HAMAP rule MF_00930
General rule information
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| Accession | MF_00930 |
| Dates | 7-JAN-2013 (Created)
1-JUN-2023 (Last updated, Version 6) |
| Name | GreB |
| Scope(s) |
Bacteria |
| Template(s) | P30128 (GREB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00930 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GREB |
| Protein name | RecName: Full=Transcription elongation factor GreB; AltName: Full=Transcript cleavage factor GreB; |
| Gene name | Name=greB; |
Comments
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| FUNCTION | Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. |
| SIMILARITY | Belongs to the GreA/GreB family. GreB subfamily. |
Keywords
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Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0032784; Biological process:regulation of DNA-templated transcription elongation |
Cross-references
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| PROSITE | PS00829; GREAB_1; 1; |
| PROSITE | PS00830; GREAB_2; 1; |
| Pfam | PF01272; GreA_GreB; 1; |
| Pfam | PF03449; GreA_GreB_N; 1; |
| NCBIfam | TIGR01461; greB; 1; |
| PIRSF | PIRSF006092; GreA_GreB; 1; |
| General | Coiled_coil; -; 0-unlimited; |
Features
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Additional information
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| Size range | 138-240 amino acids |
| Related rules |
MF_00105 |
| Fusion | Nter: None Cter: None |