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HAMAP rule MF_00943

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General rule information [?]

Accession MF_00943
Dates 13-FEB-2013 (Created)
14-MAY-2022 (Last updated, Version 7)
Name Maleate_isomerase
Scope(s) Bacteria
Template(s) Q5YXQ1 (MAIA_NOCFA); O24766 (MAIA_ALCFA); Q9WX57 (MAIA_GEOSE); Q88FY4 (MAIA_PSEPK); [ Recover all ]
Triggered by HAMAP; MF_00943 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MAIA
Protein name RecName: Full=Maleate isomerase;
AltName: Full=Maleate cis-trans isomerase;
Gene name Name=maiA;

Comments [?]

FUNCTIONCatalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate.
CATALYTIC ACTIVITY Reaction=maleate = fumarate; Xref=Rhea:RHEA:13169, ChEBI:CHEBI:29806, ChEBI:CHEBI:30780; EC=;
MISCELLANEOUSReaction is initiated by nucleophilic attack of cysteine at the double bond, yielding a covalent succinylcysteine-like intermediate.
SIMILARITYBelongs to the maleate isomerase family.

Keywords [?]

Gene Ontology [?]

GO:0050076; Molecular function:maleate isomerase activity

Cross-references [?]

Pfam PF17645; Amdase; 1;
PIRSF PIRSF015736; MI; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 76 78 /ligand="substrate" C-x-V
BINDING 195 196 /ligand="substrate" V-Q
ACT_SITE 76 76 /note="Nucleophile" C
ACT_SITE 194 194 /note="Proton donor" C
BINDING 14 14 /ligand="substrate" N
BINDING 133 133 /ligand="substrate" Y
BINDING 163 163 /ligand="substrate" N
MOD_RES 76 76 /note="S-(2-succinyl)cysteine" C

Additional information [?]

Size range 233-282 amino acids
Related rules None
Fusion Nter: None Cter: None

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