HAMAP rule MF_00962

General rule information [?]

Accession	MF_00962
Dates	27-MAY-2013 (Created) 1-JUN-2023 (Last updated, Version 10)

Name	Sigma70_FliA

Scope

Bacteria; Pseudomonadota

Template

P0AEM6 (FLIA_ECOLI)

Triggered by

HAMAP; MF_00962 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

FLIA

Protein name

RecName:		Full=RNA polymerase sigma factor FliA;
AltName:		Full=RNA polymerase sigma factor for flagellar operon;
AltName:		Full=Sigma F;
AltName:		Full=Sigma-28;

Gene name

fliA

Comments [?]

Function	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.
Subcellular location	Cytoplasm.
Similarity	Belongs to the sigma-70 factor family. FliA subfamily.

Keywords [?]

Cytoplasm
DNA-binding
Sigma factor
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0016987; Molecular function: sigma factor activity.
GO:0010468; Biological process: regulation of gene expression.
GO:0006352; Biological process: DNA-templated transcription initiation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE	PS00715; SIGMA70_1; 1;
	PS00716; SIGMA70_2; 1;
Pfam	PF04542; Sigma70_r2; 1;
	PF04539; Sigma70_r3; 1;
	PF04545; Sigma70_r4; 1;
PRINTS	PR00046; SIGMA70FCT; 1;
NCBIfam	TIGR02479; FliA_WhiG; 1;
	TIGR02937; sigma70-ECF; 1;

Features [?]

From: FLIA_ECOLI (P0AEM6)

Key From To Description Tag Condition FTGroup

DNA_BIND 207 226 H-T-H motif

REGION 16 88 Sigma-70 factor domain-2

REGION 96 166 Sigma-70 factor domain-3

REGION 185 233 Sigma-70 factor domain-4

MOTIF 43 46 Interaction with polymerase core subunit RpoC D-[LMI]-[LIVMT]-Q

Additional information [?]

Size range	207-306 amino acids
Related rules	None
Fusion	None

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