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HAMAP rule MF_00975

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General rule information [?]

Accession MF_00975
Dates 24-OCT-2013 (Created)
19-NOV-2022 (Last updated, Version 5)
Name Exosome_Csl4
Templates Q980J9 (CSL4_SACS2); O30033 (CSL4_ARCFU): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Exosome complex component Csl4;
Gene name

Comments [?]

Function Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
Subunit Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
Subcellular location Cytoplasm.
Similarity Belongs to the CSL4 family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS50126; S1; 1; trigger=PRU00180;
Pfam PF14382; ECR1_N; 1;
PF00575; S1; 1;
PF10447; EXOSC1; 1;

Features [?]

From: CSL4_ARCFU (O30033)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     143     143       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     146     146       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     159     159       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     162     162       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1

Additional information [?]

Size range 176-362 amino acids
Related rules None
Fusion None