HAMAP rule MF_00961

General rule information [?]

Accession	MF_00961
Dates	22-MAY-2013 (Created) 1-JUN-2023 (Last updated, Version 11)

Name	Sigma70_RpoH

Scope

Bacteria; Pseudomonadota

Template

P0AGB3 (RPOH_ECOLI)

Triggered by

HAMAP; MF_00961 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

RPOH

Protein name

RecName:		Full=RNA polymerase sigma factor RpoH;
AltName:		Full=RNA polymerase sigma-32 factor;

Gene name

rpoH

Comments [?]

Function	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.
Subunit	Interacts with the RNA polymerase core enzyme.
Subcellular location	Cytoplasm.
Similarity	Belongs to the sigma-70 factor family. RpoH subfamily.

Keywords [?]

Cytoplasm
DNA-binding
Sigma factor
Stress response
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0016987; Molecular function: sigma factor activity.
GO:0010468; Biological process: regulation of gene expression.
GO:0009408; Biological process: response to heat.
GO:0006352; Biological process: DNA-templated transcription initiation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE	PS00715; SIGMA70_1; 1;
	PS00716; SIGMA70_2; 1;
Pfam	PF00140; Sigma70_r1_2; 0-1;
	PF04542; Sigma70_r2; 1;
	PF04545; Sigma70_r4; 1;
PRINTS	PR00046; SIGMA70FCT; 1;
NCBIfam	TIGR02392; rpoH_proteo; 1;
	TIGR02937; sigma70-ECF; 1;

Features [?]

From: RPOH_ECOLI (P0AGB3)

Key From To Description Tag Condition FTGroup

DNA_BIND 253 272 H-T-H motif

REGION 53 122 Sigma-70 factor domain-2

REGION 228 280 Sigma-70 factor domain-4

MOTIF 77 80 Interaction with polymerase core subunit RpoC [DE]-[LVIM]-[IVM]-[QSA]

Additional information [?]

Size range	250-406 amino acids
Related rules	None
Fusion	None

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