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Annotation rule MF_00861
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General rule information [?]

Accession MF_00861
Dates 19-FEB-2021 (Created)
26-FEB-2021 (Last updated, Version 3)
Name EutB
Scope
Bacteria
Archaea; Halobacteria
Templates P0AEJ7 (EUTB_ECO57); P19264 (EUTB_SALTY): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
EUTB
case <OC:Bacteria>
Protein name
RecName: Full=Ethanolamine ammonia-lyase large subunit;
Short=EAL large subunit;
EC 4.3.1.7;
else case <OC:Archaea>
Protein name
RecName: Full=Putative ethanolamine ammonia-lyase large subunit;
Short=EAL large subunit;
EC 4.3.1.7;
end case
Gene name
eutB

Comments [?]

case <OC:Bacteria>
Function Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
else case <OC:Archaea>
Function May catalyze the deamination of various vicinal amino-alcohols to oxo compounds. Would allow this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
end case
Catalytic activity RHEA:15313: ethanolamine = acetaldehyde + NH4(+)
EC 4.3.1.7
Cofactor adenosylcob(III)alamin; Xref=CHEBI:18408;
Note: Binds between the large and small subunits
Pathway Amine and polyamine degradation; ethanolamine degradation.
Subunit The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.
case <OC:Bacteria>
Subcellular location Bacterial microcompartment.
end case
Similarity Belongs to the EutB family.

Keywords [?]

case <OC:Bacteria>
end case

Gene Ontology [?]

GO:0008851; Molecular function: ethanolamine ammonia-lyase activity.
GO:0009350; Cellular component: ethanolamine ammonia-lyase complex.
GO:0046336; Biological process: ethanolamine catabolic process.
GO:0031419; Molecular function: cobalamin binding.
case <OC:Bacteria>
GO:0031471; Cellular component: ethanolamine degradation polyhedral organelle.
end case

Cross-references [?]

Pfam PF06751; EutB; 1;
PIRSF PIRSF018788; EutB; 0-1;

Features [?]

From: EUTB_ECOLI (P0AEJ6)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     160     162       Substrate binding     R-x-Q  
BINDING     193     193       Substrate     N  
BINDING     194     194       Adenosylcob(III)alamin; via carbonyl oxygen     P  
BINDING     246     246       Adenosylcob(III)alamin     Q  
BINDING     287     287       Substrate     E  
BINDING     295     295       Adenosylcob(III)alamin     S  
BINDING     362     362       Substrate     D  
BINDING     401     401       Adenosylcob(III)alamin; via carbonyl oxygen     M  

Additional information [?]

Size range 409-527 amino acids
Related rules None
Fusion None
Comments Both large and small subunits are found in Archaeal Halobacteria.