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HAMAP rule MF_00985

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General rule information [?]

Accession MF_00985
Dates 17-JAN-2014 (Created)
1-JUN-2023 (Last updated, Version 10)
Name 2am3keto_CoA_ligase
Template P0AB77 (KBL_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=2-amino-3-ketobutyrate coenzyme A ligase;
Short=AKB ligase;
AltName: Full=Glycine acetyltransferase;
Gene name

Comments [?]

Function Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
Catalytic activity RHEA:20736: acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA
Cofactor pyridoxal 5'-phosphate
Note: Binds 1 pyridoxal phosphate per subunit.
Pathway Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.
Subunit Homodimer.
Similarity Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Keywords [?]

Gene Ontology [?]

GO:0008890; Molecular function: glycine C-acetyltransferase activity.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0019518; Biological process: L-threonine catabolic process to glycine.

Cross-references [?]

Pfam PF00155; Aminotran_1_2; 1;
NCBIfam TIGR01822; 2am3keto_CoA; 1;

Features [?]

From: KBL_ECOLI (P0AB77)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     111     112       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" /ligand_note="ligand shared between dimeric partners" /note="in other chain     C-[FY]  
BINDING (Optional)     210     213       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" /ligand_note="ligand shared between dimeric partners" /note="in other chain     [DE]-[DE]-S-H  
BINDING (Optional)     241     244       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" /ligand_note="ligand shared between dimeric partners" /note="in other chain     T-[LF]-G-K  
BINDING (Optional)     274     275       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" /ligand_note="ligand shared between dimeric partners     S-N  
BINDING (Optional)     136     136       /ligand="substrate     H  
BINDING (Optional)     185     185       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" /ligand_note="ligand shared between dimeric partners" /note="in other chain     S  
BINDING (Optional)     368     368       /ligand="substrate     R  
MOD_RES     244     244       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 378-460 amino acids
Related rules None
Fusion None