULAR LOCATION | Bacterial microcompartment. |
| end case | |
| SIMILARITY | Belongs to the EutB family. |
Keywords
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| Cobalt | |
| Cobalamin | |
| Lyase | |
| case <OC:Bacteria> | |
| Bacterial microcompartment | |
| end case | |
Gene Ontology
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| GO:0008851; Molecular function:ethanolamine ammonia-lyase activity | |
| GO:0009350; Cellular component:ethanolamine ammonia-lyase complex | |
| GO:0046336; Biological process:ethanolamine catabolic process | |
| GO:0031419; Molecular function:cobalamin binding | |
| case <OCellular component:Bacteria> | |
| GO:0031471; Cellular component:ethanolamine degradation polyhedral organelle | |
| end case | |
Cross-references
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| Pfam | PF06751; EutB; 1; |
| PIRSF | PIRSF018788; EutB; 0-1; |
Features
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| From: EUTB_ECOLI (P0AEJ6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 160 | 162 | /ligand="substrate" | R-x-Q | ||||||||
| BINDING | 193 | 193 | /ligand="substrate" | N | ||||||||
| BINDING | 194 | 194 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
P | ||||||||
| BINDING | 246 | 246 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
Q | ||||||||
| BINDING | 287 | 287 | /ligand="substrate" | E | ||||||||
| BINDING | 295 | 295 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
S | ||||||||
| BINDING | 362 | 362 | /ligand="substrate" | D | ||||||||
| BINDING | 401 | 401 | /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408" |
M | ||||||||
Additional information
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| Size range | 409-527 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Both large and small subunits are found in Archaeal Halobacteria. |