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HAMAP rule MF_00974

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General rule information [?]

Accession MF_00974
Dates 16-OCT-2013 (Created)
1-JUN-2023 (Last updated, Version 7)
Name DNA_primase_DnaG
Scope(s) Bacteria
Template(s) P0ABS5 (DNAG_ECOLI); O67465 (DNAG_AQUAE); Q9X4D0 (DNAG_GEOSE); [ Recover all ]
Triggered by HAMAP; MF_00974 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DNAG
Protein name RecName: Full=DNA primase;
Gene name Name=dnaG;

Comments [?]

FUNCTIONRNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
CATALYTIC ACTIVITY Reaction=ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.; EC=;
SUBUNITMonomer. Interacts with DnaB.
case <FTTag:zinc>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per monomer.;
DOMAINContains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB- binding domain.
end case
SIMILARITYBelongs to the DnaG primase family.

Keywords [?]

Gene Ontology [?]

GO:0003896; Molecular function:DNA primase activity
case <FTTag:zinc>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0006269; Biological process:DNA replication, synthesis of RNA primer

Cross-references [?]

Pfam PF10410; DnaB_bind; 1;
Pfam PF08278; DnaG_DnaB_bind; 1;
Pfam PF13662; Toprim_4; 1;
Pfam PF08275; Toprim_N; 1;
Pfam PF01807; zf-CHC2; 1;
Pfam PF01751; Toprim; 1;
NCBIfam TIGR01391; dnaG; 1;
PIRSF PIRSF002811; DnaG; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ZN_FING 40 64 /note="CHC2-type" zinc C-x(2)-H-x(17,18)-C-x(2,3)-C

Additional information [?]

Size range 410-800 amino acids
Related rules None
Fusion Nter: None Cter: None

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