HAMAP rule MF_00917

General rule information [?]

Accession	MF_00917
Dates	8-FEB-2012 (Created) 1-JUN-2023 (Last updated, Version 12)

Name

QueE

Scope

Bacteria

Archaea

Templates

O31677 (QUEE_BACSU); A0A0H3KB22 (QUEE_BURM1): [Recover all]

Triggered by

HAMAP; MF_00917 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

QUEE

case <OC:Bacteria>

Protein name

RecName:		Full=7-carboxy-7-deazaguanine synthase;
		Short=CDG synthase;
		EC 4.3.99.3;
AltName:		Full=Queuosine biosynthesis protein QueE;

else case <OC:Archaea>

Protein name

RecName:		Full=7-carboxy-7-deazaguanine synthase;
		Short=CDG synthase;
		EC 4.3.99.3;
AltName:		Full=Archaeosine biosynthesis protein QueE;

end case

Gene name

queE

Comments [?]

Function	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
Catalytic activity	RHEA:27974: 6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+) EC 4.3.99.3
Cofactor	[4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
	S-adenosyl-L-methionine Note: Binds 1 S-adenosyl-L-methionine per subunit.
	Mg(2+)
Pathway	Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.
Subunit	Homodimer.
Similarity	Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.

Keywords [?]

4Fe-4S
Iron
Iron-sulfur
Lyase
Magnesium
Metal-binding

case <OC:Bacteria>

Queuosine biosynthesis

end case

S-adenosyl-L-methionine

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0016840; Molecular function: carbon-nitrogen lyase activity.
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:1904047; Molecular function: S-adenosyl-L-methionine binding.

case <OC:Bacteria>

GO:0008616; Biological process: queuosine biosynthetic process.

end case

Cross-references [?]

Pfam	PF04055; Radical_SAM; 1;
NCBIfam	TIGR04508; queE_Cx14CxxC; 1;
	TIGR03365; Bsubt_queE; 1;
	TIGR04322; rSAM_QueE_Ecoli; 1;
	TIGR03963; rSAM_QueE_Clost; 1;
PIRSF	PIRSF000370; QueE; 1;

Features [?]

From: QUEE_BURM1 (A0A0H3KB22)

Key From To Description Tag Condition FTGroup

BINDING 12 14 /ligand="substrate x-x-G

BINDING 48 50 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [FYW]-x-D

BINDING (Optional) 133 135 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 S-x-K

BINDING (Optional) 173 176 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 Q-x-x-D

BINDING 31 31 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet C

BINDING 46 46 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet C

BINDING 49 49 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet C

BINDING (Optional) 51 51 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 [TS]

BINDING 27 27 /ligand="substrate R

BINDING 90 90 /ligand="substrate [TS]

BINDING 92 92 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 G

BINDING (Optional) Cter Cter /ligand="substrate P

Additional information [?]

Size range	180-290 amino acids
Related rules	None
Fusion	None

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