HAMAP rule MF_00943
General rule information
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| Accession |
MF_00943 |
| Dates |
13-FEB-2013 (Created)
14-MAY-2022 (Last updated, Version 7) |
Propagated annotation
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Identifier, protein and gene names
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| Protein name |
|
RecName:
|
Full=Maleate isomerase;
|
|
|
EC 5.2.1.1;
|
|
AltName:
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Full=Maleate cis-trans isomerase;
|
|
| Function |
Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate. |
| Catalytic activity |
RHEA:13169: maleate = fumarate
EC 5.2.1.1
|
| Subunit |
Homodimer. |
| Miscellaneous |
Reaction is initiated by nucleophilic attack of cysteine at the double bond, yielding a covalent succinylcysteine-like intermediate. |
| Similarity |
Belongs to the maleate isomerase family. |
GO:0050076; Molecular function: maleate isomerase activity.
| From: MAIA_NOCFA (Q5YXQ1) |
|
Key
|
|
From
|
|
To
|
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Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
|
BINDING
|
|
76
|
|
78
|
|
/ligand="substrate
|
|
|
|
C-x-V
|
|
|
|
BINDING
|
|
195
|
|
196
|
|
/ligand="substrate
|
|
|
|
V-Q
|
|
|
|
ACT_SITE
|
|
76
|
|
76
|
|
Nucleophile
|
|
|
|
C
|
|
|
|
ACT_SITE
|
|
194
|
|
194
|
|
Proton donor
|
|
|
|
C
|
|
|
|
BINDING
|
|
14
|
|
14
|
|
/ligand="substrate
|
|
|
|
N
|
|
|
|
BINDING
|
|
133
|
|
133
|
|
/ligand="substrate
|
|
|
|
Y
|
|
|
|
BINDING
|
|
163
|
|
163
|
|
/ligand="substrate
|
|
|
|
N
|
|
|
|
MOD_RES
|
|
76
|
|
76
|
|
S-(2-succinyl)cysteine
|
|
|
|
C
|
|
|
Additional information
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| Size range |
233-282 amino acids |
| Related rules |
None |
| Fusion |
None |
