HAMAP rule MF_00907

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00907
Accession	MF_00907
Dates	29-SEP-2011 (Created) 01-JUN-2023 (Last updated, Version 7)
Name	Thioesterase_EntH
Scope(s)	Bacteria Enterobacterales
Template(s)	P0A8Y8; [ Recover all ]
Triggered by	HAMAP; MF_00907 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ENTH
Protein name	RecName: Full=Proofreading thioesterase EntH; EC=3.1.2.-; AltName: Full=Enterobactin synthase component H;
Gene name	Name=entH;

Comments [?]

FUNCTION	Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules.
PATHWAY	Siderophore biosynthesis; enterobactin biosynthesis.
SUBUNIT	Homotetramer. Dimer of dimers. Interacts specifically with the aryl carrier protein (ArCP) domain of EntB.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the thioesterase PaaI family.

Keywords [?]

Gene Ontology [?]

GO:0016790; Molecular function:thiolester hydrolase activity

GO:0009239; Biological process:enterobactin biosynthetic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam	PF03061; 4HBT; 1;
NCBIfam	TIGR00369; Unchar_dom_1; 1;

Features [?]

From: ENTH_ECOLI (P0A8Y8)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

/note="Nucleophile or proton acceptor"

Additional information [?]