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HAMAP rule MF_00907

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General rule information [?]

Accession MF_00907
Dates 29-SEP-2011 (Created)
1-JUN-2023 (Last updated, Version 6)
Name Thioesterase_EntH
Scope(s) Bacteria
Template(s) P0A8Y8 (ENTH_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00907 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ENTH
Protein name RecName: Full=Proofreading thioesterase EntH;
AltName: Full=Enterobactin synthase component H;
Gene name Name=entH;

Comments [?]

FUNCTIONRequired for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules.
PATHWAYSiderophore biosynthesis; enterobactin biosynthesis.
SUBUNITHomotetramer. Dimer of dimers. Interacts specifically with the aryl carrier protein (ArCP) domain of EntB.
SIMILARITYBelongs to the thioesterase PaaI family.

Keywords [?]

Gene Ontology [?]

GO:0016790; Molecular function:thiolester hydrolase activity
GO:0009239; Biological process:enterobactin biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF03061; 4HBT; 1;
NCBIfam TIGR00369; Unchar_dom_1; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 63 63 /note="Nucleophile or proton acceptor" E

Additional information [?]

Size range 137-139 amino acids
Related rules None
Fusion Nter: None Cter: None

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