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HAMAP rule MF_00907

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General rule information [?]

Accession MF_00907
Dates 29-SEP-2011 (Created)
1-JUN-2023 (Last updated, Version 6)
Name Thioesterase_EntH
Bacteria; Enterobacterales
Template P0A8Y8 (ENTH_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Proofreading thioesterase EntH;
EC 3.1.2.-;
AltName: Full=Enterobactin synthase component H;
Gene name

Comments [?]

Function Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules.
Pathway Siderophore biosynthesis; enterobactin biosynthesis.
Subunit Homotetramer. Dimer of dimers. Interacts specifically with the aryl carrier protein (ArCP) domain of EntB.
Subcellular location Cytoplasm.
Similarity Belongs to the thioesterase PaaI family.

Keywords [?]

Gene Ontology [?]

GO:0016790; Molecular function: thiolester hydrolase activity.
GO:0009239; Biological process: enterobactin biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF03061; 4HBT; 1;
NCBIfam TIGR00369; Unchar_dom_1; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     63     63       Nucleophile or proton acceptor     E  

Additional information [?]

Size range 137-139 amino acids
Related rules None
Fusion None