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HAMAP rule MF_00930

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General rule information [?]

Accession MF_00930
Dates 7-JAN-2013 (Created)
1-JUN-2023 (Last updated, Version 6)
Name GreB
Scope(s) Bacteria
Template(s) P30128 (GREB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00930 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GREB
Protein name RecName: Full=Transcription elongation factor GreB;
AltName: Full=Transcript cleavage factor GreB;
Gene name Name=greB;

Comments [?]

FUNCTIONNecessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.
SIMILARITYBelongs to the GreA/GreB family. GreB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0032784; Biological process:regulation of DNA-templated transcription elongation

Cross-references [?]

PROSITE PS00829; GREAB_1; 1;
PROSITE PS00830; GREAB_2; 1;
Pfam PF01272; GreA_GreB; 1;
Pfam PF03449; GreA_GreB_N; 1;
NCBIfam TIGR01461; greB; 1;
PIRSF PIRSF006092; GreA_GreB; 1;
General Coiled_coil; -; 0-unlimited;

Features [?]

Additional information [?]

Size range 138-240 amino acids
Related rules MF_00105
Fusion Nter: None Cter: None

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