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HAMAP rule MF_00937

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General rule information [?]

Accession MF_00937
Dates 21-JAN-2013 (Created)
10-OCT-2023 (Last updated, Version 14)
Name ParC_type2
Scope(s) Bacteria
Template(s) P72525 (PARC_STRPN); P0AFI2 (PARC_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00937 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PARC
Protein name RecName: Full=DNA topoisomerase 4 subunit A;
AltName: Full=Topoisomerase IV subunit A;
Gene name Name=parC;

Comments [?]

FUNCTIONTopoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
CATALYTIC ACTIVITY Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=;
SUBUNITHeterotetramer composed of ParC and ParE.
SUBCELLULAR LOCATIONCell membrane; Peripheral membrane protein.
SIMILARITYBelongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0007059; Biological process:chromosome segregation
GO:0006265; Biological process:DNA topological change
GO:0019897; Cellular component:extrinsic component of plasma membrane

Cross-references [?]

Pfam PF03989; DNA_gyraseA_C; 3-5;
Pfam PF00521; DNA_topoisoIV; 1;
NCBIfam TIGR01061; parC_Gpos; 1;

Features [?]

From: PARC_STRPN (P72525)
Key From To Description Tag Condition FTGroup
ACT_SITE 118 118 /note="O-(5'-phospho-DNA)-tyrosine intermediate" Y
SITE 38 38 /note="Interaction with DNA" K
SITE 74 74 /note="Interaction with DNA" H
SITE 76 76 /note="Interaction with DNA" H
SITE 87 87 /note="Interaction with DNA" R
SITE 93 93 /note="Interaction with DNA" K
SITE 117 117 /note="Transition state stabilizer" R

Additional information [?]

Size range 780-880 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments See MF_00936 for ParC type 1 subfamily.

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