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HAMAP rule MF_00961

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General rule information [?]

Accession MF_00961
Dates 22-MAY-2013 (Created)
1-JUN-2023 (Last updated, Version 11)
Name Sigma70_RpoH
Scope(s) Bacteria
Template(s) P0AGB3 (RPOH_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00961 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RPOH
Protein name RecName: Full=RNA polymerase sigma factor RpoH;
AltName: Full=RNA polymerase sigma-32 factor;
Gene name Name=rpoH;

Comments [?]

FUNCTIONSigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.
SUBUNITInteracts with the RNA polymerase core enzyme.
SIMILARITYBelongs to the sigma-70 factor family. RpoH subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0016987; Molecular function:sigma factor activity
GO:0010468; Biological process:regulation of gene expression
GO:0009408; Biological process:response to heat
GO:0006352; Biological process:DNA-templated transcription initiation
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS00715; SIGMA70_1; 1;
PROSITE PS00716; SIGMA70_2; 1;
Pfam PF00140; Sigma70_r1_2; 0-1;
Pfam PF04542; Sigma70_r2; 1;
Pfam PF04545; Sigma70_r4; 1;
NCBIfam TIGR02392; rpoH_proteo; 1;
NCBIfam TIGR02937; sigma70-ECF; 1;

Features [?]

Key From To Description Tag Condition FTGroup
DNA_BIND 253 272 /note="H-T-H motif"
REGION 53 122 /note="Sigma-70 factor domain-2"
REGION 228 280 /note="Sigma-70 factor domain-4"
MOTIF 77 80 /note="Interaction with polymerase core subunit RpoC" [DE]-[LVIM]-[IVM]-[QSA]

Additional information [?]

Size range 250-406 amino acids
Related rules None
Fusion Nter: None Cter: None

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