HAMAP rule MF_00943
General rule information
[?]
| Accession | MF_00943 |
| Dates | 13-FEB-2013 (Created)
14-MAY-2022 (Last updated, Version 7) |
| Name | Maleate_isomerase |
| Scope(s) |
Bacteria |
| Template(s) | Q5YXQ1 (MAIA_NOCFA); O24766 (MAIA_ALCFA); Q9WX57 (MAIA_GEOSE); Q88FY4 (MAIA_PSEPK); [ Recover all ] |
| Triggered by |
HAMAP; MF_00943 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | MAIA |
| Protein name | RecName: Full=Maleate isomerase; EC=5.2.1.1; AltName: Full=Maleate cis-trans isomerase; |
| Gene name | Name=maiA; |
Comments
[?]
| FUNCTION | Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate. |
| CATALYTIC ACTIVITY | Reaction=maleate = fumarate; Xref=Rhea:RHEA:13169, ChEBI:CHEBI:29806, ChEBI:CHEBI:30780; EC=5.2.1.1; |
| SUBUNIT | Homodimer. |
| MISCELLANEOUS | Reaction is initiated by nucleophilic attack of cysteine at the double bond, yielding a covalent succinylcysteine-like intermediate. |
| SIMILARITY | Belongs to the maleate isomerase family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0050076; Molecular function:maleate isomerase activity |
Cross-references
[?]
| Pfam | PF17645; Amdase; 1; |
| PIRSF | PIRSF015736; MI; 1; |
Features
[?]
| From: MAIA_NOCFA (Q5YXQ1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 76 | 78 | /ligand="substrate" | C-x-V | ||||||||
| BINDING | 195 | 196 | /ligand="substrate" | V-Q | ||||||||
| ACT_SITE | 76 | 76 | /note="Nucleophile" | C | ||||||||
| ACT_SITE | 194 | 194 | /note="Proton donor" | C | ||||||||
| BINDING | 14 | 14 | /ligand="substrate" | N | ||||||||
| BINDING | 133 | 133 | /ligand="substrate" | Y | ||||||||
| BINDING | 163 | 163 | /ligand="substrate" | N | ||||||||
| MOD_RES | 76 | 76 | /note="S-(2-succinyl)cysteine" | C | ||||||||
Additional information
[?]
| Size range | 233-282 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |