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HAMAP rule MF_00974

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General rule information [?]

Accession MF_00974
Dates 16-OCT-2013 (Created)
1-JUN-2023 (Last updated, Version 7)
Name DNA_primase_DnaG
Templates P0ABS5 (DNAG_ECOLI); O67465 (DNAG_AQUAE); Q9X4D0 (DNAG_GEOSE): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=DNA primase;
Gene name

Comments [?]

Function RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Catalytic activity Reaction=ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.; EC=;
Subunit Monomer. Interacts with DnaB.
case <FTTag:zinc>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per monomer.
Domain Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
end case
Similarity Belongs to the DnaG primase family.

Keywords [?]

case <FTTag:zinc>
end case

Gene Ontology [?]

GO:0003896; Molecular function: DNA primase activity.
case <FTTag:zinc>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0006269; Biological process: DNA replication, synthesis of RNA primer.

Cross-references [?]

PROSITE PS50880; TOPRIM; 1; trigger=PRU00995;
Pfam PF10410; DnaB_bind; 1;
PF08278; DnaG_DnaB_bind; 1;
PF13662; Toprim_4; 1;
PF08275; Toprim_N; 1;
PF01807; zf-CHC2; 1;
PF01751; Toprim; 1;
NCBIfam TIGR01391; dnaG; 1;
PIRSF PIRSF002811; DnaG; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     40     64       CHC2-type   zinc   C-x(2)-H-x(17,18)-C-x(2,3)-C  

Additional information [?]

Size range 410-800 amino acids
Related rules None
Fusion None