HAMAP rule MF_00907

General rule information [?]

Accession	MF_00907
Dates	29-SEP-2011 (Created) 1-JUN-2023 (Last updated, Version 6)

Name	Thioesterase_EntH

Scope

Bacteria; Enterobacterales

Template

P0A8Y8 (ENTH_ECOLI)

Triggered by

HAMAP; MF_00907 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ENTH

Protein name

RecName:		Full=Proofreading thioesterase EntH;
		EC 3.1.2.-;
AltName:		Full=Enterobactin synthase component H;

Gene name

entH

Comments [?]

Function	Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules.
Pathway	Siderophore biosynthesis; enterobactin biosynthesis.
Subunit	Homotetramer. Dimer of dimers. Interacts specifically with the aryl carrier protein (ArCP) domain of EntB.
Subcellular location	Cytoplasm.
Similarity	Belongs to the thioesterase PaaI family.

Keywords [?]

Cytoplasm
Hydrolase

Gene Ontology [?]

GO:0016790; Molecular function: thiolester hydrolase activity.
GO:0009239; Biological process: enterobactin biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF03061; 4HBT; 1;
NCBIfam	TIGR00369; Unchar_dom_1; 1;

Features [?]

From: ENTH_ECOLI (P0A8Y8)

Key From To Description Tag Condition FTGroup

ACT_SITE 63 63 Nucleophile or proton acceptor E

Additional information [?]

Size range	137-139 amino acids
Related rules	None
Fusion	None

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