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Annotation rule MF_00930
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General rule information [?]

Accession MF_00930
Dates 7-JAN-2013 (Created)
19-NOV-2019 (Last updated, Version 4)
Name GreB
Scope
Bacteria
Template P30128 (GREB_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GREB
Protein name
RecName: Full=Transcription elongation factor GreB;
AltName: Full=Transcript cleavage factor GreB;
Gene name
greB

Comments [?]

Function Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.
Similarity Belongs to the GreA/GreB family. GreB subfamily.

Keywords [?]

DNA-binding
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0032784; Biological process: regulation of DNA-templated transcription, elongation.

Cross-references [?]

PROSITE PS00829; GREAB_1; 1;
PS00830; GREAB_2; 1;
Pfam PF01272; GreA_GreB; 1;
PF03449; GreA_GreB_N; 1;
TIGRFAMs TIGR01461; greB; 1;
PIRSF PIRSF006092; GreA_GreB; 1;

Computed features [?]

General Coiled_coil; -; 0-unlimited; trigger=yes;

Additional information [?]

Size range 138-240 amino acids
Related rules MF_00105 (GREA)
Fusion None


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