HAMAP rule MF_00946
General rule information
[?]
| Accession | MF_00946 |
| Dates | 4-MAR-2013 (Created)
26-JAN-2023 (Last updated, Version 6) |
| Name | HdeA |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P0AES9 (HDEA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00946 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | HDEA |
| case <OC:Enterobacterales> | |
| Protein name | RecName: Full=Acid stress chaperone HdeA; |
| else | |
| Protein name | RecName: Full=Probable acid stress chaperone HdeA; |
| end case | |
| Gene name | Name=hdeA; |
Comments
[?]
| FUNCTION | Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins. |
| SUBCELLULAR LOCATION | Periplasm. |
| SIMILARITY | Belongs to the HdeA family. |
Keywords
[?]
| Chaperone | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
| Periplasm | |
Gene Ontology
[?]
| GO:1990451; Biological process:cellular stress response to acidic pH |
| GO:0042597; Cellular component:periplasmic space |
Cross-references
[?]
| Pfam | PF06411; HdeA; 1; |
| PIRSF | PIRSF009564; HNS-dep_expression_A; 1; |
| General | Signal; -; 1; |
Features
[?]
| From: HDEA_ECOLI (P0AES9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DISULFID | 39 | 87 | disulf | C-x*-C | ||||||||
Additional information
[?]
| Size range | 93-127 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |