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HAMAP rule MF_00861

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General rule information [?]

Accession MF_00861
Dates 19-FEB-2021 (Created)
19-NOV-2022 (Last updated, Version 6)
Name EutB
Scope(s) Bacteria
Template(s) P0AEJ7 (EUTB_ECO57); P19264 (EUTB_SALTY); [ Recover all ]
Triggered by HAMAP; MF_00861 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier EUTB
case <OC:Bacteria>
Protein name RecName: Full=Ethanolamine ammonia-lyase large subunit;
                 Short=EAL large subunit;
else case <OC:Archaea>
Protein name RecName: Full=Putative ethanolamine ammonia-lyase large subunit;
                 Short=EAL large subunit;
end case
Gene name Name=eutB;

Comments [?]

case <OC:Bacteria>
FUNCTIONCatalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
else case <OC:Archaea>
FUNCTIONMay catalyze the deamination of various vicinal amino- alcohols to oxo compounds. Would allow this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
end case
CATALYTIC ACTIVITY Reaction=ethanolamine = acetaldehyde + NH4(+); Xref=Rhea:RHEA:15313, ChEBI:CHEBI:15343, ChEBI:CHEBI:28938, ChEBI:CHEBI:57603; EC=;
COFACTORadenosylcob(III)alamin; Xref=CHEBI:18408; Note=Binds between the large and small subunits.
PATHWAYAmine and polyamine degradation; ethanolamine degradation.
SUBUNITThe basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.
case <OC:Bacteria>
SUBCELLULAR LOCATIONBacterial microcompartment.
end case
SIMILARITYBelongs to the EutB family.

Keywords [?]

case <OC:Bacteria>
Bacterial microcompartment
end case

Gene Ontology [?]

GO:0008851; Molecular function:ethanolamine ammonia-lyase activity
GO:0009350; Cellular component:ethanolamine ammonia-lyase complex
GO:0046336; Biological process:ethanolamine catabolic process
GO:0031419; Molecular function:cobalamin binding
case <OCellular component:Bacteria>
GO:0031471; Cellular component:ethanolamine degradation polyhedral organelle
end case

Cross-references [?]

Pfam PF06751; EutB; 1;
PIRSF PIRSF018788; EutB; 0-1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 160 162 /ligand="substrate" R-x-Q
BINDING 193 193 /ligand="substrate" N
BINDING 194 194 /ligand="adenosylcob(III)alamin"
BINDING 246 246 /ligand="adenosylcob(III)alamin"
BINDING 287 287 /ligand="substrate" E
BINDING 295 295 /ligand="adenosylcob(III)alamin"
BINDING 362 362 /ligand="substrate" D
BINDING 401 401 /ligand="adenosylcob(III)alamin"

Additional information [?]

Size range 409-527 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Both large and small subunits are found in Archaeal Halobacteria.

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