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Annotation rule MF_00943
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General rule information [?]

Accession MF_00943
Dates 13-FEB-2013 (Created)
19-NOV-2019 (Last updated, Version 5)
Name Maleate_isomerase
Templates Q5YXQ1 (MAIA_NOCFA); O24766 (MAIA_ALCFA); Q9WX57 (MAIA_GEOSE); Q88FY4 (MAIA_PSEPK): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Maleate isomerase;
AltName: Full=Maleate cis-trans isomerase;
Gene name

Comments [?]

Function Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate.
Catalytic activity RHEA:13169: maleate = fumarate
Subunit Homodimer.
Miscellaneous Reaction is initiated by nucleophilic attack of cysteine at the double bond, yielding a covalent succinylcysteine-like intermediate.
Similarity Belongs to the maleate isomerase family.

Keywords [?]

Gene Ontology [?]

GO:0050076; Molecular function: maleate isomerase activity.

Cross-references [?]

Pfam PF17645; Amdase; 1;
PIRSF PIRSF015736; MI; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
REGION     76     78       Substrate binding     C-x-V  
REGION     195     196       Substrate binding     V-Q  
ACT_SITE     76     76       Nucleophile     C  
ACT_SITE     194     194       Proton donor     C  
BINDING     14     14       Substrate     N  
BINDING     133     133       Substrate     Y  
BINDING     163     163       Substrate     N  
MOD_RES     76     76       S-(2-succinyl)cysteine     C  

Additional information [?]

Size range 233-282 amino acids
Related rules None
Fusion None