HAMAP rule MF_00907
General rule information
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Accession | MF_00907 |
Dates | 29-SEP-2011 (Created)
1-JUN-2023 (Last updated, Version 6) |
Name | Thioesterase_EntH |
Scope(s) |
Bacteria Enterobacterales |
Template(s) | P0A8Y8 (ENTH_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00907 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | ENTH |
Protein name | RecName: Full=Proofreading thioesterase EntH; EC=3.1.2.-; AltName: Full=Enterobactin synthase component H; |
Gene name | Name=entH; |
Comments
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FUNCTION | Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules. |
PATHWAY | Siderophore biosynthesis; enterobactin biosynthesis. |
SUBUNIT | Homotetramer. Dimer of dimers. Interacts specifically with the aryl carrier protein (ArCP) domain of EntB. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the thioesterase PaaI family. |
Keywords
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Gene Ontology
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GO:0016790; Molecular function:thiolester hydrolase activity |
GO:0009239; Biological process:enterobactin biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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From: ENTH_ECOLI (P0A8Y8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 63 | 63 | /note="Nucleophile or proton acceptor" | E |
Additional information
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Size range | 137-139 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |