HAMAP rule MF_00985

General rule information [?]

Accession	MF_00985
Dates	17-JAN-2014 (Created) 1-JUN-2023 (Last updated, Version 10)

Name	2am3keto_CoA_ligase

Scope

Bacteria

Template

P0AB77 (KBL_ECOLI)

Triggered by

HAMAP; MF_00985 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

KBL

Protein name

RecName:		Full=2-amino-3-ketobutyrate coenzyme A ligase;
		Short=AKB ligase;
		EC 2.3.1.29;
AltName:		Full=Glycine acetyltransferase;

Gene name

kbl

Comments [?]

Function	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
Catalytic activity	RHEA:20736: acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA EC 2.3.1.29
Cofactor	pyridoxal 5'-phosphate Note: Binds 1 pyridoxal phosphate per subunit.
Pathway	Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.
Subunit	Homodimer.
Similarity	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Keywords [?]

Acyltransferase
Pyridoxal phosphate
Transferase

Gene Ontology [?]

GO:0008890; Molecular function: glycine C-acetyltransferase activity.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0019518; Biological process: L-threonine catabolic process to glycine.

Cross-references [?]

PROSITE	PS00599; AA_TRANSFER_CLASS_2; 1;
Pfam	PF00155; Aminotran_1_2; 1;
NCBIfam	TIGR01822; 2am3keto_CoA; 1;

Features [?]

From: KBL_ECOLI (P0AB77)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 111 112 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" /ligand_note="ligand shared between dimeric partners" /note="in other chain C-[FY]

BINDING (Optional) 210 213 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" /ligand_note="ligand shared between dimeric partners" /note="in other chain [DE]-[DE]-S-H

BINDING (Optional) 241 244 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" /ligand_note="ligand shared between dimeric partners" /note="in other chain T-[LF]-G-K

BINDING (Optional) 274 275 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" /ligand_note="ligand shared between dimeric partners S-N

BINDING (Optional) 136 136 /ligand="substrate H

BINDING (Optional) 185 185 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" /ligand_note="ligand shared between dimeric partners" /note="in other chain S

BINDING (Optional) 368 368 /ligand="substrate R

MOD_RES 244 244 N6-(pyridoxal phosphate)lysine K

Additional information [?]

Size range	378-460 amino acids
Related rules	None
Fusion	None

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