HAMAP rule MF_00937

General rule information [?]

Accession	MF_00937
Dates	21-JAN-2013 (Created) 1-JUN-2023 (Last updated, Version 13)

Name	ParC_type2

Scope

Bacteria; Bacillota

Bacteria; Mollicutes

Templates

P72525 (PARC_STRPN); P0AFI2 (PARC_ECOLI): [Recover all]

Triggered by

HAMAP; MF_00937 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PARC

Protein name

RecName:		Full=DNA topoisomerase 4 subunit A;
		EC 5.6.2.2;
AltName:		Full=Topoisomerase IV subunit A;

Gene name

parC

Comments [?]

Function	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity	Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2;
Subunit	Heterotetramer composed of ParC and ParE.
Subcellular location	Cell membrane; Peripheral membrane protein.
Similarity	Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.

Keywords [?]

Cell membrane
DNA-binding
Isomerase
Membrane
Topoisomerase

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0007059; Biological process: chromosome segregation.
GO:0006265; Biological process: DNA topological change.
GO:0019897; Cellular component: extrinsic component of plasma membrane.

Cross-references [?]

Pfam	PF03989; DNA_gyraseA_C; 3-5;
	PF00521; DNA_topoisoIV; 1;
NCBIfam	TIGR01061; parC_Gpos; 1;

Features [?]

From: PARC_STRPN (P72525)

Key From To Description Tag Condition FTGroup

ACT_SITE 118 118 O-(5'-phospho-DNA)-tyrosine intermediate Y

SITE (Optional) 38 38 Interaction with DNA K

SITE (Optional) 74 74 Interaction with DNA H

SITE (Optional) 76 76 Interaction with DNA H

SITE (Optional) 87 87 Interaction with DNA R

SITE (Optional) 93 93 Interaction with DNA K

SITE 117 117 Transition state stabilizer R

Additional information [?]

Size range	780-880 amino acids
Related rules	None
Fusion	None
Comments	See MF_00936 for ParC type 1 subfamily.

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