HAMAP rule MF_00937
General rule information
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| Accession | MF_00937 |
| Dates | 21-JAN-2013 (Created)
10-OCT-2023 (Last updated, Version 14) |
| Name | ParC_type2 |
| Scope(s) |
Bacteria Bacillota Mollicutes |
| Template(s) | P72525 (PARC_STRPN); P0AFI2 (PARC_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00937 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PARC |
| Protein name | RecName: Full=DNA topoisomerase 4 subunit A; EC=5.6.2.2; AltName: Full=Topoisomerase IV subunit A; |
| Gene name | Name=parC; |
Comments
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| FUNCTION | Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. |
| CATALYTIC ACTIVITY | Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2; |
| SUBUNIT | Heterotetramer composed of ParC and ParE. |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein. |
| SIMILARITY | Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. |
Keywords
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Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| GO:0007059; Biological process:chromosome segregation |
| GO:0006265; Biological process:DNA topological change |
| GO:0019897; Cellular component:extrinsic component of plasma membrane |
Cross-references
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| Pfam | PF03989; DNA_gyraseA_C; 3-5; |
| Pfam | PF00521; DNA_topoisoIV; 1; |
| NCBIfam | TIGR01061; parC_Gpos; 1; |
| PROSITE | PS52040; TOPO_IIA; 1; |
Features
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| From: PARC_STRPN (P72525) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 118 | 118 | /note="O-(5'-phospho-DNA)-tyrosine intermediate" | Y | ||||||||
| SITE | 38 | 38 | /note="Interaction with DNA" | K | ||||||||
| SITE | 74 | 74 | /note="Interaction with DNA" | H | ||||||||
| SITE | 76 | 76 | /note="Interaction with DNA" | H | ||||||||
| SITE | 87 | 87 | /note="Interaction with DNA" | R | ||||||||
| SITE | 93 | 93 | /note="Interaction with DNA" | K | ||||||||
| SITE | 117 | 117 | /note="Transition state stabilizer" | R | ||||||||
Additional information
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| Size range | 780-880 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | See MF_00936 for ParC type 1 subfamily. |