HAMAP logo

HAMAP rule MF_00937

Send feedback

General rule information [?]

Accession MF_00937
Dates 21-JAN-2013 (Created)
1-JUN-2023 (Last updated, Version 13)
Name ParC_type2
Bacteria; Bacillota
Bacteria; Mollicutes
Templates P72525 (PARC_STRPN); P0AFI2 (PARC_ECOLI): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=DNA topoisomerase 4 subunit A;
AltName: Full=Topoisomerase IV subunit A;
Gene name

Comments [?]

Function Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=;
Subunit Heterotetramer composed of ParC and ParE.
Subcellular location Cell membrane; Peripheral membrane protein.
Similarity Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0007059; Biological process: chromosome segregation.
GO:0006265; Biological process: DNA topological change.
GO:0019897; Cellular component: extrinsic component of plasma membrane.

Cross-references [?]

Pfam PF03989; DNA_gyraseA_C; 3-5;
PF00521; DNA_topoisoIV; 1;
NCBIfam TIGR01061; parC_Gpos; 1;

Features [?]

From: PARC_STRPN (P72525)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     118     118       O-(5'-phospho-DNA)-tyrosine intermediate     Y  
SITE (Optional)     38     38       Interaction with DNA     K  
SITE (Optional)     74     74       Interaction with DNA     H  
SITE (Optional)     76     76       Interaction with DNA     H  
SITE (Optional)     87     87       Interaction with DNA     R  
SITE (Optional)     93     93       Interaction with DNA     K  
SITE     117     117       Transition state stabilizer     R  

Additional information [?]

Size range 780-880 amino acids
Related rules None
Fusion None
Comments See MF_00936 for ParC type 1 subfamily.